Results 51 to 60 of about 5,752,696 (345)
Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
Genes & Development, 2021 In all organisms with circadian clocks, post-translational modifications of clock proteins control the dynamics of circadian rhythms, with phosphorylation playing a dominant role. All major clock proteins are highly phosphorylated, and many kinases have been described to be responsible.
Sabrina Klemz +11 more
openaire +4 more sources
Recent advances in modulators of circadian rhythms: an update and perspective
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna.
Shenzhen Huang +5 more
doaj +1 more source
Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance The molecular circadian clock regulates daily rhythms in gene expression, cellular function, and animal behavior. Clock proteins can also regulate noncircadian functions that are highly cell-type specific.
Celia A. McKee +3 more
semanticscholar +1 more source
CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells
Experimental and Molecular Medicine, 2018 Cancer: Clocking the triggers for tumor progression Two proteins involved in regulating circadian rhythms may promote cancer tumor growth by changing the internal structures of cells.
Teng-jiao Ma +6 more
doaj +1 more source
Thermodynamics of Neutral Protein Evolution [PDF]
Genetics 175:1-12 (January 2007), 2006 Naturally evolving proteins gradually accumulate mutations while continuing to fold to thermodynamically stable native structures. This process of neutral protein evolution is an important mode of genetic change, and forms the basis for the molecular clock.
arxiv +1 more source
The Molecular Clock in the Evolution of Protein Structures
Systematic Biology, 2019 AbstractThe molecular clock hypothesis, which states that substitutions accumulate in protein sequences at a constant rate, plays a fundamental role in molecular evolution but it is violated when selective or mutational processes vary with time. Such violations of the molecular clock have been widely investigated for protein sequences, but not yet for ...
Ugo Bastolla +5 more
openaire +5 more sources
Parallel analysis of Arabidopsis circadian clock mutants reveals different scales of transcriptome and proteome regulation [PDF]
Open Biology, 2017 The circadian clock regulates physiological processes central to growth and survival. To date, most plant circadian clock studies have relied on diurnal transcriptome changes to elucidate molecular connections between the circadian clock and observable ...
Alexander Graf +6 more
doaj +1 more source
Cost and Precision of Brownian Clocks [PDF]
Phys. Rev. X 6, 041053 (2016), 2016 Brownian clocks are biomolecular networks that can count time. A paradigmatic example are proteins that go through a cycle thus regulating some oscillatory behaviour in a living system. Typically, such a cycle requires free energy often provided by ATP hydrolysis.
arxiv +1 more source
Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals. [PDF]
PLoS ONE, 2008 In mammals, the circadian clock relies on interlocked feedback loops involving clock genes and their protein products. Post-translational modifications control intracellular trafficking, functionality and degradation of clock proteins and are keys to the
Hugues Dardente +4 more
doaj +1 more source
Waveforms of molecular oscillations reveal circadian timekeeping mechanisms [PDF]
Commun. Biol. 1, 207 (2018), 2018 Circadian clocks play a pivotal role in orchestrating numerous physiological and developmental events. Waveform shapes of the oscillations of protein abundances can be informative about the underlying biochemical processes of circadian clocks. We derive a mathematical framework where waveforms do reveal hidden biochemical mechanisms of circadian ...
arxiv +1 more source