Results 51 to 60 of about 127,418 (322)
Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals. [PDF]
PLoS ONE, 2008 In mammals, the circadian clock relies on interlocked feedback loops involving clock genes and their protein products. Post-translational modifications control intracellular trafficking, functionality and degradation of clock proteins and are keys to the
Hugues Dardente +4 more
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Distinct roles of DBHS family members in the circadian transcriptional feedback loop [PDF]
, 2012 Factors interacting with core circadian clock components are essential to achieve transcriptional feedback necessary for metazoan clocks. Here we show that all three members of the Drosophila Behavior Human Splicing (DBHS) family of RNA-binding proteins ...
Brown, Steven A. +7 more
core +1 more source
Nucleocytoplasmic Shuttling of Clock Proteins
, 2005 The mammalian circadian clock in the neurons of suprachiasmatic nuclei (SCN) in the brain and in cells of peripheral tissues is driven by a self-sustained molecular oscillator, which generates rhythmic gene expression with a periodicity of about 24?h (Reppert and Weaver, 2002).
Tamanini, Filippo +3 more
openaire +3 more sources
Molecular clock in neutral protein evolution [PDF]
BMC Genetics, 2004 Abstract Background A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean) substantially larger than one. This observation has been termed the overdispersed molecular clock.
openaire +4 more sources
Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. [PDF]
, 2017 Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Atger, F. +14 more
core +1 more source
Inverse relationship between genetic diversity and epigenetic complexity [PDF]
, 2008 Early studies of molecular evolution revealed a correlation between genetic distance and time of species divergence. This observation provoked the molecular clock hypothesis and in turn the ‘Neutral Theory’, which however remains an ...
Shi Huang
core +3 more sources
Analysis of DNA-Damage Response to ionizing radiation in serum-shock synchronized human fibroblasts. [PDF]
, 2017 Many aspects of cellular physiology, including cellular response to genotoxic stress, are related to the circadian rhythmicity induced by the molecular clock.
Barbieri, Vito +4 more
core +1 more source
Frontiers in Molecular Neuroscience, 2018 Endogenous molecular circadian clocks drive daily rhythmic changes at the cellular, physiological, and behavioral level for adaptation to and anticipation of environmental signals.
Katherina Beck +4 more
doaj +1 more source
Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. [PDF]
PLoS ONE, 2012 Spermatogenesis is a complex differentiation process that involves genetic and epigenetic regulation, sophisticated hormonal control, and extensive structural changes in male germ cells.
Rita L Peruquetti +2 more
doaj +1 more source
Direct regulation of CLOCK expression by REV-ERB. [PDF]
PLoS ONE, 2011 Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY).
Christine Crumbley, Thomas P Burris
doaj +1 more source