Results 101 to 110 of about 125,163 (295)

Converting genetic network oscillations into somite spatial pattern

, 2007
In most vertebrate species, the body axis is generated by the formation of repeated transient structures called somites. This spatial periodicity in somitogenesis has been related to the temporally sustained oscillations in certain mRNAs and their ...
A. C. Oates, A. Sawada, B. Alberts, C. D. Stern, C. Freitas, C. M. Arizmendi, D. R. N. Primmett, D. R. N. Primmett, F. Giudicelli, F. Giudicelli, H. G. E. Hentschel, H. Meinhardt, K. I. Mazzitello, L. Glass, M. H. Glickman, M. K. Henry, O. Cinquin, O. Pourquié, S. A. Holley, U. Alon   +19 more
core   +1 more source

The HY5-PIF regulatory module coordinates light and temperature control of photosynthetic gene transcription [PDF]

, 2014
The ability to interpret daily and seasonal alterations in light and temperature signals is essential for plant survival. This is particularly important during seedling establishment when the phytochrome photoreceptors activate photosynthetic pigment ...
A Alboresi, A Ben-Shem, A Fukushima, A Kunihiro, A Pokhilko, A Pokhilko, B Al-Sady, B Berckmans, C Andronis, C Kami, CS Hardtke, D Alabadi, D Chen, DC Rockholm, E Huq, E Lopez-Juez, E Park, G Toledo-Ortiz, Gabriela Toledo-Ortiz, Gavin Steel, H Shen, H Shen, H Zhang, Henrik Johansson, J Foreman, J Lee, J Li, J Moon, J Shin, J Shin, J Shin, J Soy, J Sun, JA Stavang, JC del Pozo, JF Martinez-Garcia, JM Tepperman, Jordi Bou-Torrent, K Kobayashi, K Nozue, KA Franklin, KA Franklin, KA Franklin, Karen J. Halliday, Kelly Stewart, Keun Pyo Lee, KK Niyogi, Li-Jia Qu, M de Lucas, M Havaux, MA Koini, Manuel Rodríguez-Concepción, MC Proveniers, MF Covington, MH Walter, MT Osterlund, N Mochizuki, N Mochizuki, OS Lau, P Hornitschek, P Hornitschek, P Leivar, P Leivar, P Leivar, P Leivar, PG Stephenson, PH Quail, PH Quail, R Catala, R Henriques, R Welsch, S Chattopadhyay, S Ito, S Lorrain, S Makino, S Reinbothe, S Toh, SV Kumar, T Legnaioli, T Oyama, T Yamashino, T Yamashino, W Huang, Y Niwa, Y Nomoto, Y Nomoto, Y Zhang, Y Zhang, Y Zhang   +88 more
core   +5 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors [PDF]

, 2015
Skeletal muscle constitutes 40% of individual body mass and plays vital roles in locomotion and whole-body metabolism. Proteomics of skeletal muscle is challenging because of highly abundant contractile proteins that interfere with detection of ...
Cox, J., Deshmukh, A., Mann, M., Murgia, M., Nagaraj, N., Treebak, J.   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors

Tumor Biology, 2012
The majority of our genes may be regulated in a daily rhythm, including the genes for cell cycle control. Epidemiological and genetic evidences suggest that disruption of circadian timing mechanisms makes our cells more vulnerable to cancer formation.
Zsuzsanna, Lengyel, Csenge, Lovig, Siri, Kommedal, Rita, Keszthelyi, György, Szekeres, Zita, Battyáni, Valér, Csernus, András Dávid, Nagy   +7 more
openaire   +2 more sources

The role of inhibitory G proteins and regulators of G protein signaling in the in vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

, 2012
Inhibitory heterotrimeric G proteins and the control of heart rate. The activation of cell signaling pathways involving inhibitory heterotrimeric G proteins acts to slow the heart rate via modulation of ion channels.
Ang, R, Opel, A, Tinker, A
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Somitogenesis Clock-Wave Initiation Requires Differential Decay and Multiple Binding Sites for Clock Protein

PLoS Computational Biology, 2010
Somitogenesis is a process common to all vertebrate embryos in which repeated blocks of cells arise from the presomitic mesoderm (PSM) to lay a foundational pattern for trunk and tail development. Somites form in the wake of passing waves of periodic gene expression that originate in the tailbud and sweep posteriorly across the PSM.
Mark Campanelli, Tomás Gedeon
openaire   +4 more sources

ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis [PDF]

, 2018
Integration of environmental signals and interactions among photoreceptors and transcriptional regulators is key in shaping plant development. TANDEM ZINC-FINGER PLUS3 (TZP) is an integrator of light and photoperiodic signaling that promotes flowering in
Breton, Ghislain, Chory, Joanne, Davidson, Mhairi L.H., Herzyk, Pawel, Kaiserli, Eirini, Kay, Steve A., Nastase, Ana-Maria, O'Donnell, Liz, Perrella, Giorgio, Pruneda-Paz, Jose L.   +9 more
core   +1 more source