Results 101 to 110 of about 34,117 (261)

Identification of Biosynthetic Inhibitors of Virulence Factor Entry Into Mammalian Cells [PDF]

, 2023
Clostridioides difficile toxin B (TcdB) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the primary virulence factors behind the C.
Icho, Simoun
core   +1 more source

Modeling inpatient and outpatient antibiotic stewardship interventions to reduce the burden of Clostridioides difficile infection in a regional healthcare network [PDF]

, 2020
Antibiotic exposure can lead to unintended outcomes, including drug-drug interactions, adverse drug events, and healthcare-associated infections like Clostridioides difficile infection (CDI). Improving antibiotic use is critical to reduce an individual's
Bobashev, G., CDC MInD-Healthcare Network, DiBiase, L., Endres-Dighe, S., Hilscher, R., Jones, K., Lewis, J., MacFarquhar, J., Marx, A., Munoz, B., Rhea, S., Rineer, J., Sickbert-Bennett, E., Weber, D.J.   +13 more
core   +2 more sources

Collagenous colitis in patients treated for cancer: role of immune checkpoint inhibitors. Clinical, histological and immunological features in 15 cases

Histopathology, EarlyView.
Immune checkpoint inhibitor‐associated collagenous colitis exhibits distinct histopathological and immunophenotypic features compared to idiopathic cases, including prominent sub‐epithelial macrophage accumulation and neutrophilic cryptitis. These findings underscore the pathogenic impact of PD1/PD‐L1 axis blockade on colonic mucosa and expand the ...
Mohamed‐Amine Bani, Peggy Dartigues, Ranya Soufan, Simona Cosconea, Michel Ducreux, Caroline Robert, Edouard Guenzi, François‐Xavier Danlos, Aurélien Marabelle, Franck Carbonnel, Jean‐Yves Scoazec   +10 more
wiley   +1 more source

Management of Clostridioides difficile Infection [PDF]

Critical Care Nurse, 2019
Clostridioides (formerly Clostridium) difficile infection is among the most identified causes of health care-associated infections in US hospitals and remains a major public health problem. The incidence and severity of C difficile infection are high among critically ill patients.
Stephanie Quist, Renata Shamis, Christina Clarkin, Amber E. King, Bhavik M. Shah   +4 more
openaire   +3 more sources

Whole genome sequence analysis reveals limited diversity among Clostridioides difficile ribotype 027 and 078 isolates collected in 22 hospitals in Berlin and Brandenburg, Germany

Antimicrobial Resistance and Infection Control
Background Clostridioides difficile infections (CDI) present significant health risks and are among the most important nosocomial infections. Ribotype (RT) 027 poses a particular risk due to its proposed “hypervirulence”. Traditionally, C.
Esther E. Dirks, Vanessa Pfiffer, Genevieve Sohl, Fabian K. Berger, Ina Friesen, Johannes Friesen, Ralf Ignatius, Johannes Elias, Alexander Mellmann, Mardjan Arvand   +9 more
doaj   +1 more source

Clostridioides difficile co-infection with Enterohemorrhagic Escherichia coli (EHEC)—a potentially fatal combination

IDCases, 2020
There has been a significant increase in hospital and community acquired Clostridioides difficile infection in the past decade. In addition to CDI, the rate of infection with enterohemorrhagic Escherichia coli (EHEC) has also increased by 28% in United ...
Farah Deshmukh, Upasana Agrawal, Nancy Merrell   +2 more
doaj   +1 more source

The impact of the COVID‐19 pandemic on longitudinal trends of surgical mortality and inpatient quality of care in Ontario, Canada

Journal of Advanced Nursing, EarlyView.
Abstract Aims Previous studies have shown the COVID‐19 pandemic was associated with reductions in volume across a spectrum of non‐SARS‐CoV‐2 hospitalizations. In the present study, we examine the impact of the pandemic on patient safety and quality of care. Design This is a retrospective population‐based study of discharge abstracts. Methods We applied
Steven Habbous, Maggie Ford, Stacey Bar‐Ziv, Terri Donovan, Erik Hellsten   +4 more
wiley   +1 more source

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

Nature Communications, 2021
The effects of antibiotics on the gut microbiota can lead to enhanced colonization of Clostridioides difficile (C. difficile) and toxin-mediated pathogenesis.
Joshua R. Fletcher, Colleen M. Pike, Ruth J. Parsons, Alissa J. Rivera, Matthew H. Foley, Michael R. McLaren, Stephanie A. Montgomery, Casey M. Theriot   +7 more
doaj   +1 more source

Pharmacologic Management of Non‐Traumatic Dental Conditions in US Emergency Departments, 2018–2022

Journal of Public Health Dentistry, EarlyView.
ABSTRACT Objective This study examines opioid and antibiotic prescribing by United States emergency departments (EDs) for non‐traumatic dental conditions (NTDCs) between 2018 and 2022. Methods This is a secondary analysis of nationally representative ED visits using the National Hospital Ambulatory Medical Care Survey (NHAMCS) with an NTDC as the ...
Leah I. Leinbach, Xiaobai Li, Timothy Iafolla, Hosam Alraqiq   +3 more
wiley   +1 more source

Is Rifampin (Rifampicin) Essential for the Treatment of Rhodococcus equi Infections in Foals? A Critical Review of the Role of Rifampin

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Rifampin is an enigma among antimicrobials. Blood and tissue compartment concentrations are a “moving target” along the treatment course due to the complex pharmacodynamic interactions within the body. Rifampin concomitant therapies are for the prevention and treatment of Rhodococcus equi infection in foals, for nearly 40 years.
Keith Edward Baptiste, Niels Christian Kyvsgaard, Mohamed Omar Ahmed, Peter Damborg, Patricia M. Dowling   +4 more
wiley   +1 more source