Results 1 to 10 of about 34,368 (213)

Reevaluation of whether a Functional Agr-like Quorum-Sensing System Is Necessary for Production of Wild-Type Levels of Epsilon-Toxin by Clostridium perfringens Type D Strains [PDF]

mBio, 2022
Clostridium perfringens type B and D strains produce epsilon-toxin (ETX). Our 2011 mBio study (mBio 2:e00275-11, 2011, https://doi.org/10.1128/mBio.00275-11) reported that the Agr quorum-sensing (QS) system regulates ETX production by type D strain ...
Iman Mehdizadeh Gohari, Jihong Li, Julian I. Rood, Bruce A. McClane   +3 more
doaj   +2 more sources

Design of a chitosan-based nano vaccine against epsilon toxin of Clostridium perfringens type D and evaluation of its immunogenicity in BALB/c mice [PDF]

Research in Pharmaceutical Sciences, 2021
Background and purpose: Clostridium perfringens is an anaerobic, spore-forming, and pathogenic bacterium that causes intestinal diseases in humans and animals.
Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi   +4 more
doaj   +2 more sources

Outbreak of Clostridium perfringens type D enterotoxemia in sheep

Semina: Ciências Agrárias, 2019
This work describes the first Brazilian laboratory-confirmed outbreak of enterotoxemia caused by Clostridium perfringens type D in sheep, which occurred in the state of Paraná.
Felipe Masiero Salvarani, Mayane Faccin, Nayra Fernanda de Queiroz Ramos Freitas, Mônica Regina de Matos, Edismair Carvalho Garcia, Geane Maciel Pagliosa, José Diomedes Barbosa, Francisco Carlos Faria Lobato, Aline de Marco Viott   +8 more
doaj   +3 more sources

In silico vaccine design: Targeting highly epitopic regions of Clostridium perfringens type D epsilon toxin and Clostridium novyi type B alpha toxin for optimal immunogenicity [PDF]

Computational and Structural Biotechnology Journal
Livestock infections caused by highly toxic bacteria, such as Clostridium perfringens type D and Clostridium novyi type B, present significant challenges in veterinary medicine.
Nastaran Ashoori, Mohammad Mehdi Ranjbar, Romana Schirhagl   +2 more
doaj   +2 more sources

Mapping of the continuous epitopes displayed on the Clostridium perfringens type D epsilon-toxin. [PDF]

Braz J Microbiol, 2017
The epsilon toxin, produced by Clostridium perfringens, is responsible for enterotoxemia in ruminants and is a potential bioterrorism agent. In the present study, 15 regions of the toxin were recognized by antibodies present in the serum, with different immunodominance scales, and may be antigen determinants that can be used to formulate subunit ...
Alves GG, Machado-de-Ávila RA, Chávez-Olórtegui CD, Silva ROS, Lobato FCF.   +4 more
europepmc   +5 more sources

Immunoprophylactic strategies against enterotoxemia caused by Clostridium perfringens type D in goats Estratégias imunoprofiláticas contra enterotoxemia causada por Clostridium perfringens tipo D em caprinos [PDF]

Pesquisa Veterinária Brasileira, 2006
The serological response to an experimental vaccine against Clostridium perfringens type D enterotoxemia was evaluated in four groups of goats. Group 1 received colostrum from unvaccinated cows and no vaccine.
Josir Laine A. Veschi, Iveraldo S. Dutra, Mariano E. Fernandez Miyakawa, Silvia Helena V. Perri, Francisco A. Uzal   +4 more
doaj   +6 more sources

Effect of Clostridium perfringens type D toxin on Caenorhabditis elegans

NAM Journal
The search for an alternative in vivo diagnostic method for Clostridium perfringens toxinotype D (CPD) aimed to evaluate the susceptibility of the nematode Caenorhabditis elegans CF512 CPD as a substitute for conventional biological models.
Ana María Delia Pereyra, Ximena Blanco Crivelli, Mariana Sanin, Adriana Bentancor, Cecilia Cundon   +4 more
doaj   +2 more sources

Stability and toxicity of Clostridium perfringens type D epsilon prototoxin treated by iodine Estabilidade e toxicidade da protoxina epsilon de Clostridium perfringens tipo D

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2008
Purified epsilon prototoxin of Clostridium perfringens type D was produced, purified, and detoxified by the stoiechiometric method of non-radioactive iodine incorporation.
P.H. Rocha, R.A. Assis, F.C.F. Lobato, V.N. Cardoso, L.G.D. Heneine   +4 more
doaj   +2 more sources

Production and purification of epsilon prototoxin produced by Clostridium perfringens type D

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2002
A prototoxina epsilon foi obtida a partir de cultivo liquido, rico em carboidratos, a partir de amostra de C. perfringens tipo D (INTA - Argentina), incubado em condicoes de anarobiose a 37oC por oito horas. O sobrenadante da cultura foi concentrado utilizando-se o sistema Amicon com membrana de "cut off" de 10 kDa.
P.M. Parreiras, F.C.F. Lobato, C.F.L.G.D. Heneine, R.A. Assis, G.M. Balsamão, R.A.P. Nascimento   +5 more
doaj   +4 more sources

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
core   +18 more sources