Results 1 to 10 of about 3,517,837 (186)

Clinical trials [PDF]

, 2016
Phillips, Patrick PJ, Nunn, Andrew J
openaire   +4 more sources

Clinical trial recruiters’ experiences working with trial eligibility criteria: results of an exploratory, cross-sectional, online survey in the UK

Trials, 2021
Background Eligibility criteria are a fundamental element of clinical trial design, defining who can and who should not participate in a trial. Problems with the design or application of criteria are known to occur and pose risks to participants’ safety ...
William J. Cragg, Kathryn McMahon, Jamie B. Oughton, Rachel Sigsworth, Christopher Taylor, Vicky Napp   +5 more
doaj   +1 more source

Implications of analysing time-to-event outcomes as binary in meta-analysis: empirical evidence from the Cochrane Database of Systematic Reviews

BMC Medical Research Methodology, 2022
Background Systematic reviews and meta-analysis of time-to-event outcomes are frequently published within the Cochrane Database of Systematic Reviews (CDSR). However, these outcomes are handled differently across meta-analyses.
Theodosia Salika, Rebecca M. Turner, David Fisher, Jayne F. Tierney, Ian R. White   +4 more
doaj   +1 more source

How can health economics be used in the design and analysis of adaptive clinical trials? A qualitative analysis [PDF]

, 2020
Introduction Adaptive designs offer a flexible approach, allowing changes to a trial based on examinations of the data as it progresses. Adaptive clinical trials are becoming a popular choice, as the prudent use of finite research budgets and accurate ...
Brennan, Alan, Flight, Laura, Hind, Daniel, Julious, Steven, Todd, Susan Todd   +4 more
core   +2 more sources

Handling an uncertain control group event risk in non-inferiority trials: non-inferiority frontiers and the power-stabilising transformation

Trials, 2020
Background Non-inferiority trials are increasingly used to evaluate new treatments that are expected to have secondary advantages over standard of care, but similar efficacy on the primary outcome.
Matteo Quartagno, A. Sarah Walker, Abdel G. Babiker, Rebecca M. Turner, Mahesh K. B. Parmar, Andrew Copas, Ian R. White   +6 more
doaj   +1 more source

The Smooth Away From Expected (SAFE) non-inferiority frontier: theory and implementation with an application to the D3 trial

Trials, 2023
Background In a non-inferiority trial, the choice of margin depends on the expected control event risk. If the true risk differs from expected, power and interpretability of results can be affected. A non-inferiority frontier pre-specifies an appropriate
Matteo Quartagno, Man Chan, Anna Turkova, Deborah Ford, Ian R. White   +4 more
doaj   +1 more source

A patient-reported pressure ulcer health-related quality of life instrument for use in prevention trials (PU-QOL-P): psychometric evaluation

Health and Quality of Life Outcomes, 2018
Introduction Pressure ulcer-specific patient-reported outcome (PRO) instruments should be used to inform patient care and provide a strong evidence base for interventions aimed at preventing pressure ulcers.
Claudia Rutherford, Julia M. Brown, Isabelle Smith, Elizabeth McGinnis, Lyn Wilson, Rachael Gilberts, Sarah Brown, Susanne Coleman, Howard Collier, Jane Nixon   +9 more
doaj   +1 more source

Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 African sites.

PLoS Medicine, 2014
BackgroundA malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at 11 African sites with varying malaria transmission ...
RTS,S Clinical Trials Partnership
doaj   +1 more source

Duplicated network meta-analysis in advanced prostate cancer: a case study and recommendations for change

Systematic Reviews, 2022
Background Research overlap and duplication is a recognised problem in the context of both pairwise and network systematic reviews and meta-analyses.
David J. Fisher, Sarah Burdett, Claire Vale, Ian R. White, Jayne F. Tierney   +4 more
doaj   +1 more source

Cancer Clinical Trials Optimization and Pharmacogenomics [PDF]

, 2012
A critical overview of recent clinical trials in cancer is presented focused on signaling pathways blockers or inhibitors with a view to developing successful clinical trials employing personalized cancer therapies.
I. C. Baianu
core   +2 more sources