The pore structure of Clostridium perfringens epsilon toxin [PDF]
Nature Communications, 2019 Epsilon toxin (Etx) is a potent pore forming toxin (PFT) produced by Clostridium perfringens. Here authors show the cryo-EM structure of the Etx pore assembled on the membrane of susceptible cells and shed light on pore formation and mutant phenotypes.
Christos G. Savva +7 more
doaj +9 more sources
Multiple Sclerosis and Clostridium perfringens Epsilon Toxin: Is There a Relationship? [PDF]
BiomedicinesRecent research has suggested a link between multiple sclerosis and the gut microbiota. This prospective pilot study aimed to investigate the composition of the gut microbiota in MS patients, the presence of Clostridium perfringens epsilon toxin in the ...
André Huss +4 more
doaj +6 more sources
Clostridium perfringens Epsilon Toxin: A Malevolent Molecule for Animals and Man? [PDF]
Toxins, 2013 Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens (types B and D) that induces fatal enteric disease of ...
Michel R. Popoff +3 more
doaj +4 more sources
Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis [PDF]
Multiple Sclerosis Journal, 2019 Background: It was recently reported that, using Western blotting, some multiple sclerosis (MS) patients in the United States had antibodies against epsilon toxin (Etx) from Clostridium perfringens, suggesting that the toxin may play a role in the disease.
Monika Bokori-Brown +2 more
exaly +7 more sources
Cell death analysis of recombinant mature epsilon toxin on the kidney cell line [PDF]
Iranian Journal of Microbiology, 2021 Background and Objectives: Epsilon toxin is the third hazardous bacterial toxin causing ABS enterotoxaemia in domestic animal. In addition, epsilon toxin is known as a biological warfare agent.
Roza Chehreara +6 more
doaj +2 more sources
Design of a chitosan-based nano vaccine against epsilon toxin of Clostridium perfringens type D and evaluation of its immunogenicity in BALB/c mice [PDF]
Research in Pharmaceutical Sciences, 2021 Background and purpose: Clostridium perfringens is an anaerobic, spore-forming, and pathogenic bacterium that causes intestinal diseases in humans and animals.
Farnaz Poorhassan +4 more
doaj +2 more sources
Is Clostridium perfringens epsilon toxin associated with multiple sclerosis? [PDF]
Mult Scler, 2023 Clostridium perfringens epsilon toxin is associated with enterotoxaemia in livestock. More recently, it is proposed to play a role in multiple sclerosis (MS) in humans. Compared to matched controls, strains of C. perfringens which produce epsilon toxin are significantly more likely to be isolated from the gut of MS patients and at significantly higher ...
Titball RW, Lewis N, Nicholas R.
europepmc +3 more sources
Clostridium perfringens Epsilon-Toxin Impairs the Barrier Function in MDCK Cell Monolayers in a Ca2+-Dependent Manner [PDF]
Toxins, 2020 Epsilon-toxin produced by Clostridium perfringens significantly contributes to the pathogeneses of enterotoxemia in ruminants and multiple sclerosis in humans. Epsilon-toxin forms a heptameric oligomer in the host cell membrane, promoting cell disruption.
Masahiro Nagahama +4 more
doaj +2 more sources
Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes [PDF]
Toxins, 2023 Clostridium perfringens epsilon toxin (ETX) is the third most lethal bacterial toxin and has been suggested to be an environmental trigger of multiple sclerosis, an immune-mediated disease of the human central nervous system. However, ETX cytotoxicity on
Samantha V. Shetty +7 more
doaj +2 more sources
Reevaluation of whether a Functional Agr-like Quorum-Sensing System Is Necessary for Production of Wild-Type Levels of Epsilon-Toxin by Clostridium perfringens Type D Strains [PDF]
mBio, 2022 Clostridium perfringens type B and D strains produce epsilon-toxin (ETX). Our 2011 mBio study (mBio 2:e00275-11, 2011, https://doi.org/10.1128/mBio.00275-11) reported that the Agr quorum-sensing (QS) system regulates ETX production by type D strain ...
Iman Mehdizadeh Gohari +3 more
doaj +2 more sources