Results 311 to 320 of about 5,752,696 (345)

PERK links the clock and protein stress in cancer

Nature Cell Biology, 2017
The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.
Miguel Sánchez-Álvarez, Chris Bakal
openaire   +2 more sources

Lifetimes of mRNAs for Clock‐Regulated Proteins in a Dinoflagellate

Chronobiology International, 2003
Both pulsed and continuous applications of the RNA polymerase II inhibitor thiolutin cause a dramatic but reversible loss of bioluminescence and its overt rhythmicity in cells of the dinoflagellate Lingulodinium polyedrum (formerly Gonyaulax polyedra). Such cells remain alive, and the rhythm resumes after an interval, the length of which depends on the
Carlos Rossini, Carlos Rossini, Walter Taylor, Thomas Fagan, J. Woodland Hastings   +4 more
openaire   +3 more sources

Circadian and photic regulation of clock and clock‐controlled proteins in the suprachiasmatic nuclei of calorie‐restricted mice

European Journal of Neuroscience, 2007
AbstractIn mammals, behavioural and physiological rhythms as well as clock gene expression in the central suprachiasmatic clock (SCN) are phase‐shifted by a timed calorie restriction (T‐CR; animals receiving at midday 66% of their daily food intake).
Mendoza, Jorge, Pévet, Paul, Challet, Etienne   +2 more
openaire   +7 more sources

PAS Proteins in the Mammalian Circadian Clock

2003
Many aspects of physiology are regulated in a temporal manner by an internal clock that anticipates the time of day and directs physiological processes accordingly (1). In mammals, cellular processes such as cholesterol and heme biosynthesis, temperature and hormonal rhythms, and the sleep wake cycle are all “timed” by the circadian clock to occur at ...
John B. Hogenesch, Steve A. Kay
openaire   +2 more sources

Cell-permeable Circadian Clock Proteins

2002
Abstract : Humans and most other organisms manifest circadian (daily) rhythms that are controlled by an endogenous biochemical oscillator. These 'biological clocks' are important to human physiology. For example, psychiatric and medical studies have shown that circadian rhythmicity is involved in some forms of depressive illness, 'jet lag', drug ...
openaire   +1 more source

Altered diurnal variation and localization of clock proteins in the remnant kidney of 5/6 nephrectomy rats

Nephrology, 2013
Xiao-mei Huang, Wen-Li Chen, Jing‐ping Yuan, Yue-hong Yang, Qi-Hui Mei, Li‐xia Huang   +5 more
semanticscholar   +1 more source

Light at Night Alters Daily Patterns of Cortisol and Clock Proteins in Female Siberian Hamsters

Journal of neuroendocrinology, 2013
T. Bedrosian, Anabel Galan, C. Vaughn, Z. Weil, Randy J. Nelson   +4 more
semanticscholar   +1 more source

Circadian clock of cyanobacteria: Expression of kaiABC and function of Kai clock proteins

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 1999
Masahiro Ishiura, Takao Kondo
openaire   +2 more sources

Multiple signals regulate the cellular localization of the circadian clock protein CLOCK

GBM Annual Spring meeting Mosbach 2007, 2007
Frank Weber, Natalie Mena, Christian Maurer, Tatjana Wüst   +3 more
openaire   +2 more sources

Nanooncology: The future of cancer diagnosis and therapy

Ca-A Cancer Journal for Clinicians, 2013
Avnesh S Thakor
exaly