Results 111 to 120 of about 2,119,256 (322)

Altered Repertoire Diversity and Disease‐Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients [PDF]

, 2020
Aimee Hanson, Hendrik J. Nel, Linda A. Bradbury, Julie Phipps, Ranjeny Thomas, Kim‐Anh Lê Cao, Tony Kenna, Matthew A. Brown   +7 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Impact of Splicing Factor Mutations on Clonal Hematopoiesis and Myeloid Neoplasm Progression

Frontiers in Bioscience-Landmark
Clonal hematopoiesis (CH) is characterized by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations, which confers an increased risk of hematologic malignancies and cardiovascular disease.
Takuya Izumi-Tamura, Asuka Kawachi, Akihide Yoshimi   +2 more
doaj   +1 more source

Limiting Dilution & Clonal Expansion v1 [PDF]

, 2018
CRISPR-Cas9 can be used to generate edited cell pools for a variety of applications. These pools contain a heterogeneous mix of cells, some unedited and some with different genetic alterations at the targeted locus. In order to produce a cell line with a particular edit or knockout, clonal expansion of individual cells is necessary.
openaire   +1 more source

Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients

Nature Cancer, 2021
L. Biasco, N. Izotova, C. Rivat, S. Ghorashian, R. Richardson, A. Guvenel, R. Hough, R. Wynn, B. Popova, Andre Lopes, M. Pule, A. Thrasher, P. Amrolia   +12 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Long-term remission despite clonal expansion of replication-competent HIV-1 isolates.

JCI Insight, 2018
Clonal expansion of T cells harboring replication-competent virus has recently been demonstrated in patients on suppressive antiretroviral therapy (ART) regimens.
R. Veenhuis, Abena K. Kwaa, Caroline C. Garliss, R. Latanich, M. Salgado, C. Pohlmeyer, Christopher L. Nobles, J. Gregg, E. Scully, J. Bailey, F. Bushman, J. Blankson   +11 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Clones in blood and stratified epithelial cells, and their drivers

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
The term “clone” is commonly used in the medical and life sciences to denote a genetically identical population, at both the individual and cellular levels. The concept of clonal expansion is of fundamental importance in cancer research.
Shigeru CHIBA
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source