Results 241 to 250 of about 328,516 (352)

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

Advanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu   +13 more
wiley   +1 more source

Recombinant Expression of a Ready-to-Use EGF Variant Equipped With a Single Conjugation Site for Click-Chemistry. [PDF]

Eng Life Sci
Krass M, Kolster M, Valenzuela JI, Moldenhauer L, Kagelmacher M, Niesler N, Weng A, Zerial M, Nagel G, Fuchs H.   +9 more
europepmc   +1 more source

Surface functionalization of nanofibrillated cellulose using click-chemistry approach in aqueous media [PDF]

, 2011
Nikolaos Pahimanolis, Ulla Hippi, Leena‐Sisko Johansson, Tapio Saarinen, Nikolay Houbenov, Janne Ruokolainen, Jukka Seppälä   +6 more
openalex   +1 more source

The Molecular Basis of Amino Acids Sensing

Advanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang, Xiao Tan, Jiali Jin, Ping Wang   +3 more
wiley   +1 more source

Design and Biosynthesis of Ornithine 8-Containing Semaglutide Variants with a Click Chemistry-Modifiable Position 26. [PDF]

ACS Synth Biol
Xu Y, Kuipers OP.
europepmc   +1 more source

Photochemical Ligation of DNA Probe prepared in Click Chemistry

, 2009
Yoshinaga Yoshimura, T Matsuzaki, Kenzo Fujimoto   +2 more
openalex   +2 more sources

Copper‐Catalyzed Azide–Alkyne Click Chemistry for Bioconjugation [PDF]

, 2011
Stanislav I. Presolski, Vu Hong, M. G. Finn   +2 more
openalex   +1 more source

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Advanced Science, EarlyView.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming‐an Sun, Yanhua Li   +13 more
wiley   +1 more source

Gemcitabine-Doxorubicin Combination Polymer-Drug Conjugate Prepared by SPAAC Click Chemistry: In Vitro Characterization. [PDF]

Int J Mol Sci
Gbadegesin OD, Adesina SK.
europepmc   +1 more source

Genetically Encoded Copper‐Free Click Chemistry [PDF]

, 2011
Tilman Plass, Sigrid Milles, Christine Koehler, Carsten Schultz, Edward A. Lemke   +4 more
openalex   +1 more source