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THE CROSSTALK BETWEEN PHYSIOLOGY AND CIRCADIAN CLOCK PROTEINS
Chronobiology International, 2009In mammals, many physiological processes present diurnal variations, and most of these rhythms persist even in absence of environmental timing cues. These endogenous circadian rhythms are generated by intracellular timing mechanisms termed circadian clocks.
David Duguay, Nicolas Cermakian
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Clock regulation of protein secretion
Nature Cell Biology, 2020The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.
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Holins: The Protein Clocks of Bacteriophage Infections
Annual Review of Microbiology, 2000▪ Abstract Two proteins, an endolysin and a holin, are essential for host lysis by bacteriophage. Endolysin is the term for muralytic enzymes that degrade the cell wall; endolysins accumulate in the cytosol fully folded during the vegetative cycle. Holins are small membrane proteins that accumulate in the membrane until, at a specific time that is ...
Ry Young, Ing-Nang Wang, David L. Smith
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Determining Divergence Times With Protein Clocks
The Biological Bulletin, 1999ported was a divergence time for prokaryotes and eukaryotes of only slightly more than two billion years ago. In line with this result, the average resemblance of these enzymes between Bacteria (a.k.a. eubacteria) and Eukarya (a.k.a. eukaryotes) was 37% identity.
Russell F. Doolittle +2 more
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Nucleic acid and protein clocks
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1991The use of pairwise comparisons of correctly aligned DNA and protein sequences for the measurement of time in historical biology remains a contentious matter. However, the limited success of some molecular evolutionary clocks provides a stimulus to attempt to improve their resolution by the judicious selection of sequences for ease of alignment ...
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Functional divergence of the circadian clock proteins in prokaryotes
Genetica, 2005Cyanobacteria are only prokaryotes known so far to have a circadian system. It may be based either on two (kaiB and kaiC) or three (kaiA, kaiB and kaiC) circadian genes. The homologs of two circadian proteins, KaiB and KaiC, form four major subfamilies (K1-K4) and also occur in some other prokaryotes. Using the likelihood-ratio tests, we studied a rate
Knudsen, B, Dvornyk, V
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A novel protein interacts with a clock-related protein, rPer1
Brain Research, 2001Mammalian Per proteins are thought to be important in the mechanism of circadian rhythm. We identified a novel protein PIPS (Per1 interacting protein of the suprachiasmatic nucleus) with the yeast two-hybrid system using PAS domain of rat Per1 (rPer1) as a bait.
Katsuya Nagai +4 more
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Chromatin Immunoprecipitation Protocol for Circadian Clock Proteins
2021Chromatin immunoprecipitation, or ChIP, is a powerful experimental technique for probing protein-DNA interactions in vivo. This assay can be used to investigate the association of a protein of interest with specific target loci. Alternatively, it can be combined with high-throughput sequencing technology to identify genome-wide binding sites.
Sally Adams, Isabelle A. Carré
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Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Science, 1998The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers. Potential partners of CLOCK were isolated in a two-hybrid screen, and one, BMAL1, was coexpressed with CLOCK and PER1 at known circadian clock sites in brain and retina ...
Fred C. Davis +21 more
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