Results 1 to 10 of about 13,113,839 (405)

Considerations on the Obstacles That Lead to Slow Recruitment in a Pain Management Clinical Trial: Experiences from the Belgian PELICAN (PrEgabalin Lidocaine Capsaicin Neuropathic Pain) Pragmatic Study

Pain Research and Management, 2023
Background. A qualitative evaluation study of the prematurely terminated PrEgabalin Lidocaine Capsaicin Neuropathic Pain (PELICAN) study was performed.
Guy H. Hans, Dima Almeshal, Lotte Vanlommel, Ella Roelant, Iris Verhaegen, Elke Smits, Koen Van Boxem, Robert Fontaine, The PELICAN Investigators Team   +8 more
doaj   +1 more source

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

Science, 2021
Description Antibody levels predict vaccine efficacy Symptomatic COVID-19 infection can be prevented by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.
P. Gilbert, D. Montefiori, A. McDermott, Y. Fong, D. Benkeser, Wei-zhi Deng, Honghong Zhou, Christopher R. Houchens, Karen Martins, L. Jayashankar, F. Castellino, B. Flach, Bob C. Lin, S. O'connell, C. McDanal, Amanda Eaton, M. Sarzotti-Kelsoe, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars van der Laan, N. Hejazi, C. Huynh, Jacqueline Miller, Hana M. El Sahly, L. Baden, Mira Baron, Luis de la Cruz, C. Gay, Spyros A. Kalams, Colleen F. Kelley, M. Andrasik, J. Kublin, L. Corey, K. Neuzil, Lindsay N. Carpp, R. Pajon, D. Follmann, R. Donis, R. Koup   +39 more
semanticscholar   +1 more source

Development and Validation of a Prediction Model for Venous Thrombus Embolism (VTE) in Patients With Colorectal Cancer

Technology in Cancer Research & Treatment, 2023
Cancer patients are at high risk of developing venous thromboembolism (VTE). The risk of VTE could be mitigated with the administration of prophylactic anticoagulants.
Wei-Juan Tan MS, Lu Chen MS, Sheng-Jie Yang MD, Bao-Ying Zhang MD, Ming-Li Sun MD, Yu-Bin Lin MS, Xing-He Wang MD, PhD   +6 more
doaj   +1 more source

Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

Pharmacology Research & Perspectives, 2023
HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese ...
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu   +9 more
doaj   +1 more source

Differential impact of osteoporosis, sarcopenia and obesity on physical performance in aging men

Endocrine Connections, 2021
Purpose: Aging and concurrent constitutional changes as sarcopenia, osteoporosis and obesity are associated with progressive functional decline. Coincidence and mutual interference of this risk factors require further evaluation.
Franca Genest, Michael Schneider, Andreas Zehnder, Dominik Lieberoth-Leden, Lothar Seefried   +4 more
doaj   +1 more source

Co-expression and prognosis analyses of GLUT1–4 and RB1 in breast cancer

BMC Cancer, 2021
Background Current treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively poor.
Xiaodan Zhang, Xiaocong Pang, Zhuo Zhang, Qianxin Liu, Hanxu Zhang, Qian Xiang, Yimin Cui   +6 more
doaj   +1 more source

Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative. [PDF]

, 2018
Enrollment of children into pediatric clinical trials remains challenging. More effective strategies to improve recruitment of children into trials are needed.
Benjamin, Daniel K, Bloom, Diane, Bradley, John, Gamel, Breck, Greenberg, Rachel G, Hinton, Denise, Jafri, Hasan S, Nambiar, Sumathi, Roberts, Jamie, Smith, P Brian, Tiernan, Rosemary, Wheeler, Chris   +11 more
core   +5 more sources

Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201

CPT: Pharmacometrics & Systems Pharmacology, 2023
PB‐201 is the second glucokinase activator in the world to enter the phase III clinical trials for the treatment of type 2 diabetes mellitus (T2DM).
Miao Zhang, Zihan Lei, Ziheng Yu, Xueting Yao, Haiyan Li, Min Xu, Dongyang Liu   +6 more
doaj   +1 more source

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed.
Ling Li, Wei Zhang, Yu Hu, Xunliang Tong, Shangen Zheng, Juntao Yang, Yujie Kong, L. Ren, Qing Wei, H. Mei, Caiying Hu, Cuihua Tao, Ruoyu Yang, Jue Wang, Yongpei Yu, Yong Guo, Xiaoxiong Wu, Zhihua Xu, Li-Qin Zeng, N. Xiong, Lifeng Chen, Juan Wang, N. Man, Yu Liu, Haixia Xu, E. Deng, Xuejun Zhang, Chenyue Li, Conghui Wang, Shisheng Su, Linqi Zhang, Jianwei Wang, Yanyun Wu, Zhong Liu   +33 more
semanticscholar   +1 more source

The prevention and treatment of COVID-19 in patients treated with hemodialysis

European Journal of Medical Research, 2023
Patients treated with hemodialysis are often immunocompromised due to concomitant disease. As a result, this population is at high risk of infection and mortality from COVID-19.
Binyu Zeng, Jia Zhou, Daizhuang Peng, Chengmei Dong, Qun Qin   +4 more
doaj   +1 more source