Results 201 to 210 of about 5,752,696 (345)

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

ROS regulates circadian rhythms by modulating Ezh2 interactions with clock proteins. [PDF]

Redox Biol
Zhang HY, Li KY, Wang YL, Wei CJ, Gao YX, Ren-Zhou, Zhong YB, Yin ZJ, Ren DL.   +8 more
europepmc   +1 more source

Resetting the brain clock: time course and localization of mPER1 and mPER2 protein expression in suprachiasmatic nuclei during phase shifts [PDF]

, 2004
Lily Yan, Rae Silver
openalex   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

The APRR3 Component of the Clock-Associated APRR1/TOC1 Quintet is Phosphorylated by a Novel Protein Kinase Belonging to the WNK Family, the Gene for which is also Transcribed Rhythmically in Arabidopsis thaliana

, 2002
Masaya Murakami-Kojima, Norihito Nakamichi, Takafumi Yamashino, Takeshi Mizuno   +3 more
openalex   +1 more source

Protein Kinase G Type II Is Required for Night-to-Day Progression of the Mammalian Circadian Clock [PDF]

, 2004
Shelley A. Tischkau, Jennifer W. Mitchell, Laura Pace, Jessica W. Barnes, Jeffrey A. Barnes, Martha U. Gillette   +5 more
openalex   +1 more source

Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

Proceedings of the National Academy of Sciences of the United States of America, 2012
N. Kucera, Ira Schmalen, S. Hennig, R. Öllinger, H. Strauss, Astrid Grudziecki, Caroline Wieczorek, A. Kramer, E. Wolf   +8 more
semanticscholar   +1 more source

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Mutations in KaiA, a clock protein, extend the period of circadian rhythm in the cyanobacterium Synechococcus elongatus PCC 7942

, 2002
Hideya Nishimura, Keiko Imai, Hidehiko Saito, Makoto Hirai, Yoichi Nakahira, Hisayo Kondo, Hiroshi Hayashi, Takao Kondo, Akiko Tsuruhara   +8 more
openalex   +1 more source