Results 1 to 10 of about 790,447 (335)

Differential innate immune activation by wild-type and NSs-deficient RVFV strains in human blood monocytes [PDF]

Emerging Microbes and Infections
Rift Valley fever virus (RVFV) is a Phlebovirus causing febrile and haemorrhagic illness in ruminants and humans. The viral protein NSs is a major virulence factor that suppresses the IFN-β response in various hosts.
Niranjana Nair, Julia Friese, Paul J. Wichgers Schreur, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan, Chittappen Kandiyil Prajeeth   +5 more
doaj   +2 more sources

Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480. [PDF]

PLoS ONE, 2016
Human cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) can be isolated as side population (SP) cells, aldehyde dehydrogenase high (ALDHhigh) cells or cell surface marker-positive cells including CD44+ cells and CD133+ cells. CSCs/CICs and non-
Akari Takaya, Yoshihiko Hirohashi, Aiko Murai, Rena Morita, Hiroshi Saijo, Eri Yamamoto, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yasuaki Tamura, Ichiro Takemasa, Toru Kondo, Noriyuki Sato, Toshihiko Torigoe   +14 more
doaj   +1 more source

Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death. [PDF]

PLoS ONE, 2010
Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP opening but the outcome of PTP regulation by ubiquinone analogs on cell fate has not been studied ...
Flavien Devun, Ludivine Walter, Julie Belliere, Cécile Cottet-Rousselle, Xavier Leverve, Eric Fontaine   +5 more
doaj   +1 more source

How Naive T-Cell Clone Counts Are Shaped By Heterogeneous Thymic Output and Homeostatic Proliferation

Frontiers in Immunology, 2022
The specificity of T cells is that each T cell has only one T cell receptor (TCR). A T cell clone represents a collection of T cells with the same TCR sequence. Thus, the number of different T cell clones in an organism reflects the number of different T
Renaud Dessalles, Yunbei Pan, Mingtao Xia, Davide Maestrini, Maria R. D’Orsogna, Maria R. D’Orsogna, Tom Chou, Tom Chou   +7 more
doaj   +1 more source

PD-L1 expression with QR1 and E1L3N antibodies according to histological ovarian cancer subtype: A series of 232 cases

European Journal of Histochemistry, 2021
Therapeutic strategies for epithelial ovarian cancers are evolving with the advent of immunotherapy, such as PD-L1 inhibitors, with encouraging results. However, little data are available on PDL-1 expression in ovarian cancers.
Caroline Eymerit-Morin, Anna Ilenko, Thomas Gaillard, Justine Varinot, Eva Compérat, Sofiane Bendifallah, Emile Darai   +6 more
doaj   +1 more source

Antigen presentation by B cells enables epitope spreading across an MHC barrier

Nature Communications, 2023
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn   +22 more
doaj   +1 more source

Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials. [PDF]

PLoS ONE, 2013
Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses. Most infuse T cells genetically modified to express a chimeric antigen receptor (CAR) with specificity derived from the scFv region of a CD19 ...
Bipulendu Jena, Sourindra Maiti, Helen Huls, Harjeet Singh, Dean A Lee, Richard E Champlin, Laurence J N Cooper   +6 more
doaj   +1 more source

Discovering and Differentiating New and Emerging Clonal Populations of Chlamydia trachomatis with a Novel Shotgun Cell Culture Harvest Assay

Emerging Infectious Diseases, 2008
Chlamydia trachomatis is the leading cause of preventable blindness and bacterial sexually transmitted diseases worldwide. Plaque assays have been used to clonally segregate laboratory-adapted C.
Naraporn Somboonna, Sally Mead, Jessica Liu, Deborah Dean   +3 more
doaj   +1 more source

Modeling large fluctuations of thousands of clones during hematopoiesis: The role of stem cell self-renewal and bursty progenitor dynamics in rhesus macaque. [PDF]

PLoS Computational Biology, 2018
In a recent clone-tracking experiment, millions of uniquely tagged hematopoietic stem cells (HSCs) and progenitor cells were autologously transplanted into rhesus macaques and peripheral blood containing thousands of tags were sampled and sequenced over ...
Song Xu, Sanggu Kim, Irvin S Y Chen, Tom Chou   +3 more
doaj   +1 more source

Identification of TCR Vβ11-2-Dβ1-Jβ1-1 T cell clone specific for WT1 peptides using high-throughput TCRβ gene sequencing

Biomarker Research, 2019
We previously identified a TCR Vβ21 T cell clone which was specific to CML patients, and demonstrated that TCR Vα13/β21 gene-modified CD3+ T cells had specific cytotoxicity for HLA-A11+ K562 cells.
Yikai Zhang, Ling Xu, Shaohua Chen, Xianfeng Zha, Wei Wei, Yangqiu Li   +5 more
doaj   +1 more source