Results 81 to 90 of about 1,939,729 (406)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

A clinical trial of topical 10% trolamine salicylate in osteoarthritis

Current Therapeutic Research, 1994
Abstract This short-term, double-blind, placebo-controlled, crossover study evaluated the effectiveness of 10% trolamine salicylate in a cream base as a topical analgesic compared with placebo. Fifty patients with pain and stiffness because of osteoarthritis in their hands participated in the study; 49 patients completed the study.
Constance Difigilo, Ilbok Lee, Dana Quinn Rothacker   +2 more
openaire   +2 more sources

Structured review of the patient-reported outcome instruments used in clinical trials in head and neck surgery [PDF]

, 2018
The number of clinical trials that relate to patients with cancer of the head and neck is growing. Patient-reported outcomes, which are rarely the primary outcome, are now an important component, and in this structured review to identify and report the ...
Barraclough, J, Boyes, H, Kanatas, A, Ratansi, R, Rogers, SN   +4 more
core   +2 more sources

Clinical trial site matching with improved diversity using fair policy learning [PDF]

arXiv, 2022
The ongoing pandemic has highlighted the importance of reliable and efficient clinical trials in healthcare. Trial sites, where the trials are conducted, are chosen mainly based on feasibility in terms of medical expertise and access to a large group of patients.
arxiv  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Calcific uraemic arteriolopathy - A mini-review [PDF]

, 2016
Calcific Uraemic Arteriolopathy (CUA) or calciphylaxis, is a thrombotic disorder of skin and subcutaneous tissue which typically presents with painful purpuric nodules that may progress to necrotic ulcers, and is a severe, life-threatening condition. CUA
Agapii, Rodica, Fragoso, Andr?, Jerónimo, Teresa, Mendes, Filipa, Neves, Pedro L, Pimentel, Ana, Rocha, Sofia Couto, Silva, Ana   +7 more
core  

Quality and Publication of Emergency Medicine Trials Registered in ClinicalTrials.gov [PDF]

, 2020
Introduction: Promoting emergency medicine (EM) clinical trials research remains a priority. To characterize the status of clinical EM research, this study assessed trial quality, funding source, and publication of EM clinical trials and compared EM and ...
Calvocoressi, Lisa, Carroll, Megan, Dziura, James, Johnson, Benjamin, Post, Lori, Reynolds, Jesse, Vaca, Federico E., Warzoha, Meghan M.   +7 more
core  

ReseArch with Patient and Public invOlvement: a RealisT evaluation - the RAPPORT study [PDF]

, 2015
Background Patient and public involvement (PPI) is a prerequisite for many funding bodies and NHS research ethics approval. PPI in research is defined as research carried out with or by the public rather than to, about or for them.
Abbott, Abma, All-Party Parliamentary Group, Andejeski, Armes, Astbury, Badger, Baggott, Baggott, Barber, Barber, Barber, Barbour, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Batsch, Baxter, Ben-Ari, Beresford, Bhaskar, Boivin, Boote, Boote, Boote, Boote, Brannen, Brett, Brett, Brett, British Paediatric Surveillance Unit, Broerse, Burrus, Cairncross, Caldon, Callard, Caron-Flinterman, Carter, Chalmers, Clark, Clavier, Collaboration for Leadership in Applied Health Research and Care, Collier, Connelly, Connelly, Consumers Health Forum of Australia, Cotterell, Cotterell, Cystic Fibrosis Trust, Davis, Davis, Delanty, Delbanco, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Dewar, Edwards, Elberse, Entwistle, Entwistle, Evans, Expert Patients Programme, Exworthy, Fairbrother, Faulkner, Fiss, Forbat, Forbes, Fulop, Gibson, Goodman, Goodman, Gradinger, Great Britain, Greene, Guarino, Habermas, Habermas, Habermas, Hartley, Hawe, Hayes, Held, Hewitt, Hewlett, Higher Education Funding Council for England, HM Government, HM Government, Hofmann, Howe, Howe, Hunn, Hunt, Iliffe, INVOLVE, INVOLVE, Ives, Jagosh, Jagosh, Jordan, Kontos, Koops, Kreindler, Kreis, Krieger, Langston, Lasker, Lindenmeyer, Lupton, Macaulay, Marchal, Marinetto, Martin, Martin, Mathie, Matthews, May, May, May, May, McCormick, McDonnell, McGrath, McKevitt, McKevitt, McNichol, Medical Research Council, Merton, Meyer, Middleton, Miller, Milton, Minogue, Morrow, Nathan, National Cancer Research Institute, National Institute of Health Research, National Institutes of Health, National Voices, Ocloo, Oliver, Oliver, Oliver, Oliver, O’Cathain, O’Donnell, Palmer, Parkes, Paterson, Patient and Public Involvement Solutions, Pattengill-Semmens, Pawson, Pawson, Pawson, Peckham, Philpot, PiiAF Study Group, Pitt, Prior, Purttell, Renedo, Research Design Service London, Rhodes, Roderick, Royal College of Psychiatry, Royle, Rycroft-Malone, Rycroft-Malone, Savage, Schierhout, Schneider, Schwappach, Scott, Shippee, Shirk, Smith, Snape, Staley, Staley, Staley, Staley, Staniszewska, Staniszewska, Staniszewska, Staniszewska, Staniszewska, Stevens, Strauss, Sutton, Telford, Telford, Terry, Thompson, Thompson, Thompson, Titmuss, Tolson, Tritter, Truman, Vale, van Bekkum, Walker, Wand, Ward, Williams, Williams, Williamson, Wilson, Wilson, Wilson, Wilson, World Health Organization, Wright, Yin   +225 more
core   +3 more sources

Which Obstacles Prevent Us from Recruiting into Clinical Trials: A Survey about the Environment for Clinical Studies at a German University Hospital in a Comprehensive Cancer Center

Frontiers in Oncology, 2017
BackgroundProspective clinical studies are the most important tool in modern medicine. The standard in good clinical practice in clinical trials has constantly improved leading to more sophisticated protocols.
Christoph Straube, Christoph Straube, Christoph Straube, Peter Herschbach, Peter Herschbach, Peter Herschbach, Stephanie E. Combs, Stephanie E. Combs, Stephanie E. Combs, Stephanie E. Combs   +9 more
doaj   +1 more source

Clinical Trials Corner

Nutrition and Healthy Aging, 2017
Welcome to the fi rst edition of the Clinical Trials Corner of Nutrition and Healthy Aging. The aim of this section is to inform readers of upcoming clinical trials and highlight new fi ndings. If you would like to draw attention to a specifi c topic and
L. Heilbronn
semanticscholar   +1 more source