Results 81 to 90 of about 5,752,696 (345)

Acute hypoxia induced dysregulation of clock-controlled ovary functions

Frontiers in Physiology, 2022
High altitudes or exposure to hypoxia leads to female reproductive disorders. Circadian clocks are intrinsic time-tracking systems that enable organisms to adapt to the Earth’s 24-h light/dark cycle, which can be entrained by other environmental stimuli ...
Mengnan Ding, Yarong Lu, Yarong Lu, Xin Huang, Chen Xing, Shaojun Hou, Shaojun Hou, Shaojun Hou, Dongxue Wang, Dongxue Wang, Yifan Zhang, Wei Wang, Wei Wang, Chongchong Zhang, Chongchong Zhang, Min Zhang, Min Zhang, Fanfei Meng, Kun Liu, Guangchao Liu, Jincheng Zhao, Lun Song, Lun Song, Lun Song, Lun Song   +24 more
doaj   +1 more source

Complementary approaches to understanding the plant circadian clock [PDF]

EPTCS 19, 2010, pp. 1-19, 2010
Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system facilitate the testing of computational predictions. We present a model of the Ostreococcus clock in the
arxiv   +1 more source

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals.  Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo   +2 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Repressor dimerization in the zebrafish somitogenesis clock. [PDF]

PLoS Computational Biology, 2007
The oscillations of the somitogenesis clock are linked to the fundamental process of vertebrate embryo segmentation, yet little is known about their generation.
Olivier Cinquin
doaj   +1 more source

Stoichiometric Relationship among Clock Proteins Determines Robustness of Circadian Rhythms*

Journal of Biological Chemistry, 2011
The mammalian circadian oscillator is primarily driven by an essential negative feedback loop comprising a positive component, the CLOCK-BMAL1 complex, and a negative component, the PER-CRY complex.
Yongjin Lee, Rongmin Chen, Hyeong-min Lee, Choogon Lee   +3 more
semanticscholar   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals.  Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo   +2 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Cross-scale analysis of temperature compensation in the cyanobacterial circadian clock system

Communications Physics, 2022
The mechanism by which circadian clock proteins compensate for changes in temperature to maintain regular operation remains unclear. Here, temperature compensation from the reaction to cell level is explained by large-scale motions inside the clock ...
Yoshihiko Furuike, Dongyan Ouyang, Taiki Tominaga, Tatsuhito Matsuo, Atsushi Mukaiyama, Yukinobu Kawakita, Satoru Fujiwara, Shuji Akiyama   +7 more
doaj   +1 more source