Results 121 to 130 of about 31,246 (217)

Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Biofilms formed by mycobacteria, particularly Mycobacterium tuberculosis (Mtb), represent a major challenge in tuberculosis (TB) treatment due to their highly organized structure and their capacity to induce phenotypic drug tolerance. These three‐dimensional bacterial aggregates are embedded in a self‐produced extracellular matrix that ...
Lourdes Serrano Garcia, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan, Marlus Chorilli   +3 more
wiley   +1 more source

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Cell Reports
Summary: The G protein-coupled receptors of the Frizzled (FZD) family, in particular FZD1,2,7, are receptors that are exploited by Clostridioides difficile toxin B (TcdB), the major virulence factor responsible for pathogenesis associated with ...
Julia Kinsolving, Julien Bous, Pawel Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, Geoffrey Masuyer, Yuankai Wang, Pål Stenmark, Min Dong, Gunnar Schulte   +10 more
doaj   +1 more source

The Clinical Impact of Antibiotic Allergy Labels on One‐Year Outcomes of Solid Organ Transplant Recipients

Clinical Transplantation, Volume 40, Issue 3, March 2026.
ABSTRACT Antibiotic allergy labels (AALs) are common and often incorrect. They have many potential impacts, including the use of broader‐spectrum antibiotics and suboptimal treatment of infections. The impact of inaccurate allergy labels on post‐transplant outcomes in the solid organ transplant population is not well described.
Sashi Niranjan Nair, Paul Bigliardi, Lauren Fontana   +2 more
wiley   +1 more source

A novel kirkovirus may be associated with equine gastrointestinal disease

Equine Veterinary Journal, Volume 58, Issue 2, Page 414-422, March 2026.
Abstract Background Many cases of equine enterocolitis are suspected to be infectious in nature, but no pathogen is identified in many cases. Objectives Perform next‐generation sequencing on faeces collected from cases of equine enterocolitis for the presence of novel viruses and determine if an identified novel virus is associated with cases of equine
Lillian M. B. Haywood, Ava Clark, Ben Hause, Breanna Sheahan   +3 more
wiley   +1 more source

The Emerging Role of Gut Microbiota in Inflammatory Skin Diseases: A Systematic Review

Experimental Dermatology, Volume 35, Issue 3, March 2026.
ABSTRACT The human gut microbiota is involved in immune regulation, metabolism, and skin homeostasis. In recent years, gut microbiota alterations have been linked with several inflammatory skin disorders, such as atopic dermatitis (AD), psoriasis, and hidradenitis suppurativa (HS).
Andrea Malgesini, Matteo Domenico Marsiglia, Elisa Borghi, Angelo V. Marzano, Gianluca Nazzaro   +4 more
wiley   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 880-894, March 2026.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease

Annals of the New York Academy of Sciences, Volume 1557, Issue 1, March 2026.
Bringing together experts in reflux diseases, including gastroenterologists, surgeons, endoscopists, laryngologists, pulmonologists, and research scientists, the inaugural Gatherings in Esophagology (GiE) was held May 30–31, 2025, in France as a new initiative of Organisation mondiale d'Etudes Spécialisées pour les maladies de l'Oesophage (OESO).
Jennifer Cable, Robert Giuli, Mark R. Fox, Rachel L. Rosen, Luis R. Valdovinos‐García, Stefano Siboni, John O. Clarke, Nikki Johnston, Tina L. Samuels, Carmelo Scarpignato, Ellen M. Stein, Ronnie Fass, José María Remes‐Troches, Abraham Khan, Afrin Kamal Rahman, Kristle Lynch, Daniela Jodorkovsky, Marcelo F. Vela, Alexandra Vandenberg, Braden Kuo, Pelin Ergun, Sigh Pichamol Jirapinyo, Emanuele Asti, Salvatore Tolone, Eric G. Sheu, Renato Salvador, Marco Sozzi, Inna A. Husain, Justin C. Wu, Anthony Hobson, Nirmal S. Sharma, Wai‐Kit Lo, Daniel R. Duncan, C. Prakash Gyawali, Walter Chan, Daniel Sifrim, Edoardo Savarino, Nicola de Bortoli, Benjamin D. Rogers   +38 more
wiley   +1 more source

Curbing inappropriate C. difficile treatment in patients receiving concomitant laxatives

Antimicrobial Stewardship & Healthcare Epidemiology
In the setting of universal Clostridioides difficile screening, we implemented an alert that triggered when C. difficile treatment was ordered in patients who recently received laxatives. This resulted in C.
Paige Fields, Christopher David, Anish Choksi, Natasha N. Pettit, Alison K. Lew, Jennifer Pisano, Cynthia T. Nguyen   +6 more
doaj   +1 more source

Dominance of toxigenic Clostridioides difficile strains and the appearance of the emerging PCR ribotype 955 in hospitals in Silesia, Poland

Frontiers in Microbiology
IntroductionToxigenic strains of Clostridioides difficile are the leading cause of healthcare-associated bacterial infections in Poland. In the Silesian Voivodeship, with 4.5 million inhabitants, the incidence of C.
Klaudia Szarek, Natalia Frankowska, Natalia Frankowska, Monika Kabała, Wiep Klaas Smits, Dorota Wultańska, Piotr Lalowski, Hanna Pituch, Adam Iwanicki, Krzysztof Hinc, Céline Harmanus, Ingrid M. J. G. Sanders, Robert Wojtyczka, Tomasz J. Wąsik   +13 more
doaj   +1 more source

The presence of Clostridioides difficile in faeces before and after faecal microbiota transplantation and its relation with recurrent C. difficile infection and the gut microbiota in a Dutch cohort [PDF]

Objectives: The objectives of this study are to investigate the presence of Clostridioides difficile in faeces of patients with recurrent C. difficile infection (rCDI) before and after faecal microbiota transplantation (FMT) and to identify risk factors ...
, Berssenbrugge, Eric K L, Ducarmon, Quinten R, Goorhuis, Abraham, Groenewegen, Bas, Keller, Josbert J, Kovynev, Artemiy, Kuijper, Ed J, Sanders, Ingrid M J G, Smits, Wiep Klaas, Terveer, Elisabeth M, van den Berg, Alexander J, van Lingen, Emilie, van Nood, Els, van Prehn, Joffrey, Wiese, Maria   +15 more
core   +1 more source