Results 271 to 280 of about 5,018,281 (306)

A leucine responsive small RNA AbcR200 regulates expression of the lactate utilization (lut) operon in Acinetobacter baumannii DS002. [PDF]

J Biol Chem
Yakkala HN, Madikonda AK, Behera SR, Pillalamarri V, Mohammad KG, Dhurve G, Tammineni P, Pakala SB, Siddavattam D.   +8 more
europepmc   +1 more source

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy

Advanced Science, EarlyView.
This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan, Qianyu Li, Guoquan Yan, Yifei Qian, Wenyun Guo, Songling Li, Fan Wang, Wanjing Shang, Zijun Zhu, Di Ge, Yanan Wang, Yanfeng Liu   +11 more
wiley   +1 more source

Designing a potent multivalent epitope vaccine candidate against Orientia tsutsugamushi via reverse vaccinology technique - bioinformatics and immunoinformatic approach. [PDF]

Front Immunol
Panda S, Swain SK, Sahu BP, Mahapatra SR, Dey J, Sarangi R, Ranade AV, Mishra N.   +7 more
europepmc   +1 more source

Malignant Hepatoblast‐Like Cells Sustain Stemness via IGF2‐Dependent Cholesterol Accumulation in Hepatoblastoma

Advanced Science, EarlyView.
Hepatoblastoma, an aggressive childhood liver tumor, origins from malignant hepatoblast‐like cells. Single‐cell analysis reveals IGF2‐driven pathways promoting malignancy. Targeting these pathways offers promising treatments, with serum IGF2 as a potential diagnostic biomarker.
Miao Ding, Siwei Mao, Han Wu, Sijia Fang, Ni Zhen, Tianshu Chen, Jiabei Zhu, Xiaochen Tang, Xiaoyang Wang, Fenyong Sun, Guoqing Zhu, Qiuhui Pan, Ji Ma   +12 more
wiley   +1 more source

cDNA Cloning, Bioinformatics, and Expression Analysis of <i>ApsANS</i> in <i>Acer pseudosieboldianum</i>. [PDF]

Int J Mol Sci
Li M, Weng Z, Gong Z, Li X, Ye J, Gao Y, Rong L.   +6 more
europepmc   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Novel tools for genomic modification and heterologous gene expression in the phylum Planctomycetota. [PDF]

Appl Microbiol Biotechnol
Haufschild T, Hammer J, Rabold N, Plut V, Jogler C, Kallscheuer N.   +5 more
europepmc   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Targeted Forward Genetics: Saturating Mutational Analyses of Specific Target Loci Within the Genome. [PDF]

Methods Mol Biol
Protacio RU, Wahls WP.
europepmc   +1 more source

Current Approaches for Genetic Manipulation of <i>Streptomyces</i> spp.-Key Bacteria for Biotechnology and Environment. [PDF]

BioTech (Basel)
Krysenko S.
europepmc   +1 more source