Results 151 to 160 of about 127,418 (322)

Regulation of Peripheral Molecular Clocks in Mammalian Tissues and In Vitro Skeletal Muscle Activation of AMP-Activated Protein Kinase via AICAR

, 2014
Most organisms possess a common molecular machinery that governs cellular and tissue circadian rhythmicity through a roughly 24-hour transcription-translation feedback loop.
Brandauer, Josef, Lupolt, Alex C., Moorhead, Daniel P.   +2 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The circadian clock protein REVERBα inhibits pulmonary fibrosis development [PDF]

, 2019
Peter S. Cunningham, P. J. J. De Meijer, Alicja Nazgiewicz, Simon Anderson, Lee A. Borthwick, James Bagnall, Gareth Kitchen, Monika Lodyga, Nicola Begley, R. Venkateswaran, Rajesh Shah, Paul F. Mercer, Hannah Durrington, Neil C. Henderson, Karen Piper Hanley, Andrew J. Fisher, Rachel C. Chambers, David A. Bechtold, Julie Gibbs, Andrew Loudon, Martin K. Rutter, Boris Hinz, David Ray, John Blaikley   +23 more
openalex   +3 more sources

Casein kinase 1 and disordered clock proteins form functionally equivalent, phospho-based circadian modules in fungi and mammals. [PDF]

Proc Natl Acad Sci U S A, 2022
Marzoll D, Serrano FE, Shostak A, Schunke C, Diernfellner ACR, Brunner M.   +5 more
europepmc   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Circadian Clock: A Regulator of Immunity in Autoimmune Diseases

Immunity, Inflammation and Disease
Aim Autoimmune diseases, characterized by the immune system mistakenly attacking the body's own tissues, are a growing global concern, with increasing prevalence.
Ye‐Jun Wu, Shu‐Ying Zhang, Hong‐Yu Chen, Xin‐Ran He, Guang‐Rui Yang   +4 more
doaj   +1 more source

Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms [PDF]

, 2011
Yongjin Lee, Rongmin Chen, Hyeong-Min Lee, Choogon Lee   +3 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Corrigendum: Low-Light Dependence of the Magnetic Field Effect on Cryptochromes: Possible Relevance to Plant Ecology

Frontiers in Plant Science, 2018
Jacques Vanderstraeten, Philippe Gailly, E. Pascal Malkemper, E. Pascal Malkemper   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source