Results 31 to 40 of about 3,979 (194)
Effect of levodopa and clioquinol on antioxidant capacity in Parkinson’s disease rhesus monkeys
浙江大学学报. 农业与生命科学版, 2017 Parkinson’s disease (PD), characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the brain, is the second most common neurodegenerative disease.
LI Like +7 more
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Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution [PDF]
, 2016 Copper-ionophores that elevate intracellular bioavailable copper display significant therapeutic utility against prostate cancer cells in vitro and in TRAMP (Transgenic Adenocarcinoma of Mouse Prostate) mice.
Cater, Michael A. +10 more
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New insights into the mechanism of antifungal action of 8-hydroxyquinolines
Saudi Pharmaceutical Journal, 2019 The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel derivatives endowed with biological activity. Our research aimed at clarifying the antifungal mechanism of action of clioquinol, 8-hydroxy-5-quinolinesulfonic ...
Bruna Pippi +9 more
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Parasite, 2020 A clioquinol (ICHQ)-containing Pluronic® F127 polymeric micelle system (ICHQ/Mic) was recently shown to be effective against Leishmania amazonensis infection in a murine model. In the present study, ICHQ/Mic was tested against L. infantum infection. BALB/
Tavares Grasiele S.V. +21 more
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, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
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Amyloid Plaques Beyond Aβ: A Survey of the Diverse Modulators of Amyloid Aggregation [PDF]
, 2017 Aggregation of the amyloid-β (Aβ) peptide is strongly correlated with Alzheimer’s disease (AD). Recent research has improved our understanding of the kinetics of amyloid fibril assembly and revealed new details regarding different stages in plaque ...
A Abelein +180 more
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Cyclic AMP pathway activation and extracellular zinc induce rapid intracellular zinc mobilization in Candida albicans [PDF]
, 2018 LK was supported by Innovation Fund Denmark, DK (4019-00019B). Pcovery ApS received funding from Wellcome Trust, Research Councils, UK (100480/Z/12), Novo Seeds, DK and Boehringer Ingelheim Venture Fund, D.
Anja T. Fuglsang +4 more
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Smart systems related to polypeptide sequences [PDF]
, 2016 Increasing interest for the application of polypeptide-based smart systems in the biomedical field has developed due to the advantages given by the peptidic sequence.
Franco García, María Lourdes +2 more
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The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease [PDF]
, 2014 Brain aging is marked by structural, chemical, and genetic changes leading to cognitive decline and impaired neural functioning. Further, aging itself is also a risk factor for a number of neurodegenerative disorders, most notably Alzheimer's disease (AD)
Aizenman, E, McCord, MC
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Journal of Global Antimicrobial Resistance, 2020 Objectives: The incidence of severe filamentous fungal infections has increased over the past decade. Some of these filamentous fungi are resistant to available antifungals; it is thus urgent to find new compounds that are active against such life ...
Hanane Yousfi +4 more
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