Results 91 to 100 of about 42,559 (244)

Antipsychotic Use Among Intellectually Disabled Individuals With Rare Genetic Variants That Confer Risk for Schizophrenia

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Rare genetic variation can predispose individuals to the development of schizophrenia, with certain genes and copy number variants (CNVs) conferring risk at the exome/genome‐wide level. Despite this strong association, little is known about antipsychotic effectiveness and tolerability among individuals with most of these disorders ...
Mark Ainsley Colijn
wiley   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, EarlyView.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Efficacy of a Transdiagnostic Sleep and Circadian Intervention for Outpatients With Sleep Problems and Depression, Attention Deficit Disorder, or Bipolar Disorder: A Randomised Controlled Trial

Journal of Sleep Research, EarlyView.
ABSTRACT This study aimed to investigate the efficacy of a Danish adaption of a transdiagnostic sleep and circadian intervention, combining cognitive behavioural therapy for insomnia with chronotherapy. A randomised controlled trial enrolling 88 outpatients with depression, attention deficit disorder, or bipolar disorder suffering from insomnia or ...
Mette Kragh, Henny Dyrberg, Sanne Toft Kristiansen, Maria Speed, Pernille Pedersen, Klaus Martiny   +5 more
wiley   +1 more source

The experience of body image in people with psychosis and psychotic‐like experiences: A co‐produced mixed‐methods systematic review and narrative synthesis

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Purpose Body image is a transdiagnostic construct that seems poorly understood in psychosis. Poor body image is associated with paranoia, which makes it a theoretically meaningful treatment target in psychosis. We systematically reviewed associations between body image and psychosis symptoms in both the ‘general’ population and people living ...
Jenna McAllister, Sophie M. Allan, Alie Phiri, Kara Keddie, Tracey McKee, Leonie Richardson, Felicity Waite, Rebekah Carney, Gillian MacAfee, Andrew Gumley, Stephanie Allan   +10 more
wiley   +1 more source

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. [PDF]

, 1994
Leif Bertilsson, JA Carrillo, M-L Dahl, Adrián LLerena, C. Alm, Ulf Bondesson, L. Lindström, I Rodriguez de la Rubia, Sara Ramos, J. Benítez   +9 more
openalex   +1 more source

Ensuring generalizability and clinical utility in mental health care applications: Robust artificial intelligence‐based treatment predictions in diverse psychosis populations

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Artificial Intelligence (AI)‐based prediction models of treatment response promise to revolutionize psychiatric care by enabling personalized treatment, but very few have been thoroughly tested in different samples or compared to current clinical standards.
Fiona Coutts, Sergio Mena, Esin Ucur, W Wolfgang Fleischhacker, Rene Kahn, Jeffrey Lieberman, Alkomiet Hasan, Oliver Howes, Christoph Correll, Nikolaos Koutsouleris, Paris Alexandros Lalousis   +10 more
wiley   +1 more source

Case report: Time response of plasma clozapine concentrations on cessation of heavy smoking

Frontiers in Pharmacology
Smoking cessation in patients treated with clozapine might lead to elevated plasma concentrations and severe side effects. This case report investigated the trajectory of clozapine plasma concentrations over time after smoking cessation in a Chinese ...
Lingyan Qi, Botao Ma, Hongzhen Fan, Siyuan Qi, Fude Yang, Huimei An   +5 more
doaj   +1 more source

Therapeutic Drug Monitoring of Clozapine and Norclozapine in Human Serum Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry [PDF]

, 2009
D. S. Ming, J.G. Heathcote
openalex   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source