Results 61 to 70 of about 3,979 (194)

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, Volume 8, Issue 9, September 2025.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
Mitochondria play a critical role in aging and aging‐related diseases. This review systematically explores the mechanisms underlying mitochondrial deterioration during aging and highlights innovative therapeutic strategies for these mitochondrial problems.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
wiley   +1 more source

Estudio de la dermatitis por contacto alérgica mediante pruebas del parche, Serie Estándar Europea, en el Departamento de Dermatología del Hospital Universitario “Dr. José Eleuterio González”, UANL [PDF]

, 2008
Antecedentes: La dermatitis por contacto es causada por la exposición a sustancias que actúan como alergenos, irritantes primarios, o ambos. Las pruebas epicutáneas o del parche son útiles para su diagnóstico, sobre todo en casos con eczema crónico sin ...
Gutiérrez Terrazas, Teresa, Gómez Flores, Minerva, Herz Ruelas, Maira Elizabeth, Ocampo Candiani, Jorge   +3 more
core  

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability [PDF]

, 2017
Amyloid plaques consisting of aggregated Aβ peptide are a hallmark of Alzheimer's disease. Among the different forms of Aβ, the one of 42aa length (Aβ42) is most aggregation-prone and also the most neurotoxic.
Georgiev, Oleg, Harmeier, Anja, Hua, Haiqing, Multhaup, Gerd, Münter, Lisa, Schaffner, Walter   +5 more
core  

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity [PDF]

, 2015
The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing.
A Dillin, A Wong, AJ Whitmarsh, Alan J. Whitmarsh, AM Nargund, B Lakowski, BN Marbois, C Frezza, C Frokjaer-Jensen, C Lopez-Otin, C Yee, CE Riera, D Cristina, DA Hall, E Owusu-Ansah, E Zeiser, EB Kayser, F Levavasseur, FY Chueh, G Sutendra, G Wright, Gino B. Poulin, H Miyadera, J Yun, JE Aldridge, JJ Ewbank, JM Matés, JM Van Raamsdonk, K Itoh, Kate Fisher, KJ Livak, L Papa, LA Sena, LV O’Keefe, M Bar-Peled, MB Jensen, N Jiang, Nicholas Rooney, NS Chandel, O Yogev, O Yogev, OK Mirzoeva, RH Houtkooper, Richard M. Monaghan, Robert G. Barnes, S Brenner, S Felkai, S Suzuki, SJ Lee, SP Whelan, SW Tait, T Jonassen, T Jonassen, Tereza Andreou, TJ Schulz, VN Kotiadis, W Yang, X Liu, Y Wang   +58 more
core   +2 more sources

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

Loss‐of‐function polymorphisms in NQO1 are not associated with the development of subacute myelo‐optico‐neuropathy

Molecular Genetics & Genomic Medicine
Background Subacute myelo‐optico‐neuropathy (SMON) is a neurological disorder associated with the administration of clioquinol, particularly at very high doses. Although clioquinol has been used worldwide, there was an outbreak of SMON in the 1950s–1970s
Hideki Matsumoto, Hideo Sasai, Norio Kawamoto, Masato Katsuyama, Makoto Minamiyama, Satoshi Kuru, Toshiyuki Fukao, Hidenori Ohnishi, the SMON Research Group Members   +8 more
doaj   +1 more source

The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases

MedComm, Volume 6, Issue 6, June 2025.
Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu, Shiyuan Huang, Li Peng, Li Yang, Guosong Zhang, Tao Liu, Fang Yan, Xi Peng   +7 more
wiley   +1 more source

Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands

Frontiers in Chemical Biology
Introduction: Glioblastoma is a brain cancer difficult to treat but recently mixed-ligand vanadium(V) Schiff base/catecholato complexes have exhibited high in vitro anti-proliferative activity. Hence, we explored the activity of [VVOL1L2], which contains
Aviva Levina, Gonzalo Scalese, Gonzalo Scalese, Dinorah Gambino, Debbie C. Crans, Peter A. Lay   +5 more
doaj   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, Volume 45, Issue 5, Page 577-607, May 2025.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source