Results 101 to 110 of about 61,552 (282)

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Clozapine N-Oxide Administration Produces Behavioral Effects in Long–Evans Rats: Implications for Designing DREADD Experiments

eNeuro, 2016
Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by Designer Drugs (DREADD) system. This system consists of synthetic G-protein-
D. MacLaren, R. Browne, Jessica K. Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, R. España, S. Clark   +6 more
semanticscholar   +1 more source

Trends in resource utilization for new‐onset psychosis hospitalizations at children's hospitals

Journal of Hospital Medicine, EarlyView.
Abstract Background Children with new‐onset psychosis often require hospitalization for medical evaluation. Objectives The goal of this study was to assess variations in the management of children with new‐onset psychosis and characterize trends in resource utilization.
Ankita Gupta, Matt Hall, Benjamin Masserano, Averi Wilson, Katherine Johnson, Clifford Chen, Lasya Challa, Harita Katragadda, Vineeta Mittal   +8 more
wiley   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications

Macromolecular Materials and Engineering, EarlyView.
Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian, Michael T. Cook, Cécile A. Dreiss   +2 more
wiley   +1 more source

Delayed onset, protracted delirium and aspiration pneumonitis associated with a combination of clozapine and electroconvulsive therapy

Indian Journal of Psychological Medicine, 2011
Few studies reported the efficacy and safety in combination of clozapine and electroconvulsive therapy (ECT) in schizophrenia; systematic studies are lacking. Side effects like seizure, and confusional state are reported.
N Manjunatha, G S Ram Kumar, R Vidyendaran, K Muralidharan, J P John   +4 more
doaj   +1 more source

Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis

Case Reports in Psychiatry, 2021
Clozapine, the choice atypical antipsychotic for refractory schizophrenia, schizoaffective disorder, and bipolar disorder, has been shown to reduce positive and negative symptoms of schizophrenia.
Melissa Sussman, Michael Epifania, Derrick Eng, Yun Jae Cho, Richard Steward   +4 more
doaj   +1 more source

Dynamic Video Assessment of Axial Postural Abnormalities in Parkinson's Disease: A Pilot Study

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Axial postural abnormalities (APAs) are frequent and disabling axial symptoms of Parkinson's disease (PD). Image‐based measurement is considered the gold standard but may not accurately detect the true severity of APAs because these symptoms can appear or get worse under dynamic conditions.
Carlo Alberto Artusi, Christian Geroin, Clarissa Pandino, Serena Camozzi, Stefano Aldegheri, Leonardo Lopiano, Michele Tinazzi, Nicola Bombieri   +7 more
wiley   +1 more source

Prevalence of Parkinson's Disease in 22q11.2 Deletion Syndrome: A Multicenter Study

Movement Disorders Clinical Practice, EarlyView.
Abstract Background 22q11.2 deletion syndrome (22q11.2DS) has been associated with increased risk of early‐onset Parkinson's disease (PD). Objective To determine the prevalence and predictors of PD in a large international 22q11.2DS sample. Methods The sample comprised 856 adults (median age 28 (range 16–76) years; 53.0% female).
Emma N.M.M. von Scheibler, Ann Swillen, Gabriela M. Repetto, Nikolai Gil D. Reyes, Anthony E. Lang, Connie Marras, Mark L. Kuijf, Rob P.W. Rouhl, Agnies M. van Eeghen, Carlos Juri, Annick Vogels, Thérèse A.M.J. van Amelsvoort, Anne S. Bassett, Erik Boot   +13 more
wiley   +1 more source

Barriers to using clozapine in treatment-resistant schizophrenia: systematic review

BJPsych Bulletin, 2018
Aims and method To systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018.
S. Farooq, A. Choudry, D. Cohen, Farooq Naeem, M. Ayub   +4 more
semanticscholar   +1 more source