Results 21 to 30 of about 396,299 (201)

Interaction of Clostridium perfringens Epsilon Toxin with the Plasma Membrane: The Role of Amino Acids Y42, Y43 and H162. [PDF]

Toxins (Basel), 2022
Clostridium perfringens epsilon toxin (Etx) is a pore forming toxin that causes enterotoxaemia in ruminants and may be a cause of multiple sclerosis in humans. To date, most in vitro studies of Etx have used the Madin-Darby canine kidney (MDCK) cell line.
Marshall S, McGill B, Morcrette H, Winlove CP, Chimerel C, Petrov PG, Bokori-Brown M.   +6 more
europepmc   +2 more sources

Prevalence of epsilon toxin-producing Clostridium perfringens isolates among patients with multiple sclerosis and neuromyelitis optica spectrum disorder in Iran. [PDF]

BMC Neurol
Clostridium perfringens epsilon toxin (ETX) is a potent neurotoxin that crosses the blood-brain barrier (BBB), and has been suggested to be involved in demyelinating CNS disorders. Here, we investigated the prevalence of C.
Azimirad M, Hamtaeigashti S, Raeisi H, Looha MA, Gholami F, Naser Moghadasi A, Zali MR, Yadegar A.   +7 more
europepmc   +2 more sources

Recombinant unpurified rETX^H106P/ CTB-rETX^Y196E protects rabbits against Clostridium perfringens epsilon toxin. [PDF]

J Vet Med Sci, 2021
Epsilon toxin (ETX), produced by Clostridium perfringens types B and D, has been touted as a potential biological weapon and is known to induce fatal enterotoxemia in a variety of livestock animals.
Peng X, Li X, Peng G, Feng L, Jiang Y, Luo Y.   +5 more
europepmc   +2 more sources

In silico vaccine design: Targeting highly epitopic regions of Clostridium perfringens type D epsilon toxin and Clostridium novyi type B alpha toxin for optimal immunogenicity. [PDF]

Comput Struct Biotechnol J
Livestock infections caused by highly toxic bacteria pose significant challenges in veterinary medicine, often requiring complex and elusive treatment regimens.
Ashoori N, Ranjbar MM, Schirhagl R.
europepmc   +2 more sources

Epsilon Toxin from <i>Clostridium perfringens</i> Induces the Generation of Extracellular Vesicles in HeLa Cells Overexpressing Myelin and Lymphocyte Protein. [PDF]

Toxins (Basel)
Epsilon toxin (ETX) from Clostridium perfringens is a pore-forming toxin (PFT) that crosses the blood–brain barrier and binds to myelin structures. In in vitro assays, ETX causes oligodendrocyte impairment, subsequently leading to demyelination. In fact,
Dorca-Arévalo J, Santana-Ruiz A, Torrejón-Escribano B, Martín-Satué M, Blasi J.   +4 more
europepmc   +2 more sources

Highly sensitive sandwich immunoassay and immunochromatographic test for the detection of Clostridial epsilon toxin in complex matrices. [PDF]

PLoS ONE, 2017
Epsilon toxin is one of the four major toxins of Clostridium perfringens. It is the third most potent clostridial toxin after botulinum and tetanus toxins and is thus considered as a potential biological weapon classified as category B by the Centers for
Cécile Féraudet-Tarisse, Christelle Mazuet, Serge Pauillac, Maren Krüger, Caroline Lacroux, Michel R Popoff, Brigitte G Dorner, Olivier Andréoletti, Marc Plaisance, Hervé Volland, Stéphanie Simon   +10 more
doaj   +2 more sources

Immunization with recombinant fusion of LTB and linear epitope (40–62) of epsilon toxin elicits protective immune response against the epsilon toxin of Clostridium perfringens type D [PDF]

AMB Express, 2019
Epsilon toxin (Etx) produced by Clostridium perfringens types B and D, a major causative agent of enterotoxaemia causes significant economic losses to animal industry.
Himani Kaushik, Sachin Kumar Deshmukh, Amit Kumar Solanki, Bharti Bhatia, Archana Tiwari, Lalit C. Garg   +5 more
doaj   +2 more sources

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

PLoS Pathog, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Linden JR, Flores C, Schmidt EF, Uzal FA, Michel AO, Valenzuela M, Dobrow S, Vartanian T.   +7 more
europepmc   +3 more sources

Proteolytic processing and activation of Clostridium perfringens epsilon toxin by caprine small intestinal contents. [PDF]

mBio, 2014
Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease.
Freedman JC, Li J, Uzal FA, McClane BA.
europepmc   +4 more sources

Clostridium perfringens Epsilon Toxin: A Malevolent Molecule for Animals and Man? [PDF]

Toxins, 2013
Clostridium perfringens is a prolific, toxin-producing anaerobe causing multiple diseases in humans and animals. One of these toxins is epsilon, a 33 kDa protein produced by Clostridium perfringens (types B and D) that induces fatal enteric disease of ...
Michel R. Popoff, Holger Barth, Gillian Barth, Bradley G. Stiles   +3 more
doaj   +2 more sources