Results 11 to 20 of about 901,815 (336)

The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection

Frontiers in Immunology, 2020
The RTS,S/AS01 vaccine provides partial protection against Plasmodium falciparum infection but determinants of protection and/or disease are unclear. Previously, anti-circumsporozoite protein (CSP) antibody titers and blood RNA signatures were associated
Ying Du, Ethan G. Thompson, Julius Muller, Joseph Valvo, Jackie Braun, Smitha Shankar, Robert A. van den Berg, Erik Jongert, Drew Dover, Jerald Sadoff, Jenny Hendriks, Malcolm J. Gardner, W. Ripley Ballou, Jason A. Regules, Robbert van der Most, Alan Aderem, Christian F. Ockenhouse, Adrian V. Hill, Ulrike Wille-Reece, Daniel E. Zak   +19 more
doaj   +1 more source

Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis

Frontiers in Immunology, 2022
Highly heterogeneous cell populations require multiple flow cytometric markers for appropriate phenotypic characterization. This exponentially increases the complexity of 2D scatter plot analyses and exacerbates human errors due to variations in manual ...
Anthony S. Bonavia, Anthony S. Bonavia, Abigail Samuelsen, Joshua Luthy, E. Scott Halstead   +4 more
doaj   +1 more source

Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen‐specific T cell responses in allergic sensitized children

Clinical and Translational Allergy, 2021
Background Characterization of allergic responses to cockroach (CR), a common aeroallergen associated with asthma, has focused mainly on IgE reactivity, but little is known about T cell responses, particularly in children.
Ricardo daSilva Antunes, Aaron Sutherland, April Frazier, Veronique Schulten, Anna Pomés, Jill Glesner, Agustin Calatroni, Matthew C. Altman, Robert A. Wood, George T. O'Connor, Jacqueline A. Pongracic, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Rebecca S. Gruchalla, Michelle Gill, Andrew H. Liu, Edward Zoratti, Meyer Kattan, Paula J. Busse, Leonard B. Bacharier, Stephen J. Teach, Lisa M. Wheatley, Alkis Togias, William W. Busse, Daniel J. Jackson, Alessandro Sette   +25 more
doaj   +1 more source

The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation : a case series [PDF]

, 2021
BACKGROUND: The impact of HLA-DP mismatches on renal allograft outcome is still poorly understood and is suggested to be less than that of the other HLA loci.
Abramowicz, D, Claas, FHJ, Daniëls, L, Edmonds, MP, Hellemans, R, Kramer, CSM, Naessens, M, Senev, A, Van Laecke, Steven, Vanden Driessche, M   +9 more
core   +2 more sources

Ocular Motor Abnormalities in Anti-IgLON5 Disease

Frontiers in Immunology, 2021
ObjectiveAnti-IgLON5 disease forms an interface between neuroinflammation and neurodegeneration and includes clinical phenotypes that are often similar to those of neurodegenerative diseases.
Stefan Macher, Ivan Milenkovic, Tobias Zrzavy, Romana Höftberger, Stefan Seidel, Evelyn Berger-Sieczkowski, Thomas Berger, Paulus S. Rommer, Gerald Wiest   +8 more
doaj   +1 more source

Evaluation of Subjects Experiencing Allergic Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Characteristics and Drugs Involved

Frontiers in Pharmacology, 2020
Non-steroidal anti-inflammatory drugs (NSAIDs), the most commonly prescribed and consumed medicines worldwide, are the main triggers of drug hypersensitivity reactions (DHRs).
Natalia Pérez-Sánchez, Natalia Pérez-Sánchez, Inmaculada Doña, Gador Bogas, María Salas, Almudena Testera, José A. Cornejo-García, María J. Torres, María J. Torres, María J. Torres, María J. Torres   +10 more
doaj   +1 more source

TMBserval: a statistical explainable learning model reveals weighted tumor mutation burden better categorizing therapeutic benefits

Frontiers in Immunology, 2023
A high tumor mutation burden (TMB) is known to drive the response to immune checkpoint inhibitors (ICI) and is associated with favorable prognoses. However, because it is a one-dimensional numerical representation of non-synonymous genetic alterations ...
Yixuan Wang, Jiayin Wang, Wenfeng Fang, Xiao Xiao, Quan Wang, Jian Zhao, Jingjing Liu, Shuanying Yang, Yuqian Liu, Xin Lai, Xiaofeng Song   +10 more
doaj   +1 more source

Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]

, 2010
The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Koido, Shigeo, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao   +6 more
core   +11 more sources

ImmPort, toward repurposing of open access immunological assay data for translational and clinical research [PDF]

, 2018
Immunology researchers are beginning to explore the possibilities of reproducibility, reuse and secondary analyses of immunology data. Open-access datasets are being applied in the validation of the methods used in the original studies, leveraging ...
Bhattacharya, Sanchita, Butte, Atul, Chen, Jieming, Dunn, Patrick, Hu, Zicheng, Schaefer, Henry, Shankar, Ravi, Shen-Orr, Shai, Smith, Barry, Thomas, Cristel, Thomson, Elizabeth, Wiser, Jeffrey, Zalocusky, Kelly   +12 more
core   +2 more sources

Dermatology [PDF]

, 2004
Dermatology continues to develop at a steady pace. In the past few years there have been exciting advances in our understanding of skin structure and function in health and disease and progress in genetics, epidemiology, immunology, pharmacology and ...
Boffa, Michael J.
core   +1 more source