Results 1 to 10 of about 14,066,519 (402)

Matching Patients to Clinical Trials with Large Language Models [PDF]

Nature Communications, 2023
Patient recruitment is challenging for clinical trials. We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models.
Qiao Jin, Zifeng Wang, C. Floudas, Jimeng Sun, Zhiyong Lu   +4 more
semanticscholar   +1 more source

Clinical trials and clinical trials networks

Respirology
Ary Serpa Neto, Rinaldo Bellomo
openaire   +3 more sources

Clinical Trials [PDF]

, 2016
Nunn, Andrew J, Phillips, Patrick PJ
core   +3 more sources

Emulation of Randomized Clinical Trials With Nonrandomized Database Analyses: Results of 32 Clinical Trials.

Journal of the American Medical Association (JAMA), 2023
Importance Nonrandomized studies using insurance claims databases can be analyzed to produce real-world evidence on the effectiveness of medical products.
Shirley V. Wang, S. Schneeweiss, J. Franklin, R. Desai, W. Feldman, E. Garry, R. Glynn, K. J. Lin, Julie M. Paik, Elisabetta Patorno, S. Suissa, Elvira D'Andrea, Dureshahwar Jawaid, Hemin Lee, Ajinkya M Pawar, S. K. Sreedhara, Helen Tesfaye, Lily G. Bessette, Luke E. Zabotka, Su Been Lee, N. Gautam, Cassie York, Heidi Zakoul, J. Concato, David Martin, Dianne Paraoan, K. Quinto   +26 more
semanticscholar   +1 more source

MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies

Experimental and Molecular Medicine, 2023
As a type of short noncoding RNAs, microRNA (miRNA) undoubtedly plays a crucial role in cancer development. Since the discovery of the identity and clinical functions of miRNAs, over the past few decades, the roles of miRNAs in cancer have been actively ...
Taewan Kim, C. Croce
semanticscholar   +1 more source

A review on exosomes application in clinical trials: perspective, questions, and challenges

Cell Communication and Signaling, 2022
Background Exosomes are progressively known as significant mediators of cell-to-cell communication. They convey active biomolecules to target cells and have vital functions in several physiological and pathological processes, and show substantial promise
J. Rezaie, Maryam Feghhi, Tahereh Etemadi   +2 more
semanticscholar   +1 more source

Targeting fibrosis: mechanisms and clinical trials

Signal Transduction and Targeted Therapy, 2022
Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung.
Manyu Zhao, Liqun Wang, Mengzhu Wang, Shijie Zhou, Ying Lu, H. Cui, A. Racanelli, Ling Zhang, Tinghong Ye, Bisen Ding, Ben Zhang, Jinliang Yang, Yuqin Yao   +12 more
semanticscholar   +1 more source

Clinical trial recruiters’ experiences working with trial eligibility criteria: results of an exploratory, cross-sectional, online survey in the UK

Trials, 2021
Background Eligibility criteria are a fundamental element of clinical trial design, defining who can and who should not participate in a trial. Problems with the design or application of criteria are known to occur and pose risks to participants’ safety ...
William J. Cragg, Kathryn McMahon, Jamie B. Oughton, Rachel Sigsworth, Christopher Taylor, Vicky Napp   +5 more
doaj   +1 more source

Implications of analysing time-to-event outcomes as binary in meta-analysis: empirical evidence from the Cochrane Database of Systematic Reviews

BMC Medical Research Methodology, 2022
Background Systematic reviews and meta-analysis of time-to-event outcomes are frequently published within the Cochrane Database of Systematic Reviews (CDSR). However, these outcomes are handled differently across meta-analyses.
Theodosia Salika, Rebecca M. Turner, David Fisher, Jayne F. Tierney, Ian R. White   +4 more
doaj   +1 more source

Promoting inclusion in clinical trials—a rapid review of the literature and recommendations for action

Trials, 2021
Background Without inclusion of diverse research participants, it is challenging to understand how study findings will translate into the real world. Despite this, a lack of inclusion of those from under-served groups in research is a prevailing problem ...
D. Bodicoat, A. Routen, A. Willis, W. Ekezie, C. Gillies, C. Lawson, T. Yates, F. Zaccardi, M. Davies, K. Khunti   +9 more
semanticscholar   +1 more source