Results 31 to 40 of about 95,784 (161)
FTO influences adipogenesis by regulating mitotic clonal expansion [PDF]
Nature Communications, 2015 AbstractThe fat mass and obesity-associated (FTO) gene plays a pivotal role in regulating body weight and fat mass; however, the underlying mechanisms are poorly understood. Here we show that primary adipocytes and mouse embryonic fibroblasts (MEFs) derived from FTO overexpression (FTO-4) mice exhibit increased potential for adipogenic differentiation,
Merkestein, Myrte +10 more
openaire +3 more sources
Viruses, 2021 More than 50% of the HIV-1 latent reservoir is maintained by clonal expansion. The clonally expanded HIV-1-infected cells can contribute to persistent nonsuppressible low-level viremia and viral rebound.
Yang-Hui Jimmy Yeh +3 more
doaj +1 more source
The rise and rise of mitochondrial DNA mutations [PDF]
Open Biology, 2020 How mitochondrial DNA mutations clonally expand in an individual cell is a question that has perplexed mitochondrial biologists for decades. A growing body of literature indicates that mitochondrial DNA mutations play a major role in ageing, metabolic ...
Conor Lawless +4 more
doaj +1 more source
Clonal expansion of T-cells in measles
Immunology Letters, 1998 Some autoimmune complications such as postinfectious encephalomyelitis are associated with immunologic abnormalities induced by measles virus infection. To address the superantigenic stimulation in measles which might be related with autoimmune complications, T-cells bearing the TCRBV5S2 or TCRBV8 chains and the expression of activation markers were ...
Chwae, YJ +6 more
openaire +3 more sources
Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria
Frontiers in Immunology, 2022 Paroxysmal Nocturnal Hemoglobinuria (PNH) is a disease as simple as it is complex. PNH patients develop somatic loss-of-function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene (PIGA), required for the biosynthesis of ...
Melissa A. Colden +7 more
doaj +1 more source
Clonal Expansion of Verticillium dahliae in Lettuce [PDF]
Phytopathology®, 2014 Few studies in population biology have documented how structure and diversity of pathogens evolve over time at local scales. With the historical samples of Verticillium dahliae available from lettuce, we investigated the structure and diversity of this pathogen in time and space. Three hundred twenty-nine V.
S, Gurung +3 more
openaire +2 more sources
Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
Nature Communications, 2018 Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a
Pierre Martinez +8 more
doaj +1 more source
Frontiers in Environmental Science, 2023 Soil salinity is well known heterogeneous and various within natural soil environment. In Songnen grassland of Northeast China, grazing aggravates the saline-alkali heterogeneity in soil habitat, which led to dominant clonal plant species forming a ...
Luhao Qu +9 more
doaj +1 more source
Development of CTL memory despite arrested clonal expansion [PDF]
European Journal of Immunology, 2008 AbstractActivation of a cytotoxic T lymphocyte (CTL) response in an antigen‐exposed lymph node involves a great diversity of encounters between naive CTL and APC that differ in both duration and quality. This broad spectrum of priming events instigates a complex blend of CTL developmental pathways. Using an experimental system that allows tight control
Marianne J B, van Stipdonk +3 more
openaire +2 more sources
PLoS ONE, 2019 Current methods to quantify T-cell clonal expansion only account for variance due to random sampling from a highly diverse repertoire space. We propose a beta-binomial model to incorporate time-dependent variance into the assessment of differentially ...
Julie Rytlewski +6 more
doaj +1 more source