Results 71 to 80 of about 2,119,256 (322)

Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium

Nature Communications, 2022
Through regeneration, the endometrium accumulates somatic mutations that can lead to diseases like endometriosis and cancer. Here, the authors use genomics to analyse normal endometrial glands from different patient cohorts, detect rhizome structures ...
Manako Yamaguchi, Hirofumi Nakaoka, Kazuaki Suda, Kosuke Yoshihara, Tatsuya Ishiguro, Nozomi Yachida, Kyota Saito, Haruka Ueda, Kentaro Sugino, Yutaro Mori, Kaoru Yamawaki, Ryo Tamura, Sundaramoorthy Revathidevi, Teiichi Motoyama, Kazuki Tainaka, Roel G. W. Verhaak, Ituro Inoue, Takayuki Enomoto   +17 more
doaj   +1 more source

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis

Molecular and Cellular Biology, 2018
Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear.
Masatoshi Kobayashi, M. Ohsugi, Takayoshi Sasako, M. Awazawa, T. Umehara, A. Iwane, Naoki Kobayashi, Yukiko Okazaki, N. Kubota, R. Suzuki, H. Waki, Keiko Horiuchi, T. Hamakubo, T. Kodama, S. Aoe, K. Tobe, T. Kadowaki, K. Ueki   +17 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Biología de la expansión clonal

Iatreia, 2006
La expansión clonal-subclonal, tanto in vivo como in vitro, se caracteriza por la ventaja proliferativa de sub-poblaciones celulares subyacentes.
M. Soto, M. Camargo
doaj  

T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps

Bio-Protocol, 2023
T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount antigen-specific adaptive immune responses.
Massimo Andreatta, Paul Gueguen, Nicholas Borcherding, Santiago Carmona   +3 more
doaj   +1 more source

Abstract 2675: Clonal expansion of skin keratinocyte

Cancer Research, 2021
Abstract Skin is the largest organ system and is exposed to ultraviolet (UV) or sun light, a well-known mutagenic insult in various skin cancers, depending on the body site. A previous study showed that keratinocytes in sun-exposed eyelids harbor a high number of somatic mutations affecting a number of common driver mutations found in ...
Yoshihiro Ishida, Nobuyuki Kakiuchi, Yoichi Fujii, Tomonori Hirano, Yoshikage Inoue, Tomomi Nishimura, Tatsuki Ogasawara, Hirona Maeda, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Atsushi Otsuka, Kenji Kabashima, Seishi Ogawa   +14 more
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cancer risk assessment of premalignant breast tissues from patients with BRCA mutations by genome profiling

npj Breast Cancer
Patients with germline pathogenic variants of BRCA1/2 genes have a particular predisposition to develop breast cancer. No clinical test has been developed to accurately and quantitatively evaluate their risk of developing breast cancer.
Takeshi Hirose, Masachika Ikegami, Kumiko Kida, Toshihide Ueno, Rina Kitada, Lei Wang, Shinya Tanaka, Makoto Endo, Yasuharu Nakashima, Naoki Kanomata, Hiroyuki Mano, Hideko Yamauchi, Shinji Kohsaka   +12 more
doaj   +1 more source

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion

Cell Reports, 2017
Preadipocytes initiate differentiation into adipocytes through a cascade of events. Mitotic clonal expansion, as one of the earliest events, is essential for adipogenesis.
Qiang Chen, Wenhui Hao, Cuiying Xiao, Ruihong Wang, Xiaoling Xu, Huiyan Lu, Weiping Chen, Chu-Xia Deng   +7 more
doaj   +1 more source

Consequences of clonality for sexual fitness: Clonal expansion enhances fitness under spatially restricted dispersal [PDF]

Proceedings of the National Academy of Sciences, 2015
Clonality is a pervasive feature of sessile organisms, but this form of asexual reproduction is thought to interfere with sexual fitness via the movement of gametes among the modules that comprise the clone. This within-clone movement of gametes is expected to reduce sexual fitness via mate limitation of male reproductive success and, in some cases ...
Van Drunen, Wendy E., van Kleunen, Mark, Dorken, Marcel E.   +2 more
openaire   +3 more sources