Results 81 to 90 of about 608,159 (405)
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source
A clinical trial of topical 10% trolamine salicylate in osteoarthritis
Abstract This short-term, double-blind, placebo-controlled, crossover study evaluated the effectiveness of 10% trolamine salicylate in a cream base as a topical analgesic compared with placebo. Fifty patients with pain and stiffness because of osteoarthritis in their hands participated in the study; 49 patients completed the study.
Constance Difigilo +2 more
openaire +2 more sources
The future of European Nephrology 'Guidelines' - a declaration of intent by European Renal Best Practice (ERBP) [PDF]
The disparities of medical practice, together with a growing number of possible interventions, have increased the demand for well-conceived guidance for practitioners [1].
Abramowicz, Daniel +20 more
core +1 more source
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Welcome to the fi rst edition of the Clinical Trials Corner of Nutrition and Healthy Aging. The aim of this section is to inform readers of upcoming clinical trials and highlight new fi ndings. If you would like to draw attention to a specifi c topic and
L. Heilbronn
semanticscholar +1 more source
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Background Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials. Methods We used a mixed methods design,
Hamm Michele P +4 more
doaj +1 more source
Health topics emerged from brief‐motivational interviewing: A randomized clinical trial [PDF]
Michelle C Arnett +4 more
openalex +1 more source
Routinely administered questionnaires for depression and anxiety : systematic review [PDF]
Objectives To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings.
Gilbody, S M, House, A O, Sheldon, T A
core +2 more sources
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source

