Results 81 to 90 of about 612,154 (364)

The role of machine learning in clinical research: transforming the future of evidence generation

Trials, 2021
Background Interest in the application of machine learning (ML) to the design, conduct, and analysis of clinical trials has grown, but the evidence base for such applications has not been surveyed.
E. Hope Weissler, Tristan Naumann, Tomas Andersson, Rajesh Ranganath, Olivier Elemento, Yuan Luo, Daniel F. Freitag, James Benoit, Michael C. Hughes, Faisal Khan, Paul Slater, Khader Shameer, Matthew Roe, Emmette Hutchison, Scott H. Kollins, Uli Broedl, Zhaoling Meng, Jennifer L. Wong, Lesley Curtis, Erich Huang, Marzyeh Ghassemi   +20 more
doaj   +1 more source

Cochrane acute respiratory infections group's stakeholder engagement project identified systematic review priority areas [PDF]

, 2018
Objective: Cochrane acute respiratory infections (ARIs) group conducts systematic reviews of the evidence for treatment and prevention of ARIs. We report the results of a prioritization project, aiming to identify highest priority systematic review ...
Clark, Justin, Del Mar, Chris, Dooley, Liz, Jones, Ann, Jones, Mark, Scott, Anna Mae   +5 more
core   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Translational concepts of mGluR5 in synaptic diseases of the brain

Frontiers in Pharmacology, 2012
The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information.
Thomas M Piers, Dong Hyun eKim, Byeong C Kim, Byeong C Kim, Philip eRegan, Philip eRegan, Philip eRegan, Daniel John Whitcomb, Kwangwook eCho, Kwangwook eCho   +9 more
doaj   +1 more source

Supporting professional learning in a massive open online course [PDF]

, 2014
Professional learning, combining formal and on the job learning, is important for the development and maintenance of expertise in the modern workplace.
Littlejohn, Allison, Milligan, Colin
core   +5 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Vitamin D for the Treatment of Epilepsy: Basic Mechanisms, Animal Models and Clinical Trials

Frontiers in Neurology, 2016
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids.
Kevin Pendo, Christopher Michael DeGiorgio, MD   +1 more
doaj   +1 more source

Lessons learned from two randomized controlled trials: CITIES and STOP-DKD

Contemporary Clinical Trials Communications, 2020
Background: Even well-designed, theoretically driven clinical trials can fall short of achieving the desired clinical outcomes. Our research team had an opportunity to conduct two randomized controlled trials that were enrolling patients in parallel ...
Leah L. Zullig, Megan M. Oakes, Felicia McCant, Hayden B. Bosworth   +3 more
doaj   +1 more source

Developing a topic-based repository of clinical trial individual patient data: experiences and lessons learned from a pilot project [PDF]

, 2021
Nancy Medley, Anna Cuthbert, Richard Crew, Lesley Stewart, Catrin Tudur Smith, Žarko Alfirević   +5 more
openalex   +1 more source