Results 31 to 40 of about 396,299 (201)

In vivo Blood-brain Barrier Permeability Assays Using Clostridium perfringens Epsilon Toxin [PDF]

Bio-Protocol, 2020
In order for the brain to function properly, a carefully orchestrated homeostasis must be maintained. To help regulate this delicate balance, the brain has developed a highly selective blood-brain barrier (BBB).
Michael Mazzucco, Timothy Vartanian, Jennifer Linden   +2 more
doaj   +2 more sources

Clostridium Perfringens Epsilon Toxin Binds to Membrane Lipids and Its Cytotoxic Action Depends on Sulfatide. [PDF]

PLoS ONE, 2015
Epsilon toxin (Etx) is one of the major lethal toxins produced by Clostridium perfringens types B and D, being the causal agent of fatal enterotoxemia in animals, mainly sheep and goats.
Carles Gil, Jonatan Dorca-Arévalo, Juan Blasi   +2 more
doaj   +6 more sources

Direct Visualization of the Dynamic Process of Epsilon Toxin on Hemolysis

Small Methods, 2023
Hemolysis is the process of rupturing erythrocytes (red blood cells) by forming nanopores on their membranes using hemolysins, which then impede membrane permeability.
Bin Ji, Jianxiang Huang, Kexuan Zou, M. Liu, Yufeng Pei, Jing Huang, Yong Wang, Jinglin Wang, Ruhong Zhou, Wenwen Xin, Jie Song   +10 more
semanticscholar   +3 more sources

Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives. [PDF]

Int J Pharm, 2017
Clostridium perfringens epsilon toxin (ETX) is considered as one of the most dangerous potential biological weapons. The goal of this work was to identify inhibitors of ETX using a novel approach for the inactivation of pore-forming toxins. The approach is based on the blocking of the target pore with molecules having the same symmetry as the pore ...
Robinson TM, Jicsinszky L, Karginov AV, Karginov VA.   +3 more
europepmc   +4 more sources

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis. [PDF]

Mult Scler, 2019
Background: It was recently reported that, using Western blotting, some multiple sclerosis (MS) patients in the United States had antibodies against epsilon toxin (Etx) from Clostridium perfringens, suggesting that the toxin may play a role in the disease.
Wagley S, Bokori-Brown M, Morcrette H, Malaspina A, D'Arcy C, Gnanapavan S, Lewis N, Popoff MR, Raciborska D, Nicholas R, Turner B, Titball RW.   +11 more
europepmc   +6 more sources

A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization [PDF]

Antibodies, 2018
The pore-forming epsilon toxin (ETX) produced by Clostridium perfringens is among the most lethal bacterial toxins known. Sensitive antibody-based reagents are needed to detect toxin, distinguish mechanisms of cell death, and prevent ETX toxicity.
Jennifer R. Linden, Kiel Telesford, Samantha Shetty, Paige Winokour, Sylvia Haigh, Ellen Cahir-McFarland, Giovanna Antognetti, Abhishek Datta, Tao Wang, Werner Meier, Timothy Vartanian   +10 more
doaj   +2 more sources

Cloning and Expression of a Fusion Protein Containing Highly Epitopic Regions of Clostridium perfringens Epsilon Toxin and Clostridium novyi Alpha Toxin [PDF]

Journal of Cell and Molecular Research, 2021
Clostridium perfringens and novyi species are two important toxin-producing pathogens which pose a risk to the livestock health. Epsilon and alpha toxins are major toxins of these two pathogens, respectively. Advances in current vaccine industrialization
Mohsen Mehrvarz, Mohsen Fathi Najafi, Taghi Zahraei Salehi, Behjat Majidi   +3 more
doaj   +1 more source

Molecular characterization and toxins optimization of indigenous clostridium perfringens toxinotype b isolated from lamb dysentery clinical cases [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2023
Clostridium perfringens toxinotype B is causative agent of lamb dysentery in Pakistan. For assessment of gene expression, it is preferred to optimize toxin production potential of indigenous isolates.
Mian Muhammad Khubaib SATTAR, Aftab Ahmad ANJUM, ung Fu CHANG, Tahir YAQUB, Asim ASLAM, Tehreem ALI   +5 more
doaj   +1 more source

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
core   +21 more sources

Clostridium perfringens epsilon toxin increases the small intestinal permeability in mice and rats. [PDF]

PLoS ONE, 2009
Epsilon toxin is a potent neurotoxin produced by Clostridium perfringens types B and D, an anaerobic bacterium that causes enterotoxaemia in ruminants.
Jorge Goldstein, Winston E Morris, César Fabián Loidl, Carla Tironi-Farinati, Bruce A McClane, Francisco A Uzal, Mariano E Fernandez Miyakawa   +6 more
doaj   +1 more source