Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens [PDF]
Veterinary Research, 2020 The pore-forming protein epsilon toxin (Etx) from Clostridium perfringens produces acute perivascular edema affecting several organs, especially the brain and lungs.
Jonatan Dorca-Arévalo +5 more
doaj +7 more sources
A small bioactive glycoside inhibits epsilon toxin and prevents cell death [PDF]
Disease Models & Mechanisms, 2019 Clostridium perfringens epsilon toxin (Etx) is categorized as the third most lethal bioterrorism agent by the Centers for Disease Control and Prevention (CDC), with no therapeutic counter measures available for humans.
Abhishek Shivappagowdar +11 more
doaj +4 more sources
Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege. [PDF]
J Clin Invest, 2023 Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown.
Ma Y +32 more
europepmc +2 more sources
Clostridium perfringens Type D Epsilon Toxin Causes Blood-Retinal Barrier Microvascular Damage and Diffuse Retinal Vasogenic Oedema. [PDF]
Vet Sci, 2023 Simple Summary The bacterium Clostridium perfringens type D produces a potent epsilon toxin (ETX), which causes severe, and frequently fatal, neurologic disease in sheep and goats.
Finnie JW.
europepmc +2 more sources
Evaluation of humoral immune responses against C. perfringens epsilon toxin in Iranian sheep and goats after vaccination. [PDF]
Vet Anim Sci, 2023 Highlights • Evaluate the humoral immune responses using iELISA in sheep and goats.• Sheep antibody titer was observed higher than goats.• The duration of humoral immune response of goats against the clostridial vaccine was short.• The antibody titer in ...
Asadi A, Khiav LA, Emadi A, Dadar M.
europepmc +2 more sources
Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin. [PDF]
Int J Mol Sci, 2022 Clostridium perfringens type D epsilon toxin (ETX) produces severe, and frequently fatal, neurologic disease in ruminant livestock. The disorder is of worldwide distribution and, although vaccination has reduced its prevalence, ETX still causes ...
Finnie JW, Uzal FA.
europepmc +2 more sources
Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis? [PDF]
Toxins (Basel)Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder, characterized by progressive demyelination and neuronal cell loss in the central nervous system.
Gougeon ML +4 more
europepmc +2 more sources
Clostridium perfringens Epsilon-Toxin Impairs the Barrier Function in MDCK Cell Monolayers in a Ca2+-Dependent Manner [PDF]
Toxins, 2020 Epsilon-toxin produced by Clostridium perfringens significantly contributes to the pathogeneses of enterotoxemia in ruminants and multiple sclerosis in humans. Epsilon-toxin forms a heptameric oligomer in the host cell membrane, promoting cell disruption.
Masahiro Nagahama +4 more
doaj +2 more sources
The epsilon toxin from Clostridium perfringens stimulates calcium-activated chloride channels, generating extracellular vesicles in Xenopus oocytes. [PDF]
Pharmacol Res PerspectThe epsilon toxin (Etx) from Clostridium perfringens has been identified as a potential trigger of multiple sclerosis, functioning as a pore‐forming toxin that selectively targets cells expressing the plasma membrane (PM) myelin and lymphocyte protein ...
Cases M +8 more
europepmc +2 more sources
Screening and Identification of DNA Nanostructure Aptamer Using the SELEX Method for Detection of Epsilon Toxin [PDF]
Iran J Pharm Res, 2023 Background Epsilon toxin (ETX), produced by Clostridium perfringens, is one of the most potent toxins known, with a lethal potency approaching that of botulinum neurotoxins. Epsilon toxin is responsible for enteritis.
Shafiei N +4 more
europepmc +2 more sources