The pore structure of Clostridium perfringens epsilon toxin [PDF]
Nature Communications, 2019 Epsilon toxin (Etx) is a potent pore forming toxin (PFT) produced by Clostridium perfringens. Here authors show the cryo-EM structure of the Etx pore assembled on the membrane of susceptible cells and shed light on pore formation and mutant phenotypes.
Christos G. Savva +7 more
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Multiple Sclerosis and Clostridium perfringens Epsilon Toxin: Is There a Relationship? [PDF]
BiomedicinesRecent research has suggested a link between multiple sclerosis and the gut microbiota. This prospective pilot study aimed to investigate the composition of the gut microbiota in MS patients, the presence of Clostridium perfringens epsilon toxin in the ...
André Huss +4 more
doaj +3 more sources
Is Clostridium perfringens epsilon toxin associated with multiple sclerosis? [PDF]
Mult Scler, 2023 Clostridium perfringens epsilon toxin is associated with enterotoxaemia in livestock. More recently, it is proposed to play a role in multiple sclerosis (MS) in humans. Compared to matched controls, strains of C.
Titball RW, Lewis N, Nicholas R.
europepmc +4 more sources
Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes [PDF]
Toxins, 2023 Clostridium perfringens epsilon toxin (ETX) is the third most lethal bacterial toxin and has been suggested to be an environmental trigger of multiple sclerosis, an immune-mediated disease of the human central nervous system. However, ETX cytotoxicity on
Samantha V. Shetty +7 more
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Cell death analysis of recombinant mature epsilon toxin on the kidney cell line [PDF]
Iranian Journal of Microbiology, 2021 Background and Objectives: Epsilon toxin is the third hazardous bacterial toxin causing ABS enterotoxaemia in domestic animal. In addition, epsilon toxin is known as a biological warfare agent.
Roza Chehreara +6 more
doaj +3 more sources
Design of a chitosan-based nano vaccine against epsilon toxin of Clostridium perfringens type D and evaluation of its immunogenicity in BALB/c mice [PDF]
Research in Pharmaceutical Sciences, 2021 Background and purpose: Clostridium perfringens is an anaerobic, spore-forming, and pathogenic bacterium that causes intestinal diseases in humans and animals.
Farnaz Poorhassan +4 more
doaj +3 more sources
New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity [PDF]
Toxins, 2022 Epsilon toxin (Etx) from Clostridium perfringens is the third most potent toxin after the botulinum and tetanus toxins. Etx is the main agent of enterotoxemia in ruminants and is produced by Clostridium perfringens toxinotypes B and D, causing great ...
Jonatan Dorca-Arévalo +2 more
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Reevaluation of whether a Functional Agr-like Quorum-Sensing System Is Necessary for Production of Wild-Type Levels of Epsilon-Toxin by Clostridium perfringens Type D Strains [PDF]
mBio, 2022 Clostridium perfringens type B and D strains produce epsilon-toxin (ETX). Our 2011 mBio study (mBio 2:e00275-11, 2011, https://doi.org/10.1128/mBio.00275-11) reported that the Agr quorum-sensing (QS) system regulates ETX production by type D strain ...
Iman Mehdizadeh Gohari +3 more
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Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of Clostridium perfringens Epsilon Toxin in MDCK Cells [PDF]
ToxinsEpsilon toxin (ETX), a potential agent of biological and toxic warfare, causes the death of many ruminants and threatens human health. It is crucial to understand the toxic mechanism of such a highly lethal and rapid course toxin.
Nan Yue +16 more
doaj +3 more sources
Clostridium epsilon toxin is excessive in multiple sclerosis and provokes multifocal lesions in mouse models [PDF]
The Journal of Clinical Investigation, 2023 Multiple sclerosis (MS) is an inflammatory disease of the CNS. In this issue of the JCI, Ma and Sannino et al. show that two strains of intestinal Clostridium perfringens, known to produce epsilon toxin (ETX), were frequently found in patients with MS ...
Anthony T. Reder
doaj +3 more sources