Results 31 to 40 of about 24,553 (208)

Epidemiology of Clostridioides difficile Infections in Germany, 2010–2019: A Review from Four Public Databases

Infectious Diseases and Therapy, 2023
Introduction Clostridioides difficile infection (CDI) is a recognized global threat especially for vulnerable populations. It is of particular concern to healthcare providers as it is found in both hospital and community settings, with severe courses ...
Gordon Brestrich, Frederick J. Angulo, Fabian K. Berger, Christian Brösamle, Stefan Hagel, Andreas Leischker, Christoph Lübbert, Friederike Maechler, Sophie-Susann Merbecks, Nadia Minarovic, Jennifer C. Moïsi, Lutz von Müller, Phillip A. Reuken, Thomas Weinke, Holly Yu, Alexander Mellmann   +15 more
doaj   +1 more source

Prospective Review of Clostridioides difficile Testing Indications to Inform Local Laboratory Stewardship Initiatives

Infection Prevention in Practice, 2019
Summary: We conducted a prospective chart review to determine the prevalence of and reasons for inappropriate Clostridioides difficile test-ordering at a tertiary care hospital. Inappropriate orders accounted for 54% of all tests.
Noah Reich, Michael Payne, Azra Sharma, Sylvie Champagne, Marc G. Romney, Michelle Hinch, Victor Leung, Christopher F. Lowe   +7 more
doaj   +1 more source

Clostridioides difficile Enteritis Induced Anastomotic Rupture: A Case Report and Literature Review

Case Reports in Surgery, 2020
Background. A 76-year-old male patient who suffered small bowel anastomotic dehiscence believed to be a complication provoked by Clostridioides difficile enteritis. Case Presentation. The patient was a 76-year-old male who underwent small bowel resection
David R. Velez, Mentor Ahmeti
doaj   +1 more source

Uncovering the Harms of Treating Clostridioides difficile Colonization

mSphere, 2021
Patients with toxin-negative Clostridioides ...
Christopher R. Polage, Nicholas A. Turner   +1 more
doaj   +1 more source

Clostridioides difficile Flagella

International Journal of Molecular Sciences
Clostridioides difficile is an important pathogen for humans with a lead in nosocomial infection, but it is also more and more common in communities. Our knowledge of the pathology has historically been focused on the toxins produced by the bacteria that remain its major virulence factors.
Jean-Christophe Marvaud, Sylvie Bouttier, Johanna Saunier, Imad Kansau   +3 more
openaire   +2 more sources

Freeze-dried fecal samples are biologically active after long-lasting storage and suited to fecal microbiota transplantation in a preclinical murine model of Clostridioides difficile infection

Gut Microbes, 2020
Fecal microbiota transplantation is now recommended for treating recurrent forms of Clostridioides difficile infection. Recent studies have reported protocols using capsules of either frozen or freeze-dried stool allowing oral administration in in- and ...
Julie Reygner, Christine Charrueau, Johanne Delannoy, Camille Mayeur, Véronique Robert, Céline Cuinat, Thierry Meylheuc, Aurélie Mauras, Jérémy Augustin, Ioannis Nicolis, Morgane Modoux, Francisca Joly, Anne-Judith Waligora-Dupriet, Muriel Thomas, Nathalie Kapel   +14 more
doaj   +1 more source

The Bacterial Gut Microbiota of Adult Patients Infected, Colonized or Noncolonized by Clostridioides difficile

Microorganisms, 2020
Gut microbiota composition in patients with Clostridioides difficile colonization is not well investigated. We aimed to identify bacterial signatures associated with resistance and susceptibility to C.
Monique J. T. Crobach, Quinten R. Ducarmon, Elisabeth M. Terveer, Celine Harmanus, Ingrid M. J. G. Sanders, Kees M. Verduin, Ed J. Kuijper, Romy D. Zwittink   +7 more
doaj   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Randomized Controlled Trial of Oral Vancomycin Treatment in Clostridioides difficile-Colonized Patients

mSphere, 2021
A gold standard diagnostic for Clostridioides ...
Skye R. S. Fishbein, Tiffany Hink, Kimberly A. Reske, Candice Cass, Emily Struttmann, Zainab Hassan Iqbal, Sondra Seiler, Jennie H. Kwon, Carey-Ann D. Burnham, Gautam Dantas, Erik R. Dubberke   +10 more
doaj   +1 more source

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source