Results 51 to 60 of about 324,514 (339)
Targeting mTOR in Pancreatic Ductal Adenocarcinoma
Frontiers in Oncology, 2016 Treatment options for advanced pancreatic ductal adenocarcinoma (PDAC) are limited, however, new therapies targeting specific tumor-related molecular characteristics may help certain patient cohorts. Emerging preclinical data has shown that inhibition of
Sentia eIriana +6 more
doaj +1 more source
An alternative approach to deal with the absence of clinical trials: a proportional meta-analysis of case series studies [PDF]
Acta Cirúrgica Brasileira, 2013 PURPOSE: Systematic reviews are criticized for frequently offering inconsistent evidences and absence of straightforward recommendations. Their value seems to be depreciated when the conclusions are uncertain.
Regina El Dib +2 more
doaj +2 more sources
Topical Tacrolimus for High-risk Corneal Transplantation: A randomized, clinical trial
BMC Ophthalmology, 2022 Abstract Immunological rejection after high-risk penetrating keratoplasty (PKP) remains a major problem. We investigated the efficacy and safety of topical tacrolimus (TAC) in these patients. This randomised clinical trial performed at a tertiary referral hospital included eyes of patients with a history of PKP, graft rejection, atopic ...
Shimazaki, J +4 more
openaire +4 more sources
Trials, 2017 BackgroundImplementing the treatment arm of a clinical trial often requires changes to healthcare practices. Barriers to such changes may undermine the delivery of the treatment making it more likely that the trial will demonstrate no treatment effect ...
J. Presseau +7 more
semanticscholar +1 more source
Exosomes and Immune Response in Cancer: Friends or Foes?
Frontiers in Immunology, 2018 Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent years. This led to the understanding that these structures, far from being inert waste by-products of cellular functioning, are active players in intercellular ...
Francisco M. Barros +10 more
doaj +1 more source
Drug Design, Development and Therapy, 2015 Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma.To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma.In a parallel randomized clinical trial, 74 women with melasma were allocated to ...
Hassan Adalatkhah +1 more
openaire +6 more sources
Protecting patient privacy when sharing patient-level data from clinical trials
BMC Medical Research Methodology, 2016 BackgroundGreater transparency and, in particular, sharing of patient-level data for further scientific research is an increasingly important topic for the pharmaceutical industry and other organisations who sponsor and conduct clinical trials as well as
K. Tucker +6 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Double-blind clinical trial of topical steroids in anterior uveitis. [PDF]
British Journal of Ophthalmology, 1979 We present the results of a double-blind trial comparing the efficacy of betamethasone phosphate 0.1%, clobetasone butyrate 0.1%, and placebo in the treatment of acute unilateral nongranulomatous uveitis. The 2 steroids were equally comparable in improvement of the patients' symptoms, though betamethasone phosphate was significantly more effective than
J A Dunne, J P Travers
openaire +3 more sources