Multiplex gene editing models of del(7q) reveal combined <i>CUX1</i> and <i>EZH2</i> loss drives clonal expansion and drug resistance. [PDF]
Jotte MRM +13 more
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Publisher Correction: TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation. [PDF]
Nutsch K +12 more
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Isoeugenol Inhibits Adipogenesis in 3T3-L1 Preadipocytes with Impaired Mitotic Clonal Expansion. [PDF]
Choi YR, Na HJ, Lee J, Kim YS, Kim MJ.
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CarcSeq detection of lorcaserin-induced clonal expansion of Pik3ca H1047R mutants in rat mammary tissue. [PDF]
Faske JB +6 more
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Immune checkpoint therapy responders display early clonal expansion of tumor infiltrating lymphocytes. [PDF]
Kidman J +21 more
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TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation. [PDF]
Nutsch K +12 more
europepmc +1 more source
Spontaneous high clonal expansion of Wilms' tumor gene 1-specific cytotoxic T-lymphocytes in patients with Wilms' tumor gene 1-expressing solid tumor. [PDF]
Morimoto S +20 more
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Clonal expansion in non-cancer tissues
Nature Reviews Cancer, 2021Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are positively selected by acquisition of 'driver mutations'. However, the evolution of positively selected clones does not necessarily imply the presence of cancer.
Nobuyuki Kakiuchi, Seishi Ogawa
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Clonal expansion of innate and adaptive lymphocytes
Nature Reviews Immunology, 2020One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of individual cell clones that encounter their cognate antigen. More recently, however, there is growing evidence for the clonal expansion of innate lymphocytes, particularly in the context of pathogen challenge.
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