Results 61 to 70 of about 95,784 (161)
Nature Communications, 2020 B7-CD28 co-stimulation is important for T cell activation and clonal expansion in the periphery. Here the authors show that, in mouse thymus, B7-CD28 differentially controls thymocyte clonal deletion and Treg induction, with distinct CD28 signaling ...
Masashi Watanabe +3 more
doaj +1 more source
Clones in blood and stratified epithelial cells, and their drivers
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThe term “clone” is commonly used in the medical and life sciences to denote a genetically identical population, at both the individual and cellular levels. The concept of clonal expansion is of fundamental importance in cancer research.
Shigeru CHIBA
doaj +1 more source
Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms
Nature CommunicationsClonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological ...
Yun Soo Hong +13 more
doaj +1 more source
Cell Reports MedicineSummary: The impact of phenotypic, clonal, and functional heterogeneity of chimeric antigen receptor (CAR)-T cells on clinical outcome remains understudied.
Mercedes Guerrero-Murillo +20 more
doaj +1 more source
Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques
Frontiers in Immunology, 2019 Recent functional, gene expression, and epigenetic studies have suggested the presence of a subset of mature natural killer (NK) cells responsible for maintaining NK cell memory. The lack of endogenous clonal markers in NK cells impedes understanding the
Lauren L. Truitt +15 more
doaj +1 more source
Description of a possible clonal expansion of Plasmodium vivax in Manaus - Amazonas - Brazil
Revista da Sociedade Brasileira de Medicina Tropical, 1999 Atypical P. vivax cases reported in Manaus municipality led us to detect a genetic isolate of P. vivax. Variable regions of SSUrRNA were examined from the initial time of infection and in the two recrudescences/relapses from a patient exhibiting ...
Maria das Graças Costa Alecrim +7 more
doaj
Citation: 'clonal expansion' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13014 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
CellsAutosomal dominant polycystic kidney disease (ADPKD), caused by mutations in PKD1 or PKD2, is characterized by progressive and exponential enlargement of renal and hepatic cysts.
Mengyan Sun +5 more
doaj +1 more source
Evolving copy number gains promote tumor expansion and bolster mutational diversification
Nature CommunicationsThe timing and fitness effect of somatic copy number alterations (SCNA) in cancer evolution remains poorly understood. Here we present a framework to determine the timing of a clonal SCNA that encompasses multiple gains.
Zicheng Wang +7 more
doaj +1 more source
GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV
Emerging Microbes and InfectionsPeople living with HIV (PLWH) exhibit accelerated aging, characterized by systemic inflammation, termed “inflammaging.” While T-cell expansion is prevalent in PLWH, its connection to inflammaging remains unclear.
Hui-Fang Wang +17 more
doaj +1 more source