Results 1 to 10 of about 18,045 (186)

Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin. [PDF]

Int J Mol Sci, 2022
Clostridium perfringens type D epsilon toxin (ETX) produces severe, and frequently fatal, neurologic disease in ruminant livestock. The disorder is of worldwide distribution and, although vaccination has reduced its prevalence, ETX still causes substantial economic loss in livestock enterprises.
Finnie JW, Uzal FA.
europepmc   +5 more sources

Reevaluation of whether a Functional Agr-like Quorum-Sensing System Is Necessary for Production of Wild-Type Levels of Epsilon-Toxin by Clostridium perfringens Type D Strains [PDF]

mBio, 2022
Clostridium perfringens type B and D strains produce epsilon-toxin (ETX). Our 2011 mBio study (mBio 2:e00275-11, 2011, https://doi.org/10.1128/mBio.00275-11) reported that the Agr quorum-sensing (QS) system regulates ETX production by type D strain ...
Iman Mehdizadeh Gohari, Jihong Li, Julian I. Rood, Bruce A. McClane   +3 more
doaj   +2 more sources

Outbreak of Clostridium perfringens type D enterotoxemia in sheep

Semina: Ciências Agrárias, 2019
This work describes the first Brazilian laboratory-confirmed outbreak of enterotoxemia caused by Clostridium perfringens type D in sheep, which occurred in the state of Paraná.
Felipe Masiero Salvarani, Mayane Faccin, Nayra Fernanda de Queiroz Ramos Freitas, Mônica Regina de Matos, Edismair Carvalho Garcia, Geane Maciel Pagliosa, José Diomedes Barbosa, Francisco Carlos Faria Lobato, Aline de Marco Viott   +8 more
doaj   +3 more sources

Design of a chitosan-based nano vaccine against epsilon toxin of Clostridium perfringens type D and evaluation of its immunogenicity in BALB/c mice [PDF]

Research in Pharmaceutical Sciences, 2021
Background and purpose: Clostridium perfringens is an anaerobic, spore-forming, and pathogenic bacterium that causes intestinal diseases in humans and animals.
Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi   +4 more
doaj   +2 more sources

Mapping of the continuous epitopes displayed on the Clostridium perfringens type D epsilon-toxin. [PDF]

Braz J Microbiol, 2017
The epsilon toxin, produced by Clostridium perfringens, is responsible for enterotoxemia in ruminants and is a potential bioterrorism agent. In the present study, 15 regions of the toxin were recognized by antibodies present in the serum, with different immunodominance scales, and may be antigen determinants that can be used to formulate subunit ...
Alves GG, Machado-de-Ávila RA, Chávez-Olórtegui CD, Silva ROS, Lobato FCF.   +4 more
europepmc   +5 more sources

In silico vaccine design: Targeting highly epitopic regions of Clostridium perfringens type D epsilon toxin and Clostridium novyi type B alpha toxin for optimal immunogenicity [PDF]

Computational and Structural Biotechnology Journal
Livestock infections caused by highly toxic bacteria, such as Clostridium perfringens type D and Clostridium novyi type B, present significant challenges in veterinary medicine.
Nastaran Ashoori, Mohammad Mehdi Ranjbar, Romana Schirhagl   +2 more
doaj   +2 more sources

Effect of Clostridium perfringens type D toxin on Caenorhabditis elegans

NAM Journal
The search for an alternative in vivo diagnostic method for Clostridium perfringens toxinotype D (CPD) aimed to evaluate the susceptibility of the nematode Caenorhabditis elegans CF512 CPD as a substitute for conventional biological models.
Ana María Delia Pereyra, Ximena Blanco Crivelli, Mariana Sanin, Adriana Bentancor, Cecilia Cundon   +4 more
doaj   +2 more sources

Production and purification of epsilon prototoxin produced by Clostridium perfringens type D

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2002
A prototoxina epsilon foi obtida a partir de cultivo liquido, rico em carboidratos, a partir de amostra de C. perfringens tipo D (INTA - Argentina), incubado em condicoes de anarobiose a 37oC por oito horas. O sobrenadante da cultura foi concentrado utilizando-se o sistema Amicon com membrana de "cut off" de 10 kDa.
P.M. Parreiras, F.C.F. Lobato, C.F.L.G.D. Heneine, R.A. Assis, G.M. Balsamão, R.A.P. Nascimento   +5 more
doaj   +4 more sources

Prevalence of Clostridium perfringens infection and virulence genes molecular study in broiler chickens [PDF]

Benha Veterinary Medical Journal, 2020
Clostridium perfringens (C. perfringens) produces toxins that cause necrotic enteritis (NE) in broiler chickens resulting in sever losses in poultry industry. This study aimed to investigate the prevalence of C.
Shreen Mayouf, Mohammed El- Bardisy, Ashraf Abd El-Tawab, Amira Rizk   +3 more
doaj   +1 more source

Molecular Typing of Clostridium perfringens Isolates from Soil, Healthy, and Diseased Sheep in Egypt by Multiplex PCR [PDF]

Journal of Veterinary Medical Research, 2013
In this study multiplex PCR was used for typing of Clostridium perfringens isolates from soil, clinically healthy and diseased sheep. Clostridium perfringens was isolated from 41 out of 100 soil samples, 12 out of 100 clinically healthy sheep and 118 out
M. Nayel, A. El-Sify, S. Akram, M. Allaam, E. Abdeen, H. Hassan   +5 more
doaj   +1 more source