Results 61 to 70 of about 901,815 (336)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Current situation of allergy education in Mexico and other parts of Latin America

World Allergy Organization Journal, 2021
Allergic diseases are one of the most frequent chronic diseases in the world. It has been established that there is a worldwide epidemic of allergic diseases; therefore, the treatment of allergies should be acknowledged as a worldwide priority and the ...
Sandra Nora Gonzalez-Diaz, Bryan Martin, Cindy Elizabeth de Lira-Quezada, Rosalaura Virginia Villarreal-Gonzalez, Rosa Ivett Guzman-Avilan, Alejandra Macías-Weinmann, José Antonio Ortega-Martell, Carlos Macouzet-Sanchez, Mario Sánchez-Borges, Nelson Augusto Rosario Filho, Anahí Yañez, María Antonieta Guzman-Melendez, Ricardo Cardona, Olga Patricia Monge-Ortega, Ivan Cherrez-Ojeda, Dayanara Herrera-Castro, Marylin Valentin-Rostan, Juan Carlos Sisul-Alvariza, Ignacio J. Ansotegui, Barbara Elizondo-Villarreal   +19 more
doaj   +1 more source

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Low-Density Granulocytes Are a Novel Immunopathological Feature in Both Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder [PDF]

, 2019
Objective: To investigate whether low-density granulocytes (LDGs) are an immunophenotypic feature of patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD).
Alexander, Tobias, Asseyer, Susanna, Bellmann-Strobl, Judith, Hauser, Anja E., Koppen, Sofie van, Lindquist, Randall L., Mothes, Ronja, Niesner, Raluca A., Ostendorf, Lennard, Paul, Friedemann, Radbruch, Helena, Ruprecht, Klemens   +11 more
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

WAO guideline for the management of hereditary angioedema [PDF]

, 2012
Hereditary Angioedema (HAE) is a rare disease and for this reason proper diagnosis and appropriate therapy are often unknown or not available for physicians and other health care providers.
Aygören-Pürsün, Emel, Bork, Konrad, Bowen, Tom, Boysen, Henrik B., Craig, Timothy, Farkas, Henriette, Grumach, Anete, Katelaris, Constance H., Lockey, Richard, Longhurst, Hilary, Lumry, William, Magerl, Markus, Martinez-Saguer, Immaculada, Maurer, Marcus, Nast, Alexander, Pawankar, Ruby, Ritchie, Bruce, Zuraw, Bruce   +17 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Concentrations of Cysteinyl Leukotrienes in Various Biological Fluids of Children with Bronchial Asthma, Atopic Dermatitis and Food Protein Induced Enterocolitis [PDF]

, 2019
Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma ...
Haiduchyk, H. (Halyna), Shadrin, O. (Oleg)   +1 more
core   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source