Results 111 to 120 of about 5,327 (202)
Microbial Biotechnology, Volume 18, Issue 7, July 2025.Cupriavidus necator is a promising microbe for one‐carbon biomanufacturing. Newly sequenced strains and a comparative assessment of all available genomes define further this species and its traits of interest. ABSTRACT The transition from a petroleum‐based manufacturing to biomanufacturing is an important step towards a sustainable bio‐economy.
Magnus G. Jespersen +4 more
wiley +1 more source
Roles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation and chaperone activity [PDF]
, 2013 Degron binding regulates the activities of the AAA+ Lon protease in addition to targeting proteins for degradation. The sul20 degron from the cell-division inhibitor SulA is shown here to bind to the N domain of Escherichia coli Lon, and the recognition ...
Baker, Tania +2 more
core +1 more source
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, Volume 66, Issue 5, Page 222-242, June 2025.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source
Multiple Sequence Signals Direct Recognition and Degradation of Protein Substrates by the AAA+ Protease HslUV [PDF]
, 2010 Proteolysis is important for protein quality control and for the proper regulation of many intracellular processes in prokaryotes and eukaryotes. Discerning substrates from other cellular proteins is a key aspect of proteolytic function.
Baker, Tania +3 more
core +1 more source
Angewandte Chemie, Volume 137, Issue 18, April 25, 2025.Ein schematischer Überblick über die schädlichen Wirkungen von Ciprofloxacin im Zusammenhang mit mitochondrialer Toxizität. AIFM1 spielt eine Rolle beim MIA40‐vermittelten Import in das IMS und bei der oxidativen Faltung von kernkodierten Proteinen, einschließlich der Untereinheiten der ETC‐Komplexe I und IV.
Till Reinhardt +14 more
wiley +1 more source
NifB and NifEN protein levels are regulated by ClpX2 under nitrogen fixation conditions in Azotobacter vinelandii [PDF]
, 2011 The major part of biological nitrogen fixation is catalysed by the molybdenum nitrogenase that carries at its active site the iron and molybdenum cofactor (FeMo-co).
Curatti, Leonardo +3 more
core +1 more source
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. [PDF]
, 2020 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Myasnikov, Alexander +3 more
core +3 more sources
Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease [PDF]
Journal of Bacteriology, 1996 In Escherichia coli, starvation (stationary-phase)-mediated differentiation involves 50 or more genes and is triggered by an increase in cellular sigma s levels. Western immunoblot analysis showed that in mutants lacking the protease ClpP or its cognate ATPase-containing subunit ClpX, sigma s levels of exponential-phase cells increased to those of ...
T, Schweder +3 more
openaire +2 more sources
Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity
Angewandte Chemie International Edition, Volume 64, Issue 18, April 25, 2025.A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt +14 more
wiley +1 more source
A connecter-like factor, CacA, links RssB/RpoS and the CpxR/CpxA two-component system in Salmonella [PDF]
, 2012 BACKGROUND: Bacteria integrate numerous environmental stimuli when generating cellular responses. Increasing numbers of examples describe how one two-component system (TCS) responds to signals detected by the sensor of another TCS. However, the molecular
Akinori Kato +5 more
core +1 more source