Results 41 to 50 of about 327,716 (251)
Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry
Molecules, 2023 Alkaloids found in multiple species, known as ‘driver species’, are more likely to be included in early-stage drug development due to their high biodiversity compared to rare alkaloids.
Devan Buchanan +3 more
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Machine learning-guided computational screening of new bio-orthogonal click reactions [PDF]
arXiv, 2022 Bio-orthogonal click chemistry has become an indispensable part of the biochemist's toolbox. Despite the wide variety of applications that have been developed in recent years, only a limited number of bio-orthogonal click reactions have been discovered so far, most of them based on (substituted) azides. In this work, we present a computational workflow
arxiv
Click Chemistry in Proteomic Investigations [PDF]
Cell, 2020 Despite advances in genetic and proteomic techniques, a complete portrait of the proteome and its complement of dynamic interactions and modifications remains a lofty, and as of yet, unrealized, objective. Specifically, traditional biological and analytical approaches have not been able to address key questions relating to the interactions of proteins ...
Christopher G. Parker, Matthew R. Pratt
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Click chemistry and drug delivery: A bird's-eye view
Acta Pharmaceutica Sinica B, 2023 Click chemistry has been proven to be very useful in drug delivery. Due to the availability of a large number of click reactions with a various characteristics, selection of appropriate chemistry for a given application is often not a trivial task.
Shameer M. Kondengadan +5 more
doaj
Click Chemistry in Peptide-Based Drug Design
Molecules, 2013 Click chemistry is an efficient and chemoselective synthetic method for coupling molecular fragments under mild reaction conditions. Since the advent in 2001 of methods to improve stereochemical conservation, the click chemistry approach has been broadly
Irwin Chaiken, Rachna Aneja, Huiyuan Li
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Development, Processing and Applications of a UV-Curable Polymer with Surface Active Thiol Groups [PDF]
Nanomaterials 2020, 10(9), 1829, 2020 We present here a novel resist formulation with active thiol groups at the surface. The material is UV curable, and can be patterned at the micro- and nanoscale by UV nanoimprint lithography. The resist formulation development, its processing, patterning and surface characterization are presented here. In addition, a possible application, including its
arxiv +1 more source
Organotitanium Click Chemistry
Fine Chemical Engineering, 2023 The click chemistry of titanium exemplified by the “green” [3+2] cycloaddition of the [Ti-N3] moiety with nitriles RCN to form a tetrazole ligand, is currently limited in scope, but the future of this open and wide field is bright, full of promising new synthetic approaches discussed herein, for pharmacological and bio orthogonal applications.
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ChemInform Abstract: Polysaccharides: The “Click” Chemistry Impact [PDF]
ChemInform, 2011 AbstractReview: 82 refs.
Elchinger, Pierre-Henri +6 more
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Click to learn, learn to click: undergraduate synthetic organic chemistry experiments [PDF]
, 2023 The optimization of an undergraduate experiment for Organic Chemistry students is described to explore the concept of click chemistry. The preparation of a terminal fluorescent alkyne and an organic azide is reported consisting of simple steps.
Lopez-Ruiz, Alejandro +3 more
core +1 more source
Current Research in Green and Sustainable Chemistry, 2021 WHO holding the hands of the scientific commune and trying to repurpose the drugs against the SARS-CoV-2. The robust scientific data has illustrated the probable mechanistic path of SARS-CoV-2 entry and action in damaging the cells.
Satyaki Chatterjee +4 more
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