Results 61 to 70 of about 1,905,942 (404)
Targeting mTOR in Pancreatic Ductal Adenocarcinoma
Frontiers in Oncology, 2016 Treatment options for advanced pancreatic ductal adenocarcinoma (PDAC) are limited, however, new therapies targeting specific tumor-related molecular characteristics may help certain patient cohorts. Emerging preclinical data has shown that inhibition of
Sentia eIriana +6 more
doaj +1 more source
Inadequate reporting quality of registered genome editing trials: an observational study
BMC Medical Research Methodology, 2022 Background To assess registration completeness and safety data of trials on human genome editing (HGE) reported in primary registries and published in journals, as HGE has safety and ethical problems, including the risk of undesirable and unpredictable ...
Diana Jurić +2 more
doaj +1 more source
Estimating Design Operating Characteristics in Bayesian Adaptive Clinical Trials [PDF]
arXiv, 2021 Bayesian adaptive designs have gained popularity in all phases of clinical trials with numerous new developments in the past few decades. During the COVID-19 pandemic, the need to establish evidence for the effectiveness of vaccines, therapeutic treatments and policies that could resolve or control the crisis emphasized the advantages offered by ...
arxiv
Protecting patient privacy when sharing patient-level data from clinical trials
BMC Medical Research Methodology, 2016 BackgroundGreater transparency and, in particular, sharing of patient-level data for further scientific research is an increasingly important topic for the pharmaceutical industry and other organisations who sponsor and conduct clinical trials as well as
K. Tucker +6 more
semanticscholar +1 more source
Topical Tacrolimus for High-risk Corneal Transplantation: A randomized, clinical trial
BMC Ophthalmology, 2022 Abstract Immunological rejection after high-risk penetrating keratoplasty (PKP) remains a major problem. We investigated the efficacy and safety of topical tacrolimus (TAC) in these patients. This randomised clinical trial performed at a tertiary referral hospital included eyes of patients with a history of PKP, graft rejection, atopic ...
Jun Shimazaki +4 more
openaire +3 more sources
A systematic review of school-based alcohol and other drug prevention programs [PDF]
, 2015 Background: Alcohol use in adolescents constitutes a major public health concern. Europe is the heaviest drinking region of the world. Several school-based alcohol prevention programs have been developed but it is not clear whether they are really ...
Agabio R +5 more
core +1 more source
Exosomes and Immune Response in Cancer: Friends or Foes?
Frontiers in Immunology, 2018 Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent years. This led to the understanding that these structures, far from being inert waste by-products of cellular functioning, are active players in intercellular ...
Francisco M. Barros +10 more
doaj +1 more source
Annals of Oncology, 2017 The Gynecologic Cancer InterGroup (GCIG) Fifth Ovarian Cancer Consensus Conference (OCCC) was held in Tokyo, Japan from 7 to 9 November 2015. It provided international consensus on 15 important questions in 4 topic areas, which were generated in ...
M. Bookman +13 more
semanticscholar +1 more source
Drug Design, Development and Therapy, 2015 Treatment of melasma is unsatisfactory most of the times. Hormonal role is shown to exist in pathogenesis of the melasma, and sex-hormone related drugs may have an effect on melasma.To investigate efficacy of 1% flutamide cream versus 4% hydroquinone cream on melasma.In a parallel randomized clinical trial, 74 women with melasma were allocated to ...
Hassan Adalatkhah +1 more
openaire +7 more sources