Results 31 to 40 of about 354,979 (259)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Large near-term projected snowpack loss over the western United States

Nature Communications, 2017
Mountain snowpack in the western United States has declined over the past three decades. Fyfeet al. show that this trend cannot be explained by natural variability alone and show that under a business-as-usual scenario a further loss of up to 60% in ...
John C. Fyfe, Chris Derksen, Lawrence Mudryk, Gregory M. Flato, Benjamin D. Santer, Neil C. Swart, Noah P. Molotch, Xuebin Zhang, Hui Wan, Vivek K. Arora, John Scinocca, Yanjun Jiao   +11 more
doaj   +1 more source

Early Development and Tuning of a Global Coupled Cloud Resolving Model, and its Fast Response to Increasing CO2

Tellus: Series A, Dynamic Meteorology and Oceanography, 2022
Since the dawn of functioning numerical dynamical atmosphere- and ocean models, their resolution has steadily increased, fed by an exponential growth in computational capabilities.
Thorsten Mauritsen, Rene Redler, Monika Esch, Bjorn Stevens, Cathy Hohenegger, Daniel Klocke, Renate Brokopf, Helmuth Haak, Leonidas Linardakis, Niklas Röber, Reiner Schnur   +10 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A Diagnostic PDF Cloud Scheme to Improve Subtropical Low Clouds in NCAR Community Atmosphere Model (CAM5)

Journal of Advances in Modeling Earth Systems, 2018
Low clouds strongly impact the radiation budget of the climate system, but their simulation in most GCMs has remained a challenge, especially over the subtropical stratocumulus region.
Yi Qin, Yanluan Lin, Shiming Xu, Hsi‐Yen Ma, Shaocheng Xie   +4 more
doaj   +1 more source

Cloud Computing for Climate Modelling: Evaluation, Challenges and Benefits

Computers, 2020
Cloud computing is a mature technology that has already shown benefits for a wide range of academic research domains that, in turn, utilize a wide range of application design models.
Diego Montes , Juan A. Añel , David C. H. Wallom , Peter Uhe , Pablo V. Caderno, Tomás F. Pena   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Desertification Mitigation in Northern China Was Promoted by Climate Drivers after 2000

Remote Sensing
Desertification greatly threatens the ecological environment and sustainable development over approximately 30% of global land. In this study, the contributions of climate drivers and human activity in shaping the desertification process from 1984 to ...
Haohui Li, Kai Yang, Yang Cui, Lingyun Ai, Chenghai Wang, Zhenting Wang, Caixia Zhang   +6 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source