Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]
, 2017 Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario +13 more
core +1 more source
Phenotypic evolution in microalgae: a dramatic morphological shift in Dictyosphaerium chlorelloides (Chlorophyta) after exposure to TNT [PDF]
, 2006 Phenotypic evolution in microalgae: a dramatic morphological shift in Dictyosphaerium chlorelloides (Chlorophyta) after exposure to TNT. The occurrence of rapid morphological evolution in the microalga Dictyosphaerium chlorelloides (Chlorophyta) was ...
Costas, Eduardo +3 more
core +3 more sources
Haematologica, 2010 Background Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and are present in about 40–50% of patients with severe aplastic anemia.
Phillip Scheinberg +3 more
doaj +1 more source
Di-san junyi daxue xuebao, 2020 Objective To study the effect of down-regulation of long non-coding RNA (lncRNA) HOXA cluster antisense RNA 2 (HOXA-AS2)/miR-20a pathway on apoptosis and invasion of skin squamous cell carcinoma cells in vitro.
XU Wen, LIU Xuhong, LIU Hua
doaj +1 more source
Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse. [PDF]
PLoS ONE, 2015 Induced pluripotent stem cells (iPSCs) have tremendous potential as a tool for disease modeling, drug testing, and other applications. Since the generation of iPSCs "captures" the genetic history of the individual cell that was reprogrammed, iPSC clones (
Cheng Li +11 more
doaj +1 more source
Characterization, cloning and immunogenicity of antigens released by transforming cercariae of Schistosoma mansoni [PDF]
, 2000 A schistosome infection is initiated when the parasite penetrates the skin of a susceptible host. Relatively large quantities of protein are released by transforming cercariae compared to later larval stages.
Coulson, P.S. +4 more
core +1 more source
Dual-acting stapled peptides target both HIV-1 entry and assembly [PDF]
, 2013 Background: Previously, we reported the conversion of the 12-mer linear and cell-impermeable peptide CAI to a cell-penetrating peptide NYAD-1 by using an i,i + 4 hydrocarbon stapling technique and confirmed its binding to the C-terminal domain (CTD ...
Bhargava, P. +12 more
core +2 more sources
ReMixT: clone-specific genomic structure estimation in cancer
Genome Biology, 2017 Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sampled populations,
Andrew W. McPherson +10 more
doaj +1 more source
Long-term cultivation of two diploid epithelial cell lines derived from normal rat liver cells [PDF]
, 1974 To obtain a useful rat liver cell line for in vitro carcinogenesis, two rat diploid epithelial cell lines were established from a 7-day-old male rat by the repeated colonial clone method.
Masuji, Hiroshi +2 more
core +1 more source
Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. [PDF]
PLoS ONE, 2016 Parkinson's disease is characterized by the death of dopaminergic neurons in the substantia nigra. To understand the molecular mechanisms of the disease, an in vitro model is important.
Lu Gao +3 more
doaj +1 more source