Results 91 to 100 of about 248,407 (299)

Flower Position and Clonal Integration Drive Intra-Individual Floral Trait Variation in Water-Hyacinth (Eichhornia crassipes, Pontederiaceae)

Biology
Intra-individual variation in floral traits is linked to plant fitness, playing a central role in sexual selection. This variation can arise from architectural constraints, such as flower position on the inflorescence axis, and from environmental factors.
Guilherme Ramos Demetrio, Luziene Seixas, Flávia de Freitas Coelho   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Repeatability of family means in early generations of potato under heat stress

Crop Breeding and Applied Biotechnology, 2011
The selection of potato clones for yield is usually effective from the second clonal generation. It would however be ideal to select from the seedling generation (SG) or the first clonal generation (FCG).
César Augusto Ticona Benavente, César Augusto Brasil Pereira Pinto, Izabel Cristina Rodrigues de Figueiredo, Guilherme Henrique Martins Rodrigues Ribeiro   +3 more
doaj  

Multicriteria vehicle routing problem solved by artificial immune system [PDF]

Transport Problems, 2015
Vehicles route planning in large transportation companies, where drivers are workers, usually takes place on the basis of experience or intuition of the employees.
Bogna MRÓWCZYŃSKA
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimal selection of LQR parameter using AIS for LFC in a multi-area power system

Journal of Mechatronics, Electrical Power, and Vehicular Technology, 2016
This paper proposes a method to optimize the parameter of the linear quadratic regulator (LQR) using artificial immune system (AIS) via clonal selection. The parameters of LQR utilized in this paper are the weighting matrices Q and R.
Muhammad Abdillah, Herlambang Setiadi, Adelhard Beni Reihara, Karar Mahmoud, Imam Wahyudi Farid, Adi Soeprijanto   +5 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Méthodologie de la sélection clonale en Allemagne

OENO One, 1991
Le système allemand de sélection clonale décrit dans l'article est basé sur une sélection par pieds séparés avec réalisation de tests de performances étudiés sur 3 générations, c'est-àdire sur 18 années successives. En particulier, il est étudié à chaque
Harald Schöffling, J. G. Deroo
doaj   +1 more source

Using genotype abundance to improve phylogenetic inference

, 2018
Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times.
DeWitt III, William S., Matsen IV, Frederick A., Mesin, Luka, Minin, Vladimir N., Victora, Gabriel D.   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source