Recent advances in modulators of circadian rhythms: an update and perspective
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna.
Shenzhen Huang +5 more
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Accurate timekeeping is controlled by a cycling activator in Arabidopsis. [PDF]
, 2013 Transcriptional feedback loops are key to circadian clock function in many organisms. Current models of the Arabidopsis circadian network consist of several coupled feedback loops composed almost exclusively of transcriptional repressors.
Devisetty, Upendra K +2 more
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Circadian clocks and breast cancer [PDF]
, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
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CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells
Experimental and Molecular Medicine, 2018 Cancer: Clocking the triggers for tumor progression Two proteins involved in regulating circadian rhythms may promote cancer tumor growth by changing the internal structures of cells.
Teng-jiao Ma +6 more
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Clock is important for food and circadian regulation of macronutrient absorption in mice
Journal of Lipid Research, 2009 Clock genes respond to external stimuli and exhibit circadian rhythms. This study investigated the expression of clock genes in the small intestine and their contribution in the regulation of nutrient absorption by enterocytes.
Xiaoyue Pan, M. Mahmood Hussain
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Heterogeneous expression of the core circadian clock proteins among neuronal cell types in mouse retina. [PDF]
PLoS ONE, 2012 Circadian rhythms in metabolism, physiology, and behavior originate from cell-autonomous circadian clocks located in many organs and structures throughout the body and that share a common molecular mechanism based on the clock genes and their protein ...
Xiaoqin Liu +2 more
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Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
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Circadian rhythms and post-transcriptional regulation in higher plants [PDF]
, 2015 The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés +1 more
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Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration [PDF]
, 2013 Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism.
Adam Q. Bauer +25 more
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Rate variation during molecular evolution: creationism and the cytochrome c molecular clock [PDF]
, 2017 Molecular clocks based upon amino acid sequences in proteins have played a major role in the clarification of evolutionary phylogenies. Creationist criticisms of these methods sometimes rely upon data that might initially seem to be paradoxical.
Hofmann James, R.
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