Results 91 to 100 of about 5,327 (202)

Regulatory interplay of RpoS and RssB controls motility and colonization in Vibrio cholerae

International Journal of Medical Microbiology, 2022
Cholera is a life-threatening diarrheal disease caused by the human pathogenic bacterium Vibrio cholerae. Regulatory elements are essential for bacterial transition between the natural aquatic environment and the human host.
Martina Wölflingseder, Sarah Tutz, Vera H. Fengler, Stefan Schild, Joachim Reidl   +4 more
doaj   +1 more source

Single molecule fluorescence spectroscopy of ClpXP-mediated substrate degradation [PDF]

, 2009
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.Includes bibliographical references (leaves 67-71).Energy-dependent proteases, such as ClpXP, are responsible for the regulated destruction of proteins in ...
Shin, Yongdae
core  

The non-motile phenotype of Salmonella hha ydgT mutants is mediated through PefI-SrgD [PDF]

, 2011
Background Two ancestral nucleoid-associated proteins called Hha and YdgT contribute to the negative regulation of several virulence-associated genes in Salmonella enterica serovar Typhimurium.
Lauren E Wallar, Andrew M Bysice, Brian K Coombes   +2 more
core   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, Volume 600, Issue 1, Page 83-98, January 2026.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease

Scientific Reports, 2018
More than one thousand knotted protein structures have been identified so far, but the functional roles of these knots remain elusive. It has been postulated that backbone entanglement may provide additional mechanostability.
Manoj Kumar Sriramoju, Yen Chen, Yun-Tzai Cloud Lee, Shang-Te Danny Hsu   +3 more
doaj   +1 more source

Caulobacter crescentus CdnL is a non-essential RNA polymerase-binding protein whose depletion impairs normal growth and rRNA transcription. [PDF]

, 2017
CdnL is an essential RNA polymerase (RNAP)-binding activator of rRNA transcription in mycobacteria and myxobacteria but reportedly not in Bacillus. Whether its function and mode of action are conserved in other bacteria thus remains unclear.
Collier, J., Elías-Arnanz, M., Gallego-García, A., González, D., Iniesta, A.A., Padmanabhan, S.   +5 more
core   +1 more source

Lon degrades stable substrates slowly but with enhanced processivity, redefining the attributes of a successful AAA+ protease

Cell Reports, 2023
Summary: Lon is a widely distributed AAA+ (ATPases associated with diverse cellular activities) protease known for degrading poorly folded and damaged proteins and is often classified as a weak protein unfoldase.
Meghann R. Kasal, Hema Chandra Kotamarthi, Madeline M. Johnson, Hannah M. Stephens, Matthew J. Lang, Robert T. Sauer, Tania A. Baker   +6 more
doaj   +1 more source

Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo [PDF]

, 2009
January 1, 2011The essential proteins DnaB, DnaD and DnaI of Bacillus subtilis are required for initiation, but not elongation, of DNA replication, and for replication restart at stalled forks.
Atlung, Baker, Baker, Berkmen, Bowers, Bramhill, Braun, Breier, Brown, Bruand, Bruand, Bruand, Bruck, Burkholder, Chen, Davey, Garner, Goranov, Griffith, Hoshino, Imai, Ioannou, Ishida, Ishigo-Oka, Kaguni, Karamata, Kato, Keyamura, Kornberg, Lemon, Li, Li, Lu, Marsin, Marszalek, McGinness, Messer, Messer, Middleton, Moriya, Mott, Murray, Noirot-Gros, Noirot-Gros, Ogura, Polard, Randell, Rokop, Sakamoto, Sivaprasad, Speck, Speck, Sueoka, Turner, Vagner, Velten, von Freiesleben, Wang, Watabe, Winston, Zhang, Zhang   +61 more
core   +1 more source

Optical Tweezers for Monitoring Unfolding by the Protease ClpXP

Frontiers in Optics 2013, 2013
The biological motor ClpXP pulls against a targeted protein until it mechanically unfolds and translocates the polypeptide into a chamber for degradation. We directly monitor degradation of model polyprotein substrates in dual-trap single molecule assays. Article not available.
Juan Carlos Cordova, Yongdae Shin, Stephane Calmat, Karl R. Schmitz, Marie-Eve Aubin-Tam, Adrian Olivares, Robert T. Sauer, Tania A. Baker, Matthew J. Lang   +8 more
openaire   +2 more sources

Effects of Lipopolysaccharide Core Modulation on Outer Membrane Protein Function and Virulence in Pectobacterium carotovorum

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
The LPS core is critical for virulence in Pectobacterium carotovorum, as its truncation disrupts outer membrane protein assembly, reducing protease secretion, motility, and soft rot symptoms. ABSTRACT Lipopolysaccharide (LPS) is a critical component of the bacterial outer membrane, which serves as a permeability barrier and site for sensing ...
Yejin Park, Jihui Hwang, Jaeyoung Choi, Eunhye Goo, Jae Hoon Lee   +4 more
wiley   +1 more source