Results 31 to 40 of about 2,119,256 (322)

Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs. [PDF]

PLoS Genetics, 2018
Postzygotic single-nucleotide mosaicisms (pSNMs) have been extensively studied in tumors and are known to play critical roles in tumorigenesis. However, the patterns and origin of pSNMs in normal organs of healthy humans remain largely unknown.
August Yue Huang, Xiaoxu Yang, Sheng Wang, Xianing Zheng, Qixi Wu, Adam Yongxin Ye, Liping Wei   +6 more
doaj   +1 more source

mRNA COVID-19 vaccine elicits potent adaptive immune response without the acute inflammation of SARS-CoV-2 infection

iScience, 2023
Summary: SARS-CoV-2 infection and vaccination elicit potent immune responses. Our study presents a comprehensive multimodal single-cell analysis of blood from COVID-19 patients and healthy volunteers receiving the SARS-CoV-2 vaccine and booster.
Ellie N. Ivanova, Jasmine Shwetar, Joseph C. Devlin, Terkild B. Buus, Sophie Gray-Gaillard, Akiko Koide, Amber Cornelius, Marie I. Samanovic, Alberto Herrera, Eleni P. Mimitou, Chenzhen Zhang, Trishala Karmacharya, Ludovic Desvignes, Niels Ødum, Peter Smibert, Robert J. Ulrich, Mark J. Mulligan, Shohei Koide, Kelly V. Ruggles, Ramin S. Herati, Sergei B. Koralov   +20 more
doaj   +1 more source

Many colorectal cancers are “flat” clonal expansions [PDF]

Cell Cycle, 2009
Population geneticists can reconstruct the ancestries of macroscopic populations from polymorphisms in present day individuals. For example, the migration "out of Africa" is recorded in human genome variation in different parts of the world. Here we apply this approach to human colorectal cancer cell populations and polymorphic passenger methylation ...
Kimberly D, Siegmund, Paul, Marjoram, Simon, Tavaré, Darryl, Shibata   +3 more
openaire   +2 more sources

Effects of Cu Pollution on the Expansion of an Amphibious Clonal Herb in Aquatic-Terrestrial Ecotones. [PDF]

PLoS ONE, 2016
Physiological integration can enhance the performance of clonal plants in aquatic and terrestrial heterogeneous habitats and associated ecotones. Similar to nutrients, pollutants may be transported among connected ramets via physiological integration ...
Liang Xu, Zhen-Feng Zhou
doaj   +1 more source

Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)

Experimental Hematology & Oncology, 2019
Background Large clonal populations of cells bearing PIG-A mutations are the sine qua non of PNH, but the PIG-A mutation itself is insufficient for clonal expansion.
Camille Lobry, Ashish Bains, Leah B. Zamechek, Sherif Ibrahim, Iannis Aifantis, David J. Araten   +5 more
doaj   +1 more source

Computational identification of clonal cells in single-cell CRISPR screens

BMC Genomics, 2022
Background Single-cell CRISPR screens are powerful tools to understand genome function by linking genetic perturbations to transcriptome-wide phenotypes.
Yihan Wang, Shiqi Xie, Daniel Armendariz, Gary C. Hon   +3 more
doaj   +1 more source

Bayesian Inference of Clonal Expansions in a Dated Phylogeny [PDF]

Systematic Biology, 2021
Abstract Microbial population genetics models often assume that all lineages are constrained by the same population size dynamics over time. However, many neutral and selective events can invalidate this assumption and can contribute to the clonal expansion of a specific lineage relative to the rest of the population.
David Helekal, Alice Ledda, Erik Volz, David Wyllie, Xavier Didelot   +4 more
openaire   +3 more sources

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Nature Communications, 2018
Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
Terrence N. Wong, Christopher A. Miller, Matthew R. M. Jotte, Nusayba Bagegni, Jack D. Baty, Amy P. Schmidt, Amanda F. Cashen, Eric J. Duncavage, Nichole M. Helton, Mark Fiala, Robert S. Fulton, Sharon E. Heath, Megan Janke, Kierstin Luber, Peter Westervelt, Ravi Vij, John F. DiPersio, John S. Welch, Timothy A. Graubert, Matthew J. Walter, Timothy J. Ley, Daniel C. Link   +21 more
doaj   +1 more source

RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

Science, 2019
Somatic mosaicism in normal tissues Somatic cells can accumulate mutations over the course of an individual's lifetime. This generates cells that differ genetically at specific loci within the genome.
Keren Yizhak, F. Aguet, Jaegil Kim, J. Hess, Kirsten Kübler, J. Grimsby, Ruslana Frazer, Hailei Zhang, N. Haradhvala, D. Rosebrock, D. Livitz, Xiao Li, Eila Arich-Landkof, N. Shoresh, C. Stewart, A. Segrè, P. Branton, P. Polak, K. Ardlie, G. Getz   +19 more
semanticscholar   +1 more source

Developmentally Programmed Division of Labor in the Aquatic Invader Alternanthera philoxeroides Under Homogeneous Soil Nutrients

Frontiers in Plant Science, 2019
Clonal traits can contribute to plant invasiveness, but little is known about the roles of division of labor (a key clonal trait) in homogeneous habitats. The hypothesis tested is that clonal integration allows division of labor and increases the overall
Dao-Guo Xi, Wen-Hua You, An-An Hu, Ping Huang, Dao-Lin Du   +4 more
doaj   +1 more source