Results 101 to 110 of about 5,752,696 (345)
A scenario of unhealthy life cycle: The role of circadian rhythms in health
Aging MedicineCircadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli +2 more
doaj +1 more source
Real-Time In Vitro Fluorescence Anisotropy of the Cyanobacterial Circadian Clock
Methods and Protocols, 2019 Uniquely, the circadian clock of cyanobacteria can be reconstructed outside the complex milieu of live cells, greatly simplifying the investigation of a functioning biological chronometer. The core oscillator component is composed of only three proteins,
Joel Heisler +3 more
doaj +1 more source
Protein sequestration versus Hill-type repression in circadian clock models [PDF]
arXiv, 2016 Circadian (~24hr) clocks are self-sustained endogenous oscillators with which organisms keep track of daily and seasonal time. Circadian clocks frequently rely on interlocked transcriptional- translational feedback loops to generate rhythms that are robust against intrinsic and extrinsic perturbations.
arxiv
A core genetic module : the Mixed Feedback Loop [PDF]
, 2005 The so-called Mixed Feedback Loop (MFL) is a small two-gene network where protein A regulates the transcription of protein B and the two proteins form a heterodimer. It has been found to be statistically over-represented in statistical analyses of gene and protein interaction databases and to lie at the core of several computer-generated genetic ...
arxiv +1 more source
Branched chain amino acids, an ''essential'' link between diet, clock and sleep? [PDF]
arXiv, 2022 The branched-chain amino acids: leucine, isoleucine and valine occupy a special place among the essential amino acids because of their importance not only in the structure of proteins but also in general and cerebral metabolism. Among the first amino acids absorbed after food intake, they play a major role in the regulation of protein synthesis and ...
arxiv
Circadian clock proteins control adaptation to novel environment and memory formation
Aging, 2010 Deficiency of the transcription factor BMAL1, a core component of the circadian clock, results in an accelerated aging phenotype in mice. The circadian clock regulates many physiological processes and was recently implicated in control of brain-based ...
Anna A.Kondratova +3 more
semanticscholar +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Timed material self-assembly controlled by circadian clock proteins [PDF]
arXiv, 2023 Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation to materials. Because these systems can function robustly to regulate when and where chemical reactions occur, they have the ability to bring complex, life-like behavior to synthetic materials.
arxiv
Putative pacemakers of crayfish show clock proteins interlocked with circadian oscillations
Journal of Experimental Biology, 2010 SUMMARY Although the molecular mechanisms that control circadian rhythms in many animals, particularly in the fly, are well known, molecular and biochemical studies addressing the location and function of the proteins and genes contributing to the ...
E. Escamilla-Chimal +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source