Results 21 to 30 of about 790,447 (335)

Myocardial aging as a T-cell–mediated phenomenon [PDF]

, 2017
In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies.
Abeßer, Marco, Beyersdorf, Niklas, Burkard, Matthias, Frantz, Stefan, Friedrich, Mike, Heinze, Katrin G., Hofmann, Ulrich, Jocelyne, Demengeot, Kerkau, Thomas, Nunes-Silva, Vânia, Peters, Laura, Pinnecker, Jürgen, Ramos, Gustavo Campos, Schuh, Kai, van den Berg, Anne, Weirather, Johannes   +15 more
core   +1 more source

Imaging cell lineage with a synthetic digital recording system [PDF]

, 2020
Cell lineage plays a pivotal role in cell fate determination. Chow et al. demonstrate the use of an integrase-based synthetic barcode system called intMEMOIR, which uses the serine integrase Bxb1 to perform irreversible nucleotide edits.
Budde, Mark W., Cabrera, Maria, Cai, Long, Cho, Soomin, Chow, Ke-Huan K., Elowitz, Michael B., Frieda, Kirsten L., Granados, Alejandro A., Huang, Ting-hao, Koulena, Noushin, Lois, Carlos, Yoon, Shinae   +11 more
core   +1 more source

Increased HERV-E clone 4–1 expression contributes to DNA hypomethylation and IL-17 release from CD4+ T cells via miR-302d/MBD2 in systemic lupus erythematosus

Cell Communication and Signaling, 2019
Background Increased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1) mRNA expression is observed in systemic lupus erythematosus (SLE) patients and associates with the disease activity.
Xin Wang, Chaoshuai Zhao, Chengzhong Zhang, Xingyu Mei, Jun Song, Yue Sun, Zhouwei Wu, Weimin Shi   +7 more
doaj   +1 more source

Reconstructing tumor evolutionary histories and clone trees in polynomial-time with SubMARine.

PLoS Computational Biology, 2021
Tumors contain multiple subpopulations of genetically distinct cancer cells. Reconstructing their evolutionary history can improve our understanding of how cancers develop and respond to treatment.
Linda K Sundermann, Jeff Wintersinger, Gunnar Rätsch, Jens Stoye, Quaid Morris   +4 more
doaj   +1 more source

To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture. [PDF]

PLoS ONE, 2013
Induced pluripotent stem cells (iPSCs) are usually clonally derived. The selection of fully reprogrammed cells generally involves picking of individual colonies with morphology similar to embryonic stem cells (ESCs).
Charlotte A Willmann, Hatim Hemeda, Lisa A Pieper, Michael Lenz, Jie Qin, Sylvia Joussen, Stephanie Sontag, Paul Wanek, Bernd Denecke, Herdit M Schüler, Martin Zenke, Wolfgang Wagner   +11 more
doaj   +1 more source

A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis

Journal of Neuroinflammation, 2012
Background Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147, basigin) is an inducer of the expression of several matrix metalloproteinases (MMPs).
Agrawal Smriti M, Silva Claudia, Wang Janet, Tong Jade, Yong V   +4 more
doaj   +1 more source

Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]

, 2013
Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P., Cooper, A., Curreli, F., Debnath, A.K., Freed, E.O., Lee, S., Mehta, M., Mercredi, P.Y., Scacalossi, D., Summers, M.F., Tong, X., Waheed, A.A., Zhang, H.   +12 more
core   +2 more sources

PD-L1 expression and the prognostic significance in gastric cancer: a retrospective comparison of three PD-L1 antibody clones (SP142, 28–8 and E1L3N)

Diagnostic Pathology, 2018
Background Immunohistochemistry (IHC) for programmed cell death ligand 1 (PD-L1) displays staining diversity. We compared IHC staining of PD-L1 in gastric cancer (GC) by using three commercially available antibody clones, and analyzed the correlation ...
Jing Ma, Jianhui Li, Meirui Qian, Weili Han, Miaomiao Tian, Zengshan Li, Zhe Wang, Shuixiang He, Kaichun Wu   +8 more
doaj   +1 more source

Cloning human stem cells [PDF]

Canadian Medical Association Journal, 2004
![Figure][1] Figure. Photo by: Myra Rudakewich Pluripotent human embryonic stem cells have a unique ability to differentiate into any cell line. Although this has raised hopes that transplantation of stem cells may halt or reverse degenerative disorders such as diabetes and Parkinson ...
openaire   +2 more sources

Long-term cultivation of two diploid epithelial cell lines derived from normal rat liver cells [PDF]

, 1974
To obtain a useful rat liver cell line for in vitro carcinogenesis, two rat diploid epithelial cell lines were established from a 7-day-old male rat by the repeated colonial clone method.
Masuji, Hiroshi, Nakabayashi, Hidekazu, Sato, Jiro   +2 more
core   +1 more source