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Expression Patterns of Clock Gene mRNAs and Clock Proteins in Human Psoriatic Skin Samples [PDF]
International Journal of Molecular Sciences, 2021 Psoriasis is a systemic inflammatory skin disorder that can be associated with sleep disturbance and negatively influence the daily rhythm. The link between the pathomechanism of psoriasis and the circadian rhythm has been suggested by several previous studies. However, there are insufficient data on altered clock mechanisms in psoriasis to prove these
Viktória Németh +4 more
europepmc +4 more sources
Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms [PDF]
Proceedings of the National Academy of Sciences, 2020 ABSTRACTCircadian clocks regulate ∼24 hour oscillations in gene expression, behavior, and physiology. While the molecular and neural mechanisms of circadian rhythms are well characterized, how cellular organization of clock components controls circadian clock regulation remains poorly understood. Here, we elucidate how clock proteins regulate circadian
Yangbo Xiao +4 more
europepmc +6 more sources
Circadian Clock Proteins and Immunity [PDF]
Immunity, 2014 Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow an organism to anticipate daily changes in activity and feeding and the associated risk of infection or tissue damage to the host. Responses to bacteria have been shown to vary
Curtis A. M. +3 more
openaire +6 more sources
How is the inner circadian clock controlled by interactive clock proteins? [PDF]
FEBS Letters, 2015 Most internationally travelled researchers will have encountered jetlag. If not, working odd hours makes most of us feel somehow dysfunctional. How can all this be linked to circadian rhythms and circadian clocks? In this review, we define circadian clocks, their composition and underlying molecular mechanisms.
Eva Wolf, Torsten Merbitz-Zahradnik
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Expression of clock proteins in developing tooth [PDF]
Gene Expression Patterns, 2011 Morphological and functional changes during ameloblast and odontoblast differentiation suggest that enamel and dentin formation is under circadian control. Circadian rhythms are endogenous self-sustained oscillations with periods of 24h that control diverse physiological and metabolic processes.
Petros Papagerakis +4 more
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Molecular clock in neutral protein evolution [PDF]
BMC Genetics, 2004 Abstract Background A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean) substantially larger than one. This observation has been termed the overdispersed molecular clock.
Claus O. Wilke, Claus O. Wilke
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Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK [PDF]
BMC Molecular Biology, 2008 Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity.
Urs Albrecht +5 more
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The Clock Proteins, Aging, and Tumorigenesis [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2007 Many aspects of mammalian physiology and behavior are driven by an intrinsic timekeeping system that has an important role in synchronizing various biological processes within an organism and coordinating them with the environment. It is believed that deregulation of this coordination may cause the development of various pathologies.
R. V. Kondratov, M. P. Antoch
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SnapShot: Circadian Clock Proteins
Cell, 2008 The earth’s rotation about its axis generates predictable changes in light and temperature, which define the 24 hr day-night cycle. Organisms from bacteria to humans have evolved an internal timekeeper to anticipate these environmental changes. This timekeeper—the circadian clock—allows organisms to parse biological processes to the appropriate time of
Steve A. Kay, Elizabeth E. Hamilton
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Role of the CLOCK protein in liver detoxification [PDF]
British Journal of Pharmacology, 2019 Background and PurposeWhether and how circadian clock proteins regulate drug detoxification are not known. Here, we have assessed the effects of CLOCK (a core circadian clock protein) on drug metabolism and detoxification.Experimental ApproachRegulation by CLOCK protein of drug‐metabolizing enzymes was assessed using Clock knockout (Clock−/−) mice and ...
Mengjing Zhao +9 more
openaire +3 more sources