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Correction: Nanomaterial-enabled drug delivery systems for circadian medicine: bridging direct rhythm modulation and chronotherapy. [PDF]
RSC AdvZeeshan M +7 more
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The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function. [PDF]
J Biol RhythmsSica V +9 more
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Clock regulation of protein secretion
Nature Cell Biology, 2020The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.
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Determining Divergence Times With Protein Clocks
The Biological Bulletin, 1999ported was a divergence time for prokaryotes and eukaryotes of only slightly more than two billion years ago. In line with this result, the average resemblance of these enzymes between Bacteria (a.k.a. eubacteria) and Eukarya (a.k.a. eukaryotes) was 37% identity.
R F, Doolittle, D F, Feng, G, Cho
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Chromatin Immunoprecipitation Protocol for Circadian Clock Proteins
2021Chromatin immunoprecipitation, or ChIP, is a powerful experimental technique for probing protein-DNA interactions in vivo. This assay can be used to investigate the association of a protein of interest with specific target loci. Alternatively, it can be combined with high-throughput sequencing technology to identify genome-wide binding sites.
Sally, Adams, Isabelle A, Carré
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Nucleic acid and protein clocks
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1991The use of pairwise comparisons of correctly aligned DNA and protein sequences for the measurement of time in historical biology remains a contentious matter. However, the limited success of some molecular evolutionary clocks provides a stimulus to attempt to improve their resolution by the judicious selection of sequences for ease of alignment ...
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Holins: The Protein Clocks of Bacteriophage Infections
Annual Review of Microbiology, 2000▪ Abstract Two proteins, an endolysin and a holin, are essential for host lysis by bacteriophage. Endolysin is the term for muralytic enzymes that degrade the cell wall; endolysins accumulate in the cytosol fully folded during the vegetative cycle. Holins are small membrane proteins that accumulate in the membrane until, at a specific time that is ...
I N, Wang, D L, Smith, R, Young
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Protein differences in tau mutant hamsters: candidate clock proteins
Molecular Brain Research, 1992In the tau mutant hamster, the period of the circadian rhythm is shortened from about 24 h to about 22 h in heterozygotes and to about 20 h in homozygotes. Understanding the biochemical basis of the period changes in the tau mutant may elucidate the regulation of the vertebrate pacemaker.
J E, Joy +6 more
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THE CROSSTALK BETWEEN PHYSIOLOGY AND CIRCADIAN CLOCK PROTEINS
Chronobiology International, 2009In mammals, many physiological processes present diurnal variations, and most of these rhythms persist even in absence of environmental timing cues. These endogenous circadian rhythms are generated by intracellular timing mechanisms termed circadian clocks.
David, Duguay, Nicolas, Cermakian
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Cell-permeable Circadian Clock Proteins
2002Abstract : Humans and most other organisms manifest circadian (daily) rhythms that are controlled by an endogenous biochemical oscillator. These 'biological clocks' are important to human physiology. For example, psychiatric and medical studies have shown that circadian rhythmicity is involved in some forms of depressive illness, 'jet lag', drug ...
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