New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity [PDF]
Toxins, 2022 Epsilon toxin (Etx) from Clostridium perfringens is the third most potent toxin after the botulinum and tetanus toxins. Etx is the main agent of enterotoxemia in ruminants and is produced by Clostridium perfringens toxinotypes B and D, causing great ...
Jonatan Dorca-Arévalo +2 more
doaj +2 more sources
Highly sensitive sandwich immunoassay and immunochromatographic test for the detection of Clostridial epsilon toxin in complex matrices. [PDF]
PLoS ONE, 2017 Epsilon toxin is one of the four major toxins of Clostridium perfringens. It is the third most potent clostridial toxin after botulinum and tetanus toxins and is thus considered as a potential biological weapon classified as category B by the Centers for
Cécile Féraudet-Tarisse +10 more
doaj +2 more sources
Histidine residues in Clostridium perfringens epsilon toxin [PDF]
FEMS Microbiology Letters, 1987 Clostridium perfringens epsilon toxin was inactivated by ethoxyformic anhydride. A histidyl residue in the toxin was carbethoxylated under the conditions in which the toxin was completely inactivated, whereas tyrosyl residues were not affected. The toxin inactivated by ethoxyformic anhydride (EFA) was reactivated by treatment with hydroxylamine.
Jun Sakurai +2 more
exaly +3 more sources
Immunization with recombinant fusion of LTB and linear epitope (40–62) of epsilon toxin elicits protective immune response against the epsilon toxin of Clostridium perfringens type D [PDF]
AMB Express, 2019 Epsilon toxin (Etx) produced by Clostridium perfringens types B and D, a major causative agent of enterotoxaemia causes significant economic losses to animal industry.
Himani Kaushik +5 more
doaj +2 more sources
Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens [PDF]
Veterinary Research, 2020 The pore-forming protein epsilon toxin (Etx) from Clostridium perfringens produces acute perivascular edema affecting several organs, especially the brain and lungs.
Jonatan Dorca-Arévalo +5 more
doaj +2 more sources
Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of Clostridium perfringens Epsilon Toxin in MDCK Cells [PDF]
ToxinsEpsilon toxin (ETX), a potential agent of biological and toxic warfare, causes the death of many ruminants and threatens human health. It is crucial to understand the toxic mechanism of such a highly lethal and rapid course toxin.
Nan Yue +16 more
doaj +2 more sources
In vivo Blood-brain Barrier Permeability Assays Using Clostridium perfringens Epsilon Toxin [PDF]
Bio-Protocol, 2020 In order for the brain to function properly, a carefully orchestrated homeostasis must be maintained. To help regulate this delicate balance, the brain has developed a highly selective blood-brain barrier (BBB).
Michael Mazzucco +2 more
doaj +2 more sources
A small bioactive glycoside inhibits epsilon toxin and prevents cell death [PDF]
Disease Models & Mechanisms, 2019 Clostridium perfringens epsilon toxin (Etx) is categorized as the third most lethal bioterrorism agent by the Centers for Disease Control and Prevention (CDC), with no therapeutic counter measures available for humans.
Abhishek Shivappagowdar +11 more
doaj +2 more sources
Inhibition of Clostridium perfringens epsilon toxin by β-cyclodextrin derivatives. [PDF]
Int J Pharm, 2017 Clostridium perfringens epsilon toxin (ETX) is considered as one of the most dangerous potential biological weapons. The goal of this work was to identify inhibitors of ETX using a novel approach for the inactivation of pore-forming toxins. The approach is based on the blocking of the target pore with molecules having the same symmetry as the pore ...
Robinson TM +3 more
europepmc +4 more sources
Clostridium perfringens epsilon toxin inhibits the gastrointestinal transit in mice
Research in Veterinary Science, 2010 Epsilon toxin produced by Clostridium perfringens type B and D is a potent toxin that is responsible for a highly fatal enterotoxemia in sheep and goats. In vitro, epsilon toxin produces contraction of the rat ileum as the result of an indirect action, presumably mediated through the autonomic nervous system.
Mariano E Fernández-Miyakawa
exaly +4 more sources