Results 61 to 70 of about 437,074 (308)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Cloning and Functional Expression of A Mouse Liver Organic Cation Transporter [PDF]
Hepatology, 1999 Hepatic uptake of organic cations is essential for the metabolism and secretion of numerous endobiotics and drugs. Several hepatic organic cation transporters have been kinetically defined, yet have not been isolated or cloned.
R M, Green +3 more
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Human Cloning Research. National Academy of Sciences Forum (2001 August 7) (Part 1)
, 2001 The scientists provided background information on a variety of topics, including embryology, scientific issues underlying cloning, and the role of mitochondria.
Producer: National Cable Satellite Corporation. C-SPAN
core
Organism-specific vs. reference pathways.
, 2021 Number of SEP (P ≤ 0.1) detected in both the KEGG organism-specific and KEGG reference pathway sets, and those significant in only one of the sets.
Cecilia Wieder (11402540) +9 more
core +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Biochemistry of microbial itaconic acid production
Frontiers in Microbiology, 2013 Itaconic acid is an unsatured dicarbonic acid which has a high potential as a biochemical building block, because it can be used as a monomer for the production of a plethora of products including resins, plastics, paints and synthetic fibers.
Matthias Georg Steiger +8 more
doaj +1 more source
Human Reproductive Cloning. National Academy of Sciences Forum (2001 August 7) (Part 2)
, 2001 "In sometimes heated exchanges, a panel of experts [NAS Public Panel on Human Reproductive Cloning] questioned scientists about their plans to begin human cloning research. Among the issues addressed were ethical concerns, the safety of cloning research,
Producer: National Cable Satellite Corporation. C-SPAN
core
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source