Results 41 to 50 of about 5,752,696 (345)

ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer

Frontiers in Oncology, 2020
ObjectiveTriple-negative (PR−, ER−, HER-2−) breast cancer (TNBC) is regarded as more aggressive and more likely to recur after medical care. Emerging evidence has demonstrated that the circadian clock system regulates cell-signaling pathways critical to ...
FenFen Xie, FenFen Xie, FenFen Xie, FenFen Xie, FenFen Xie, FenFen Xie, LiLi Wang, YaJing Liu, YaJing Liu, YaJing Liu, YaJing Liu, YaJing Liu, ZhenBang Liu, ZuoYang Zhang, Jing Pei, ZhengSheng Wu, MuXin Zhai, YunXia Cao, YunXia Cao, YunXia Cao, YunXia Cao, YunXia Cao   +21 more
doaj   +1 more source

Transcriptional Feedback Loops in the Caprine Circadian Clock System

Frontiers in Veterinary Science, 2022
The circadian clock system is based on interlocked positive and negative transcriptional and translational feedback loops of core clock genes and their encoded proteins.
Dengke Gao, Dengke Gao, Hongcong Zhao, Hongcong Zhao, Hao Dong, Hao Dong, Yating Li, Yating Li, Jing Zhang, Jing Zhang, Haisen Zhang, Haisen Zhang, Yu Zhang, Yu Zhang, Haizhen Jiang, Haizhen Jiang, Xiaoyu Wang, Xiaoyu Wang, Aihua Wang, Aihua Wang, Yaping Jin, Yaping Jin, Huatao Chen, Huatao Chen   +23 more
doaj   +1 more source

Low-Light Dependence of the Magnetic Field Effect on Cryptochromes: Possible Relevance to Plant Ecology

Frontiers in Plant Science, 2018
Various responses to static magnetic fields (MF) have been reported in plants, and it has been suggested that the geomagnetic field influences plant physiology. Accordingly, diverse mechanisms have been proposed to mediate MF effects in plants.
Jacques Vanderstraeten, Philippe Gailly, E. Pascal Malkemper, E. Pascal Malkemper   +3 more
doaj   +1 more source

Characterizing the circadian connectome of Ocimum tenuiflorum using an integrated network theoretic framework

Scientific Reports, 2023
Across the three domains of life, circadian clock is known to regulate vital physiological processes, like, growth, development, defence etc. by anticipating environmental cues.
Vikram Singh, Vikram Singh
doaj   +1 more source

Stabilizing daily clock proteins [PDF]

Biochemical Journal, 2006
Biological timekeeping is determined by internal temporal programmes and the resetting of these programmes or clocks by external stimuli. Many of the core genes of the mammalian daily or circadian clock are known, but the factors regulating so-called ‘clock’ gene proteins are unclear.
openaire   +4 more sources

Chronic inhibition of endoplasmic reticulum calcium-release channels and calcium-ATPase lengthens the period of hepatic clock gene Per1

Journal of Circadian Rhythms, 2011
Background The role played by calcium as a regulator of circadian rhythms is not well understood. The effect of the pharmacological inhibition of the ryanodine receptor (RyR), inositol 1,4,5-trisphosphate receptor (IP3R), and endoplasmic-reticulum Ca2 ...
Díaz-Muñoz Mauricio, Báez-Ruiz Adrián   +1 more
doaj   +1 more source

Circadian Clock Protein Content and Daily Rhythm of Locomotor Activity Are Altered after Chronic Exposure to Lead in Rat

Frontiers in Behavioral Neuroscience, 2017
Lead exposure has been reported to produce many clinical features, including parkinsonism. However, its consequences on the circadian rhythms are still unknown.
Mariam Sabbar, Ouria Dkhissi-Benyahya, Abdelhamid Benazzouz, Abdelhamid Benazzouz, Nouria Lakhdar-Ghazal   +4 more
doaj   +1 more source

Proteome analysis of the circadian clock protein PERIOD2

Proteins: Structure, Function, and Bioinformatics, 2022
AbstractCircadian rhythms are a series of endogenous autonomous 24‐h oscillations generated by the circadian clock. At the molecular level, the circadian clock is based on a transcription–translation feedback loop, in which BMAL1 and CLOCK transcription factors of the positive arm activate the expression of CRYPTOCHROME (CRY) and PERIOD (PER) genes of ...
Huseyin Gul, Saba Selvi, Fatma Yilmaz, Gozde Ozcelik, Senanur Olfaz‐Aslan, Seyma Yazan, Busra Tiryaki, Seref Gul, Ali Yurtseven, Ibrahim Halil Kavakli, Nurhan Ozlu, Nuri Ozturk   +11 more
openaire   +3 more sources

Influences of desflurane on the central and hepatic circadian clock persist at 24 hours following anaesthesia in rats [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Circadian rhythm disturbances caused by anaesthesia may be one of the important reasons of many disturbances following surgery. The effects of 6% desflurane on suprachiasmatic nucleus (SCN), liver, and pancreas PER2, CRY1, BMAL, and CLOCK circadian ...
Ilknur Hatice AKBUDAK, Ozgen KILIC-ERKEK, Melek BOR-KUCUKATAY   +2 more
doaj   +1 more source

Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map [PDF]

Computational Biology and Chemistry, 2006
Vertebrate segmentation has been proved to be under a strict temporal control governed by a biological clock, known as the segmentation clock. The present experimental evidence suggests that the segmentation clock initiates and maintains its periodic cycle by the periodic activation or inhibition of the Notch signaling pathway as well as the periodic ...
Predrag Radivojac, Sourav Roy, Santiago Schnell   +2 more
openaire   +3 more sources