Results 41 to 50 of about 125,163 (295)
Clock proteins: Turned over after hours? [PDF]
Current Biology, 2000 Light sensitivity and the involvement of unstable proteins are key features of circadian clocks. Both photoreception and ubiquitin conjugation may be associated with nuclear regulators encoded by genes recently identified in Arabidopsis.
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Distinct roles of DBHS family members in the circadian transcriptional feedback loop [PDF]
, 2012 Factors interacting with core circadian clock components are essential to achieve transcriptional feedback necessary for metazoan clocks. Here we show that all three members of the Drosophila Behavior Human Splicing (DBHS) family of RNA-binding proteins ...
Brown, Steven A. +7 more
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Journal of Circadian Rhythms, 2011 Background The role played by calcium as a regulator of circadian rhythms is not well understood. The effect of the pharmacological inhibition of the ryanodine receptor (RyR), inositol 1,4,5-trisphosphate receptor (IP3R), and endoplasmic-reticulum Ca2 ...
Díaz-Muñoz Mauricio +1 more
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Parallel analysis of Arabidopsis circadian clock mutants reveals different scales of transcriptome and proteome regulation [PDF]
Open Biology, 2017 The circadian clock regulates physiological processes central to growth and survival. To date, most plant circadian clock studies have relied on diurnal transcriptome changes to elucidate molecular connections between the circadian clock and observable ...
Alexander Graf +6 more
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Protein interaction networks of the mammalian core clock proteins
, 2022 Circadian rhythm is a 24-h cycle that regulates the biochemical and behavioral changes of organisms. It controls a wide range of functions, from gene expression to behavior, allowing organisms to anticipate daily changes in their environment. In mammals, circadian rhythm is generated by a complex transcriptional and translational feedback loop ...
Kavakli, Ibrahim Halil +2 more
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Circadian clock protein Rev-erbα regulates neuroinflammation [PDF]
Proceedings of the National Academy of Sciences, 2019 Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with neuroinflammation. Circadian rhythm dysfunction has been associated with inflammation in the periphery, but the role of the core clock in neuroinflammation remains poorly understood. Here we demonstrate that Rev-erbα, a nuclear
Percy Griffin +14 more
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Frontiers in Behavioral Neuroscience, 2017 Lead exposure has been reported to produce many clinical features, including parkinsonism. However, its consequences on the circadian rhythms are still unknown.
Mariam Sabbar +4 more
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Nucleocytoplasmic Shuttling of Clock Proteins
, 2005 The mammalian circadian clock in the neurons of suprachiasmatic nuclei (SCN) in the brain and in cells of peripheral tissues is driven by a self-sustained molecular oscillator, which generates rhythmic gene expression with a periodicity of about 24?h (Reppert and Weaver, 2002).
Tamanini, Filippo +3 more
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Molecular clock in neutral protein evolution [PDF]
BMC Genetics, 2004 Abstract Background A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean) substantially larger than one. This observation has been termed the overdispersed molecular clock.
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Influences of desflurane on the central and hepatic circadian clock persist at 24 hours following anaesthesia in rats [PDF]
Kafkas Universitesi Veteriner Fakültesi DergisiCircadian rhythm disturbances caused by anaesthesia may be one of the important reasons of many disturbances following surgery. The effects of 6% desflurane on suprachiasmatic nucleus (SCN), liver, and pancreas PER2, CRY1, BMAL, and CLOCK circadian ...
Ilknur Hatice AKBUDAK +2 more
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