Results 141 to 150 of about 5,752,696 (345)
FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice
Cell Reports, 2017 Summary: The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense mutation in the flavin adenine dinucleotide (FAD) binding pocket of CRYPTOCHROME2 ...
Arisa Hirano +3 more
doaj
DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics
Nature CommunicationsThe vertebrate segmentation clock drives periodic somite segmentation during embryonic development. Her1 and Her7 clock proteins generate oscillatory expression of their own genes as well as that of deltaC in zebrafish. In turn, DeltaC and DeltaD ligands
Eslim Esra Alpay +4 more
doaj +1 more source
Biology Open, 2012 Summary Endogenous 24-hour rhythms are generated by circadian clocks located in most tissues. The molecular clock mechanism is based on feedback loops involving clock genes and their protein products.
Yaoming Yang +10 more
doaj +1 more source
Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation. [PDF]
Proc Natl Acad Sci U S A, 2023 Xie P +9 more
europepmc +1 more source
Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms [PDF]
, 2000 Manuel D Field +5 more
openalex +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
An evolutionary hotspot defines functional differences between CRYPTOCHROMES
Nature Communications, 2018 The molecular mechanisms that define the periodicity or rate of the circadian clock are not well understood. Here the authors use a multidisciplinary approach and identify a mechanism for period regulation that depends on the affinity of the core clock ...
Clark Rosensweig +7 more
doaj +1 more source
A role for the PERIOD:PERIOD homodimer in the Drosophila circadian clock.
PLoS Biology, 2009 Circadian clocks in eukaryotes rely on transcriptional feedback loops, in which clock genes repress their own transcription resulting in molecular oscillations with a period of approximately 24 h.
Johannes Landskron +3 more
doaj +1 more source
Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer. [PDF]
Biomedicines, 2021 Aroca-Siendones MI +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source