Results 71 to 80 of about 125,163 (295)

FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice

Cell Reports, 2017
Summary: The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense mutation in the flavin adenine dinucleotide (FAD) binding pocket of CRYPTOCHROME2 ...
Arisa Hirano, Daniel Braas, Ying-Hui Fu, Louis J. Ptáček   +3 more
doaj   +1 more source

Solving the mystery of human sleep schedules one mutation at a time. [PDF]

, 2013
Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui, Hallows, William C, Ptáček, Louis J   +2 more
core   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals.  Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo   +2 more
doaj   +1 more source

Acute hypoxia induced dysregulation of clock-controlled ovary functions

Frontiers in Physiology, 2022
High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental stimuli ...
Mengnan Ding, Yarong Lu, Yarong Lu, Xin Huang, Chen Xing, Shaojun Hou, Shaojun Hou, Shaojun Hou, Dongxue Wang, Dongxue Wang, Yifan Zhang, Wei Wang, Wei Wang, Chongchong Zhang, Chongchong Zhang, Min Zhang, Min Zhang, Fanfei Meng, Kun Liu, Guangchao Liu, Jincheng Zhao, Lun Song, Lun Song, Lun Song, Lun Song   +24 more
doaj   +1 more source

Analysis of DNA-Damage Response to ionizing radiation in serum-shock synchronized human fibroblasts. [PDF]

, 2017
Many aspects of cellular physiology, including cellular response to genotoxic stress, are related to the circadian rhythmicity induced by the molecular clock.
Barbieri, Vito, Bee, Leonardo, Corra', Samantha, Mognato, Maddalena, Salvadori, Riccardo   +4 more
core   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Correlation between circadian and photoperiodic latitudinal clines in Drosophila littoralis

Open Biology
Insects can survive harsh conditions, including Arctic winters, by entering a hormonally induced state of dormancy, known as diapause. Diapause is triggered by environmental cues such as shortening of the photoperiod (lengthening of the night).
Giulia Manoli, Pekka Lankinen, Enrico Bertolini, Charlotte Helfrich-Förster   +3 more
doaj   +1 more source

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals.  Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo   +2 more
doaj   +1 more source

PSMD11 modulates circadian clock function through PER and CRY nuclear translocation.

PLoS ONE, 2023
The molecular circadian clock is regulated by a transcriptional translational feedback loop. However, the post-translational control mechanisms are less understood. The NRON complex is a large ribonucleoprotein complex, consisting of a lncRNA and several
Sibel Cal-Kayitmazbatir, Lauren J Francey, Yool Lee, Andrew C Liu, John B Hogenesch   +4 more
doaj   +1 more source