Results 101 to 110 of about 127,418 (322)

The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription [PDF]

, 2014
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment ...
A Alboresi, A Ben-Shem, A Fukushima, A Kunihiro, A Pokhilko, A Pokhilko, B Al-Sady, B Berckmans, C Andronis, C Kami, CS Hardtke, D Alabadi, D Chen, DC Rockholm, E Huq, E Lopez-Juez, E Park, G Toledo-Ortiz, Gabriela Toledo-Ortiz, Gavin Steel, H Shen, H Shen, H Zhang, Henrik Johansson, J Foreman, J Lee, J Li, J Moon, J Shin, J Shin, J Shin, J Soy, J Sun, JA Stavang, JC del Pozo, JF Martinez-Garcia, JM Tepperman, Jordi Bou-Torrent, K Kobayashi, K Nozue, KA Franklin, KA Franklin, KA Franklin, Karen J. Halliday, Kelly Stewart, Keun Pyo Lee, KK Niyogi, Li-Jia Qu, M de Lucas, M Havaux, MA Koini, Manuel Rodríguez-Concepción, MC Proveniers, MF Covington, MH Walter, MT Osterlund, N Mochizuki, N Mochizuki, OS Lau, P Hornitschek, P Hornitschek, P Leivar, P Leivar, P Leivar, P Leivar, PG Stephenson, PH Quail, PH Quail, R Catala, R Henriques, R Welsch, S Chattopadhyay, S Ito, S Lorrain, S Makino, S Reinbothe, S Toh, SV Kumar, T Legnaioli, T Oyama, T Yamashino, T Yamashino, W Huang, Y Niwa, Y Nomoto, Y Nomoto, Y Zhang, Y Zhang, Y Zhang   +88 more
core   +5 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis. [PDF]

, 2018
Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by ...
Alexander, Walker, Dilbarova, Rima, Gilligan, John, Hoxha, Kevther, Kossenkov, Andrew, Mullin, James M., Prendergast, George C., Thomas, Sunil, Whittaker, Kelly   +8 more
core   +2 more sources

Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors

Tumor Biology, 2012
The majority of our genes may be regulated in a daily rhythm, including the genes for cell cycle control. Epidemiological and genetic evidences suggest that disruption of circadian timing mechanisms makes our cells more vulnerable to cancer formation.
Zsuzsanna, Lengyel, Csenge, Lovig, Siri, Kommedal, Rita, Keszthelyi, György, Szekeres, Zita, Battyáni, Valér, Csernus, András Dávid, Nagy   +7 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Somitogenesis Clock-Wave Initiation Requires Differential Decay and Multiple Binding Sites for Clock Protein

PLoS Computational Biology, 2010
Somitogenesis is a process common to all vertebrate embryos in which repeated blocks of cells arise from the presomitic mesoderm (PSM) to lay a foundational pattern for trunk and tail development. Somites form in the wake of passing waves of periodic gene expression that originate in the tailbud and sweep posteriorly across the PSM.
Mark Campanelli, Tomás Gedeon
openaire   +4 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.

, 2019
Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approaches and ...
Budak, H., Eichele, G., Oster, H., Petkau, N., Zhou, X.   +4 more
core   +1 more source

Light and circadian regulation of clock components aids flexible responses to environmental signals [PDF]

, 2014
The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops
Akman, Ozgur E, Dixon, Laura E, Hodge, Sarah K, Millar, Andrew J, Troein, Carl, van Ooijen, Gerben   +5 more
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source