Characterization and comparison of 2 distinct epidemic community-associated methicillin-resistant Staphylococcus aureus clones of ST59 lineage. [PDF]
PLoS ONE, 2013 Sequence type (ST) 59 is an epidemic lineage of community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) isolates. Taiwanese CA-MRSA isolates belong to ST59 and can be grouped into 2 distinct clones, a virulent Taiwan clone and a ...
Chih-Jung Chen +5 more
doaj +9 more sources
Differential innate immune activation by wild-type and NSs-deficient RVFV strains in human blood monocytes [PDF]
Emerging Microbes and InfectionsRift Valley fever virus (RVFV) is a Phlebovirus causing febrile and haemorrhagic illness in ruminants and humans. The viral protein NSs is a major virulence factor that suppresses the IFN-β response in various hosts.
Niranjana Nair +5 more
doaj +2 more sources
Establishment and Analysis of Cancer Stem-Like and Non-Cancer Stem-Like Clone Cells from the Human Colon Cancer Cell Line SW480. [PDF]
PLoS ONE, 2016 Human cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) can be isolated as side population (SP) cells, aldehyde dehydrogenase high (ALDHhigh) cells or cell surface marker-positive cells including CD44+ cells and CD133+ cells. CSCs/CICs and non-
Akari Takaya +14 more
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Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death. [PDF]
PLoS ONE, 2010 Prolonged opening of the mitochondrial permeability transition pore (PTP) leads to cell death. Various ubiquinone analogs have been shown to regulate PTP opening but the outcome of PTP regulation by ubiquinone analogs on cell fate has not been studied ...
Flavien Devun +5 more
doaj +1 more source
Frontiers in Immunology, 2022 The specificity of T cells is that each T cell has only one T cell receptor (TCR). A T cell clone represents a collection of T cells with the same TCR sequence. Thus, the number of different T cell clones in an organism reflects the number of different T
Renaud Dessalles +7 more
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European Journal of Histochemistry, 2021 Therapeutic strategies for epithelial ovarian cancers are evolving with the advent of immunotherapy, such as PD-L1 inhibitors, with encouraging results. However, little data are available on PDL-1 expression in ovarian cancers.
Caroline Eymerit-Morin +6 more
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Antigen presentation by B cells enables epitope spreading across an MHC barrier
Nature Communications, 2023 Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert +22 more
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Emerging Infectious Diseases, 2008 Chlamydia trachomatis is the leading cause of preventable blindness and bacterial sexually transmitted diseases worldwide. Plaque assays have been used to clonally segregate laboratory-adapted C.
Naraporn Somboonna +3 more
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Chimeric antigen receptor (CAR)-specific monoclonal antibody to detect CD19-specific T cells in clinical trials. [PDF]
PLoS ONE, 2013 Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses. Most infuse T cells genetically modified to express a chimeric antigen receptor (CAR) with specificity derived from the scFv region of a CD19 ...
Bipulendu Jena +6 more
doaj +1 more source
Mechanisms of blood homeostasis: lineage tracking and a neutral model of cell populations in rhesus macaques. [PDF]
, 2015 BACKGROUND:How a potentially diverse population of hematopoietic stem cells (HSCs) differentiates and proliferates to supply more than 10(11) mature blood cells every day in humans remains a key biological question.
Chen, Irvin SY +3 more
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