Results 31 to 40 of about 14,066,519 (402)

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network [PDF]

, 2009
Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.
Frölich, Lutz, Gertz, Hermann-Josef, Hampel, Harald, Henn, Fritz, Heuser, Isabella, Huell, Michael, Jahn, Holger, Jessen, Frank, Kornhuber, Johannes, Luckhaus, Christian, Maier, Wolfgang, Pantel, Johannes, Perneczky, Robert, Peters, Oliver, Rienhoff, Otto, Ruüther, Eckart, Schmidtke, Klaus, Schroeder, Johannes, Seuchter, Susanne A., Weih, Markus, Wiltfang, Jens, Wolf, Stefanie   +21 more
core   +1 more source

COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials

Nature Reviews Clinical Oncology, 2021
Emerging efficacy data have led to the emergency use authorization or approval of COVID-19 vaccines in several countries worldwide. Most trials of COVID-19 vaccines excluded patients with active malignancies, and thus data on the safety, tolerability and
A. Desai, J. Gainor, A. Hegde, A. Schram, G. Curigliano, S. Pal, Stephen V. Liu, B. Halmos, R. Groisberg, E. Grande, T. Dragovich, M. Matrana, N. Agarwal, S. Chawla, S. Kato, G. Morgan, P. Kasi, B. Solomon, H. Loong, Haeseong Park, T. Choueiri, I. Subbiah, N. Pemmaraju, V. Subbiah   +23 more
semanticscholar   +1 more source

Paying clinicians to join clinical trials : a review of guidelines and interview study of trialists [PDF]

, 2009
Background: The motivations of clinicians to participate in clinical trials have been little studied. This project explored the potential role of payment for participation in publicly funded clinical trials in the UK.
Association of British Pharmaceutical Industries, British Medical Association, Christine Kerr, Clinical Research Report, D Fayter, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, General Medical Council, J Bryant, James Raftery, John Powell, ME Charlson, Medical Research Council, Nvivo, RJ Prescott, S Asch, S Hawker, Sheila Hawker, V Peto, WJ Jack   +23 more
core   +3 more sources

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

British Journal of Cancer, 1977
Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the ...
R. Peto, M. Pike, P. Armitage, N. Breslow, D. Cox, S. V. Howard, N. Mantel, K. McPherson, J. Peto, Peter Smith   +9 more
semanticscholar   +1 more source

This is a platform alteration: a trial management perspective on the operational aspects of adaptive and platform and umbrella protocols

Trials, 2019
Background There are limited research and literature on the trial management challenges encountered in running adaptive platform trials. This trial design allows both (1) the seamless addition of new research comparisons when compelling clinical and ...
Francesca Schiavone, Riya Bathia, Krishna Letchemanan, Lindsey Masters, Claire Amos, Anna Bara, Louise Brown, Clare Gilson, Cheryl Pugh, Nafisah Atako, Fleur Hudson, Mahesh Parmar, Ruth Langley, Richard S. Kaplan, Chris Parker, Gert Attard, Noel W. Clarke, Silke Gillessen, Nicholas D. James, Tim Maughan, Matthew R. Sydes, On behalf of past and present members of the STAMPEDE and FOCUS4 Trial Management Group   +21 more
doaj   +1 more source

Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative. [PDF]

, 2018
Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to ...
Benjamin, Daniel K, Bradley, John, Corneli, Amy, Farley, John, Greenberg, Rachel G, Jafri, Hasan S, Lin, Li, Nambiar, Sumathi, Noel, Gary J, Roberts, Jamie, Smith, P Brian, Tiernan, Rosemary, Wheeler, Chris   +12 more
core   +2 more sources

Experience and Challenges from Clinical Trials with Malaria Vaccines in Africa. [PDF]

, 2013
Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort by many groups over the last few decades ...
A Nyika, A Olotu, A Roca-Feltrer, AA Holder, AJ Luty, AVS Hill, B Moonen, Bernhards Ogutu, Beverly Msambichaka, BF Chumpitazi, Bouharoun-Tayoun H Druilhe P, C Guinovart, C Roussilhon, C Swysen, DA Chokshi, DA Diallo, E Peduzzi, Eakin, Bull SS, Riley K,Reeves MM, Gutierrez S, McLaughlin P, FM Ndungu, FM Ndungu, FM Thompson, Grace Mwangoka, H Bouharoun-Tayoun, HL Smits, I Nebie, J Schantz-Dunn, JL Sarthou, K Miura, K Shubis, KE Kester, KE Kester, KP Asante, L Schwartz, M Roestenberg, M Roestenberg, Marcel Tanner, Maxmillian Mpina, MP Girad, Nahya Salim, NC Iriemenam, NJ White, OK Doumbo, PG Cech, PL Alonso, PL Alonso, PL Alonso, PO Tindana, R Chilengi, RR Taylor, S Casares, Salim Abdulla, Seif Shekalaghe, Shubis Kafuruki, SJ Rogerson, SL Hoffman, ST Agnandji, ST Agnandji, T Smith, T Smith, T Smith, TA Lang, The malERA Consultative Group on Vaccines, Tutu Mzee, V Gardette, V Moorthy, WHO, WHO, YP Shi   +67 more
core   +3 more sources

When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts

BMC Medical Research Methodology, 2017
BackgroundMissing data may seriously compromise inferences from randomised clinical trials, especially if missing data are not handled appropriately. The potential bias due to missing data depends on the mechanism causing the data to be missing, and the ...
J. Jakobsen, C. Gluud, J. Wetterslev, P. Winkel   +3 more
semanticscholar   +1 more source

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials.

Journal of the American Medical Association (JAMA), 2020
Importance A vaccine against coronavirus disease 2019 (COVID-19) is urgently needed. Objective To evaluate the safety and immunogenicity of an investigational inactivated whole-virus COVID-19 vaccine in China.
S. Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Z. Xie, Xinguo Li, Cheng Peng, Yanbo Zhang, Wei Zhang, Y. Yang, Wei Chen, Xiaoxiao Gao, W. You, Xuewei Wang, Zejun Wang, Zhengli Shi, Yanxia Wang, Xuqin Yang, Lianghao Zhang, Lili Huang, Qian Wang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, X. Wan, Cong Wu, Wenhui Wang, Shihe Huang, Jianhui Du, Z. Meng, A. Pan, Zhiming Yuan, S. Shen, Wanshen Guo, Xiaoming Yang   +36 more
semanticscholar   +1 more source

Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement.

Clinical Cancer Research, 2021
Therapeutic advances for glioblastoma have been minimal over the past two decades. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early phase programs, a Society ...
S. Bagley, S. Kothari, R. Rahman, E. Lee, G. Dunn, E. Galanis, Susan M. Chang, L. Nabors, M. Ahluwalia, R. Stupp, M. Mehta, D. Reardon, S. Grossman, E. Sulman, J. Sampson, S. Khagi, M. Weller, T. Cloughesy, P. Wen, M. Khasraw   +19 more
semanticscholar   +1 more source