Results 111 to 120 of about 1,949,061 (374)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Identification of the transcript isoforms and expression characteristics for chicken Lpin1

Animal, 2012
Lpin1 was a gene with important effects on controlling lipid/energy metabolism in humans and mice. However, little was known about chicken Lpin1 gene. In the present study, two transcript isoforms of chicken Lpin1 were identified.
X.K. Wang, W. Chen, Y.Q. Huang, X.T. Kang, J.P. Wang, G.X. Li, R.R. Jiang   +6 more
doaj   +1 more source

Assessing intratumor heterogeneity and tracking longitudinal and spatial clonal evolutionary history by next-generation sequencing [PDF]

, 2016
Yuchao Jiang, Yu Qiu, Andy J. Minn, Nancy R. Zhang   +3 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

Animal, 2014
MicroRNAs are endogenous ~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3′-untranslated region (3′UTR) of target mRNAs.
T. Yang, X.L. Chen, Z.Q. Huang, W.X. Wen, M. Xu, D.W. Chen, B. Yu, J. He, J.Q. Luo, J. Yu, X.B. Mao, P. Zheng   +11 more
doaj   +1 more source

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria [PDF]

, 1996
K. Kawagoe, Daisuke Kitamura, Masaru Okabe, Ichiro Taniuchi, Masahito Ikawa, Takeshi Watanabe, Taroh Kinoshita, Junji Takeda   +7 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

‘You Never Thought about Me, Did You?’ Cloning and the Right to Reproductive Choice in Eva Hoffman’s The Secret (2001)

Humanities
This article will critically appraise the extent to which new developments in the fields of reproductive technology are shown to impact female bodily autonomy and reproductive choice in Eva Hoffman’s novel The Secret.
Laura-Jane Devanny
doaj   +1 more source

Cloning, expression pattern and functional characterization of fused, an important kinase of the Hedgehog signalling pathway from Locusta migratoria (Orthoptera: Acridoidea)

Biotechnology & Biotechnological Equipment, 2019
Locusta migratoria is one of the global destructive migratory agricultural pests. The species serves as a model insect for the study of morphology, physiology, developmental biology, and neurosciences and so on.
Xiaohong Zhang, Li Feng, Ning Qiao, Yachao Liu, Dao Chuan Zhang, Hong Yin   +5 more
doaj   +1 more source

Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma [PDF]

, 2016
Niels Weinhold, Cody Ashby, Leo Rasche, Shweta S. Chavan, Joshua Epstein, Owen Stephens, Ruslana G. Tytarenko, Michael Bauer, Tobias Meißner, Shayu Deshpande, Purvi H. Patel, Tímea Buzder, Gábor Molnár, Erich A. Peterson, Frits van Rhee, Maurizio Zangari, Sharmilan Thanendrarajan, Carolina Schinke, Erming Tian, Joshua Epstein, Bart Barlogie, Faith E. Davies, Christoph Heuck, Brian A. Walker, Gareth J. Morgan   +24 more
openalex   +1 more source