Results 241 to 250 of about 5,018,281 (306)

Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis

Advanced Healthcare Materials, EarlyView.
Melanoma cell spheroid engraftment is optimized in the chicken chorioallantoic membrane overcoming the complexity of other in vivo models. Using this model, greater penetration of cerium oxide nanoparticles (nanoceria) functionalized with heparin in spheroids is observed via enhancement of vascularization than nanoceria alone.
Lu Fu, Joel M. Yong, Robyn Yeh, Florence Bartlett, John M. Whitelock, Megan S. Lord   +5 more
wiley   +1 more source

Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation

Advanced Healthcare Materials, EarlyView.
This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth, Zachary S.C.S. Froom, Natasha D. Osborne, Christian N. Rempe, Brenden Wheeler, Kyle Medd, Neal I. Callaghan, Huikang Qian, Abhinav P. Acharya, Carlie Charron, Locke Davenport Huyer   +10 more
wiley   +1 more source

In Silico Design and Characterization of a Multiepitope Vaccine Candidate Against <i>Brucella canis</i> Using a Reverse Vaccinology Approach. [PDF]

J Immunol Res
Arriagada V, Osorio A, Carrera-Naipil C, Villacis-Aguirre CA, Escobar C, Morales N, Villa D, Mardones L, Pérez D, Jara M, Molina RE, Ferrari Í, Azocar S, Gómez LA, Oñate ÁA.   +14 more
europepmc   +1 more source

High‐Resolution Patterned Delivery of Chemical Signals From 3D‐Printed Picoliter Droplet Networks

Advanced Materials, EarlyView.
3D‐printed picoliter droplet networks have been fabricated that control gene expression in bacterial populations by releasing chemical signals with precise spatial definition and high temporal resolution. This system of effector release is widely applicable, offering diverse applications in biology and medicine.
Jorin Riexinger, Thomas Caganek, Xingzao Wang, Yutong Yin, Khoa Chung, Linna Zhou, Hagan Bayley, Ravinash Krishna Kumar   +7 more
wiley   +1 more source

Leveraging Circular Polymerization and Extension Cloning (CPEC) Method for Construction of CRISPR Screening Libraries. [PDF]

Bio Protoc
Dayanc B, Eris S, Senturk S.
europepmc   +1 more source

High‐Yield Bioproduction of Extracellular Vesicles from Stem Cell Spheroids via Millifluidic Vortex Transport

Advanced Materials, EarlyView.
Stem cell spheroids, produced via a high‐throughput microfabrication technique, are transported within a vortex generated at the outlet channels of a cross‐slot millifluidic chip. For Reynolds number exceeding 170–200, intermittent high shear stresses applied to each spheroid within the vortex trigger a massive release of biologically active ...
Elliot Thouvenot, Laura Charnay, Noa Burshtein, Jean‐Michel Guigner, Léonie Dec, Damarys Loew, Amanda K.A. Silva, Anke Lindner, Claire Wilhelm   +8 more
wiley   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

Subtractive proteomics and reverse-vaccinology approaches for novel drug targets and designing a chimeric vaccine against <i>Ruminococcus gnavus</i> strain RJX1120. [PDF]

Front Immunol
Dingding H, Muhammad S, Manzoor I, Ghaffar SA, Alodaini HA, Moubayed NM, Hatamleh AA, Songxiao X.   +7 more
europepmc   +1 more source

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Rapid isolation of Yr9 via MutIsoSeq and QTL analysis of durable stripe rust resistance in wheat cultivar Xingzi 9104. [PDF]

Stress Biol
Zhang Y, Huang S, Li Y, Cao S, Ren H, Xiang M, Dong H, Han J, Zhao Y, Zhang X, Yuan X, Wang Q, Wang Y, Ouyang Y, Yang Z, Kang Z, Liu S, Wu J, Zeng Q, Han D.   +19 more
europepmc   +1 more source