Results 71 to 80 of about 169,670 (196)

Cell type composition and circuit organization of neocortical radial clones [PDF]

, 2019
SummaryExcitatory neurons arising from a common progenitor establish radially-oriented clonal units in the neocortex which have been proposed to serve as elementary information processing modules. To characterize the cell types and circuit diagram within these clonal units, we performed single-cell RNA-sequencing and multi-cell patch clamp recordings ...
R. James Cotton, Andreas S. Tolias, Andreas S. Tolias, Rickard Sandberg, Fabian H. Sinz, Fabian H. Sinz, Philipp Berens, Cathryn R. Cadwell, Cathryn R. Cadwell, Paul G. Fahey, Federico Scala, Xiaolong Jiang, Shuang Li, Per Johnsson, Dmitry Kobak   +14 more
openaire   +3 more sources

Nitrogen regulation of protein–protein interactions and transcript levels of GlnK PII regulator and AmtB ammonium transporter homologs in Archaea [PDF]

, 2013
Gene homologs of GlnK PII regulators and AmtB-type ammonium transporters are often paired on prokaryotic genomes, suggesting these proteins share an ancient functional relationship.
Adler, Allers, Andrade, Atkinson, Bell, Bitan-Banin, Bonete, Camacho, Chellamuthu, Cline, Conroy, Coutts, Detsch, Dodsworth, Eichler, Garber, Gruswitz, Hammelmann, Han, Hervás, Huergo, Huergo, Huergo, Javelle, Javelle, Jiang, Khademi, Lee, Liu, Maier, Mangum, Martínez-Espinosa, Martínez-Espinosa, Moure, Najera-Fernandez, Pedro-Roig, Pedro-Roig, Pedro-Roig, Radchenko, Rodriguez-Valera, Russek, Sant'Anna, Severi, Strösser, Thomas, Thornton, Tremblay, Weiss, Werner, Xu, Zamaroczy, Zhang, Zhang, Zheng   +53 more
core   +2 more sources

Engineering a DYRK1B R102C mutation: insights into metabolic syndrome pathogenesis through lentiviral gene delivery [PDF]

Medical Laboratory Journal
Background: A rare heterozygous DYRK1B mutation (R102C) recently linked to a familial form of metabolic syndrome prompted this study to introduce the R102C mutation into the mouse DYRK1B gene, utilizing recombinant lentiviruses for long-term gene ...
Afrooz Daneshparvar, Iman Jamhiri, Vahid Razban, Jafar Fallahi, Nasrin Hamidizadeh, Behnam Moghtaderi, Mehdi Dianatpour   +6 more
doaj  

Strategies for the evolution of sex [PDF]

, 2001
We find that the hypothesis made by Jan, Stauffer and Moseley [Theory in Biosc., 119, 166 (2000)] for the evolution of sex, namely a strategy devised to escape extinction due to too many deleterious mutations, is sufficient but not necessary for the ...
A. Bernardes, A. Kondrashov, A. Pekalski, Ayşe Erzan, B. Chopard, B. Drossel, B. Örcal, C. Chisholm, D. Stauffer, D. Stauffer, E.J. Lyons, E.P. Solomon, Erkan Tüzel, H.L. Muller, J. Maynard Smith, J. Maynard Smith, J. Maynard Smith, J. Thoms, J.M. Smith, J.S. SaMartins, L.M. Prescott, M. Eigen, N. Jan, R.J. Redfield, S.S. Mader, T.J. Penna, Volkan Sevim, W.D. Hamilton, Y. Cui   +28 more
core   +2 more sources

Target Gene Inactivation in Cyanobacterium Anabaena sp. PCC 7120

Bio-Protocol, 2016
Anabaena sp. strain PCC 7120 has long served as a model organism for investigating N2-fixation, photosynthesis, and various plant-type metabolic pathways and biofuel production, as well as cellular differentiation (Xu et al., 2008, Halfmann et al., 2014,
Kangming Chen, Huilan Zhu, Liping Gu, Shengni Tian, Ruanbao Zhou   +4 more
doaj   +1 more source

Transformation of the Methylotrophic Actinomycete Amycolatopis methanolica with Plasmid DNA: Stimulatory Effect of a pMEA300-Encoded Gene [PDF]

, 1995
Amycolatopsis methanolica contains a 13.29-kb plasmid (pMEA300) present both in the free state and integrated at a unique genomic location. A pMEA300-free derivative (strain WV1) was selected, allowing further analysis of pMEA300-encoded functions. Whole
Dijkhuizen, L.,, Madoń, J.,, Vrijbloed, J.W.,   +2 more
core   +2 more sources

Molecular characterization of a novel intracellular ADP-ribosyl cyclase.

PLoS ONE, 2007
BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani, Michael J Boulware, Timothy J Geach, Andrew C R Martin, Gary W Moy, Yi-Hsien Su, Victor D Vacquier, Jonathan S Marchant, Leslie Dale, Sandip Patel   +9 more
doaj   +1 more source

Parallel DNA pyrosequencing unveils new zebrafish microRNAs

BMC Genomics, 2009
Background MicroRNAs (miRNAs) are a new class of small RNAs of approximately 22 nucleotides in length that control eukaryotic gene expression by fine tuning mRNA translation.
Arrais Joel, Gomes Ana C, Egas Conceição, Santos Bruno, Pereira Patrícia M, Soares Ana R, Oliveira José L, Moura Gabriela R, Santos Manuel AS   +8 more
doaj   +1 more source

Melatonin receptor expression in the zebra finch brain and peripheral tissues [PDF]

, 2012
The circadian endocrine hormone melatonin plays a significant role in many physiological processes such as modulating sleep/wake cycle and oxidative stress.
Brandstaetter, Roland, Helfer, Gisela, Jones, Catherine   +2 more
core   +1 more source

Construction and comparison of different vehicles for heterologous gene expression in Zymomonas mobilis

Microbial Biotechnology
Zymomonas mobilis has the potential to be an optimal chassis for the production of bulk chemicals derived from pyruvate. However, a lack of available standardized and characterized genetic tools hinders both efficient engineering of Z.
Gerrich Behrendt, Maria Vlachonikolou, Helga Tietgens, Katja Bettenbrock   +3 more
doaj   +1 more source