Results 1 to 10 of about 1,857,753 (293)

Considerations on the Obstacles That Lead to Slow Recruitment in a Pain Management Clinical Trial: Experiences from the Belgian PELICAN (PrEgabalin Lidocaine Capsaicin Neuropathic Pain) Pragmatic Study

Pain Research and Management, 2023
Background. A qualitative evaluation study of the prematurely terminated PrEgabalin Lidocaine Capsaicin Neuropathic Pain (PELICAN) study was performed.
Guy H. Hans, Dima Almeshal, Lotte Vanlommel, Ella Roelant, Iris Verhaegen, Elke Smits, Koen Van Boxem, Robert Fontaine, The PELICAN Investigators Team   +8 more
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Development and Validation of a Prediction Model for Venous Thrombus Embolism (VTE) in Patients With Colorectal Cancer

Technology in Cancer Research & Treatment, 2023
Cancer patients are at high risk of developing venous thromboembolism (VTE). The risk of VTE could be mitigated with the administration of prophylactic anticoagulants.
Wei-Juan Tan MS, Lu Chen MS, Sheng-Jie Yang MD, Bao-Ying Zhang MD, Ming-Li Sun MD, Yu-Bin Lin MS, Xing-He Wang MD, PhD   +6 more
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Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

Pharmacology Research & Perspectives, 2023
HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese ...
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu   +9 more
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Differential impact of osteoporosis, sarcopenia and obesity on physical performance in aging men

Endocrine Connections, 2021
Purpose: Aging and concurrent constitutional changes as sarcopenia, osteoporosis and obesity are associated with progressive functional decline. Coincidence and mutual interference of this risk factors require further evaluation.
Franca Genest, Michael Schneider, Andreas Zehnder, Dominik Lieberoth-Leden, Lothar Seefried   +4 more
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Co-expression and prognosis analyses of GLUT1–4 and RB1 in breast cancer

BMC Cancer, 2021
Background Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor.
Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang, Yimin Cui   +6 more
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Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201

CPT: Pharmacometrics & Systems Pharmacology, 2023
PB‐201 is the second glucokinase activator in the world to enter the phase III clinical trials for the treatment of type 2 diabetes mellitus (T2DM).
Miao Zhang, Zihan Lei, Ziheng Yu, Xueting Yao, Haiyan Li, Min Xu, Dongyang Liu   +6 more
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The prevention and treatment of COVID-19 in patients treated with hemodialysis

European Journal of Medical Research, 2023
Patients treated with hemodialysis are often immunocompromised due to concomitant disease. As a result, this population is at high risk of infection and mortality from COVID-19.
Binyu Zeng, Jia Zhou, Daizhuang Peng, Chengmei Dong, Qun Qin   +4 more
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Novel indicator for the spread of new coronavirus disease 2019 and its association with human mobility in Japan

Scientific Reports, 2023
The Japanese government adopted policies to control human mobility in 2020 to prevent the spread of severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). The present study examined the impact of human mobility
Yuta Kawakami, Shuko Nojiri, Daisuke Nakamoto, Yoshiki Irie, Satoshi Miyazawa, Manabu Kuroki, Yuji Nishizaki   +6 more
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A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial

Trials, 2020
Objectives Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Secondary objectives: To evaluate the efficacy
Irene García García, Miguel Rodriguez-Rubio, Amelia Rodríguez Mariblanca, Lucía Martínez de Soto, Lucía Díaz García, Jaime Monserrat Villatoro, Javier Queiruga Parada, Enrique Seco Meseguer, María J. Rosales, Juan González, José R. Arribas, Antonio J. Carcas, Pedro de la Oliva, Alberto M. Borobia   +13 more
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Safety and Tolerability of an Antimalarial Herbal Remedy in Healthy Volunteers: An Open-Label, Single-Arm, Dose-Escalation Study on Maytenus senegalensis in Tanzania

Tropical Medicine and Infectious Disease, 2022
Background: Though Maytenus senegalensis is one of the medicinal plants widely used in traditional medicine to treat infectious and inflammatory diseases in Africa, there is a lack of safety data regarding its use.
Kamaka Kassimu, Florence Milando, Justin Omolo, Abel Mdemu, Gloria Nyaulingo, Hussein Mbarak, Latipha Mohamed, Ramla Rashid, Saumu Ahmed, Mohammed Rashid, Hania Msami, David Damiano, Beatus Simon, Thabit Mbaga, Fatuma Issa, Omar Lweno, Neema Balige, Omary Hassan, Bakari Mwalimu, Ali Hamad, Ally Olotu, Andreas Mårtensson, Francis Machumi, Said Jongo, Billy Ngasala, Salim Abdulla   +25 more
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